{"id":35578,"date":"2026-08-28T05:48:00","date_gmt":"2026-08-28T05:48:00","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=35578"},"modified":"2026-08-28T07:50:31","modified_gmt":"2026-08-28T07:50:31","slug":"eunun-multipl-myelom-tedavisine-yonelik-projesine-tubitak-destegi","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2026\/08\/28\/eunun-multipl-myelom-tedavisine-yonelik-projesine-tubitak-destegi\/","title":{"rendered":"E\u00dc\u2019n\u00fcn multipl myelom tedavisine y\u00f6nelik projesine T\u00dcB\u0130TAK deste\u011fi"},"content":{"rendered":"

E\u00dc T\u0131p Fak\u00fcltesi \u00f6\u011fretim \u00fcyesi Prof. Dr. Bur\u00e7in Kaymaz y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcnde haz\u0131rlanan ve multipl miyelom hastal\u0131\u011f\u0131nda tedavi direncini k\u0131rmay\u0131 hedefleyen yenilik\u00e7i proje, T\u00dcB\u0130TAK 1001 Program\u0131 kapsam\u0131nda desteklenmeye hak kazand\u0131.<\/p>\n

\u0130ZM\u0130R(Ege Ajans)-\u00a0<\/b>Ege \u00dcniversitesi (E\u00dc) T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Bur\u00e7in Kaymaz\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cCD138 H\u00fccre Fraksiyonlar\u0131n\u0131n Transkriptomik \u0130mzas\u0131: \u00dc\u00e7l\u00fc S\u0131n\u0131f Refrakter Multipl Miyelomda Diren\u00e7 Mekanizmalar\u0131n\u0131n Ayd\u0131nlat\u0131lmas\u0131 ve Translasyonel Bir Strateji\u201d ba\u015fl\u0131kl\u0131 proje,\u00a0 T\u00dcB\u0130TAK 1001 Program\u0131 kapsam\u0131nda desteklenmeye uygun bulundu. Proje, bir kemik ili\u011fi kanseri t\u00fcr\u00fc olan multipl miyelom\u2019un tedavisine y\u00f6nelik yeni bir \u00e7\u00f6z\u00fcm sunmay\u0131 hedefliyor.<\/p>\n

Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Musa Alc\u0131, Prof. Dr. Kaymaz ve ekibini tebrik ederek ba\u015far\u0131lar\u0131n\u0131n devam\u0131n\u0131 diledi.<\/p>\n

Proje hakk\u0131nda bilgi veren Prof. Dr. Bur\u00e7in Kaymaz, \u201cProje kapsam\u0131nda, \u00fc\u00e7l\u00fc s\u0131n\u0131f refrakter multipl miyelomda CD138\u207a\/CD138\u207b h\u00fccrelerinin transkriptomik analiziyle diren\u00e7 imzas\u0131 tan\u0131mlanacak ve ila\u00e7 yeniden konumland\u0131rmas\u0131yla aday tedavi stratejisi geli\u015ftirilecek. \u00dc\u00e7l\u00fc s\u0131n\u0131f refrakter multipl miyelomda mevcut tedavilere diren\u00e7 geli\u015fmesi nedeniyle etkili tedavi se\u00e7enekleri yetersiz ve hastalar\u0131n sa\u011fkal\u0131m\u0131 s\u0131n\u0131rl\u0131d\u0131r. Projemiz; CD138\u207a ve CD138\u207b h\u00fccre fraksiyonlar\u0131n\u0131n transkriptomik analizini kullanarak diren\u00e7 mekanizmalar\u0131n\u0131 ortaya \u00e7\u0131karmay\u0131, diren\u00e7le ili\u015fkili molek\u00fcler imzay\u0131 tan\u0131mlamay\u0131 ve ila\u00e7 yeniden konumland\u0131rmas\u0131 yakla\u015f\u0131m\u0131yla do\u011frulanabilir yeni bir aday tedavi stratejisi geli\u015ftirerek bu \u00f6nemli klinik gereksinime \u00e7\u00f6z\u00fcm sunmay\u0131 ama\u00e7l\u0131yor\u201d dedi.<\/p>\n

Bilgisayar destekli analizlerle hedefe y\u00f6nelik ila\u00e7lar belirlenecek<\/b><\/p>\n

Prof. Dr. Kaymaz, \u201cProjede, \u00fc\u00e7l\u00fc s\u0131n\u0131f refrakter multipl miyelom hastalar\u0131ndan al\u0131nan kemik ili\u011fi \u00f6rneklerindeki CD138\u207a ve CD138\u207b h\u00fccreler ayr\u0131larak genlerin \u00e7al\u0131\u015fma profilleri (RNA dizileme) incelenecek. Elde edilen veriler, mevcut uluslararas\u0131 veri tabanlar\u0131yla birlikte analiz edilerek hastal\u0131\u011f\u0131n tedaviye diren\u00e7le ili\u015fkili gen imzas\u0131 belirlenecek. Daha sonra bilgisayar destekli analizlerle bu diren\u00e7 imzas\u0131n\u0131 tersine \u00e7evirebilecek aday ila\u00e7lar se\u00e7ilecek. Se\u00e7ilen ila\u00e7lar \u00f6nce multipl miyelom h\u00fccrelerinde, ard\u0131ndan hasta h\u00fccrelerinde test edilerek etkileri ve diren\u00e7 mekanizmalar\u0131n\u0131 hedefleme ba\u015far\u0131lar\u0131 do\u011frulanacak.\u00a0Proje sonunda 14 hastadan elde edilen h\u00fccre fraksiyonlar\u0131n\u0131n RNA dizileme verilerinin analiziyle 8\u201312 genlik diren\u00e7 imzas\u0131 olu\u015fturulacak, ila\u00e7 yeniden konumland\u0131rmas\u0131yla aday ila\u00e7 belirlenecek ve bu aday hem multipl miyelom h\u00fccre hatlar\u0131nda hem de hasta kaynakl\u0131 h\u00fccrelerde do\u011frulanacak\u201d diye konu\u015ftu.<\/p>\n

Projenin ki\u015fiselle\u015ftirilmi\u015f tedavi yakla\u015f\u0131mlar\u0131n\u0131n geli\u015ftirilmesine katk\u0131 sa\u011flayaca\u011f\u0131n\u0131 belirten Prof. Dr. Kaymaz, geli\u015ftirilecek diren\u00e7 gen panelinin tedavi yan\u0131t\u0131n\u0131n \u00f6ng\u00f6r\u00fclmesine y\u00f6nelik gelecekteki tan\u0131sal uygulamalara temel olu\u015fturaca\u011f\u0131n\u0131 ve ya\u015fam s\u00fcresi ile ya\u015fam kalitesini art\u0131raca\u011f\u0131n\u0131 s\u00f6yledi.<\/p>\n

Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Prof. Dr. Bur\u00e7in Kaymaz\u2019\u0131n yapt\u0131\u011f\u0131 proje ekibinde; Do\u00e7. Dr. Derya Demir, Prof. Dr. Fahri \u015eahin, Prof. Dr. G\u00fcray Saydam, Prof. Dr. Nur Soyer, Dr. \u00d6\u011fr. \u00dcyesi Ajda G\u00fcne\u015f, Dr. \u00d6\u011fr. \u00dcyesi Nurcan G\u00fcm\u00fc\u015f, Dr. \u00d6\u011fr. \u00dcyesi Ya\u011fmur Kiraz Durmaz ve Dr. Selattin Alperen Uysal yer al\u0131yor. Proje; Ege \u00dcniversitesinin yan\u0131 s\u0131ra \u0130zmir Bak\u0131r\u00e7ay ve Ekonomi \u00dcniversiteleri ortakl\u0131\u011f\u0131nda y\u00fcr\u00fct\u00fcl\u00fcyor.<\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

E\u00dc T\u0131p Fak\u00fcltesi \u00f6\u011fretim \u00fcyesi Prof. Dr. Bur\u00e7in Kaymaz y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcnde haz\u0131rlanan ve multipl miyelom hastal\u0131\u011f\u0131nda tedavi direncini k\u0131rmay\u0131 hedefleyen yenilik\u00e7i proje, T\u00dcB\u0130TAK 1001 Program\u0131 kapsam\u0131nda desteklenmeye hak kazand\u0131. \u0130ZM\u0130R(Ege Ajans)-\u00a0Ege…<\/p>\n","protected":false},"author":2,"featured_media":35580,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70],"tags":[],"class_list":["post-35578","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus"],"_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/35578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=35578"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/35578\/revisions"}],"predecessor-version":[{"id":35581,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/35578\/revisions\/35581"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/35580"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=35578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=35578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=35578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}