Ege \u00dcniversitesi N\u00fckleer Bilimler Enstit\u00fcs\u00fc N\u00fckleer Uygulamalar Anabilim Dal\u0131 Ba\u015fkan\u0131 Prof. Dr. Fazilet Z\u00fcmr\u00fct Biber M\u00fcft\u00fcler\u2019in y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131\u00a0\u201cHER2-Pozitif Meme Kanserine Teran\u00f6stik Yakla\u015f\u0131mlar: \u00b9\u2075\u2075\/\u00b9\u2076\u00b9Tb-DOTA-Antikor \u00c7ifti ve Preklinik De\u011ferlendirmeler\u201d\u00a0ba\u015fl\u0131kl\u0131 proje, T\u00dcB\u0130TAK 1001 Program\u0131 kapsam\u0131nda desteklenmeye hak kazand\u0131. Proje ile HER2 pozitif meme kanserinde hedefe y\u00f6nelik tan\u0131 ve tedavi stratejilerinin geli\u015ftirilmesini ama\u00e7l\u0131yor. Proje, Amerika Birle\u015fik Devletleri Alabama \u00dcniversitesi T\u0131p Fak\u00fcltesi Radyoloji B\u00f6l\u00fcm\u00fcnden\u00a0Prof. Dr. Suzanne Lapi\u2019nin\u00a0de yer ald\u0131\u011f\u0131 uluslararas\u0131 bir i\u015f birli\u011fi ile Ege B\u00f6lgesi\u2019ndeki \u00e7e\u015fitli \u00fcniversitelerden akademisyenlerin katk\u0131lar\u0131yla y\u00fcr\u00fct\u00fclecek.<\/p>\n
Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Musa Alc\u0131, projesi T\u00dcB\u0130TAK 1001 Program\u0131 kapsam\u0131nda desteklenmeye uygun g\u00f6r\u00fclen\u00a0Prof. Dr. Z\u00fcmr\u00fct M\u00fcft\u00fcler ve ekibini tebrik ederek ba\u015far\u0131lar\u0131n\u0131n devam\u0131n\u0131 diledi.<\/p>\n
Projenin ama\u00e7lar\u0131na ili\u015fkin de\u011ferlendirmelerde bulunan proje y\u00fcr\u00fct\u00fcc\u00fcs\u00fc\u00a0Prof. Dr. Z\u00fcmr\u00fct M\u00fcft\u00fcler,\u00a0meme kanserinin kad\u0131nlar aras\u0131nda en s\u0131k g\u00f6r\u00fclen kanser t\u00fcrlerinden biri oldu\u011funu ve\u00a0HER2 resept\u00f6r\u00fcn\u00fcn a\u015f\u0131r\u0131 ekspresyonunun,\u00a0t\u00fcm\u00f6rlerin daha agresif bir biyolojik davran\u0131\u015f sergilemesine yol a\u00e7t\u0131\u011f\u0131n\u0131 vurgulad\u0131. Prof. Dr. M\u00fcft\u00fcler, HER2\u2019yi hedefleyen monoklonal antikor temelli yakla\u015f\u0131mlar\u0131n klinik uygulamalarda y\u00fcksek \u00f6zg\u00fcll\u00fck sa\u011flad\u0131\u011f\u0131n\u0131, ancak bireysel tedavi yan\u0131tlar\u0131ndaki farkl\u0131l\u0131klar ve sistemik yan etkilerin halen \u00f6nemli bir sorun te\u015fkil etti\u011fini ifade etti.<\/p>\n
\u201cSa\u011fl\u0131kl\u0131 dokular radyasyondan korunacak\u201d<\/p>\n
Prof. Dr. M\u00fcft\u00fcler, \u201cBu proje kapsam\u0131nda,\u00a0HER2 hedefli bir monoklonal antikor,\u00a0teranostik \u00f6zelliklere sahip\u00a0Terbiyum-155 ve Terbiyum-161\u00a0radyon\u00fcklidleri ile i\u015faretlenerek hem tan\u0131 hem de tedavi amac\u0131yla kullan\u0131labilecek yenilik\u00e7i radyofarmas\u00f6tiklerin geli\u015ftirilmesi hedefleniyor. Teranostik \u00e7ift yakla\u015f\u0131m\u0131 sayesinde, t\u00fcm\u00f6r dokusuna \u00f6zg\u00fc g\u00f6r\u00fcnt\u00fcleme yap\u0131lmas\u0131, tedavi etkinli\u011finin optimize edilmesi ve sa\u011fl\u0131kl\u0131 dokular\u0131n radyasyon maruziyetinin azalt\u0131lmas\u0131 ama\u00e7lan\u0131yor. Proje s\u00fcresince ger\u00e7ekle\u015ftirilecek radyoi\u015faretleme ve kalite kontrol \u00e7al\u0131\u015fmalar\u0131n\u0131n ard\u0131ndan, geli\u015ftirilen Terbiyum radyoizotoplar\u0131 ile i\u015faretli bile\u015fiklerin biyolojik etkinli\u011fi HER2 pozitif ve negatif meme kanseri h\u00fccre hatlar\u0131 \u00fczerinde\u00a0in vitro\u00a0olarak de\u011ferlendirilecek.\u00a0In vivo\u00a0\u00e7al\u0131\u015fmalarda ise deneysel t\u00fcm\u00f6r modelleri kullan\u0131larak sintigrafik g\u00f6r\u00fcnt\u00fcleme, biyoda\u011f\u0131l\u0131m, internal dozimetri ve tedavi etkinli\u011fi analizleri ger\u00e7ekle\u015ftirilecek. Tedavi sonras\u0131 t\u00fcm\u00f6r yan\u0131tlar\u0131, hem g\u00f6r\u00fcnt\u00fcleme y\u00f6ntemleri hem de histopatolojik de\u011ferlendirmelerle incelenecek\u201d dedi.<\/p>\n
Prof. Dr. M\u00fcft\u00fcler, projenin HER2 hedefli teranostik radyofarmas\u00f6tiklerin geli\u015ftirilmesine y\u00f6nelik literat\u00fcrde \u00f6nemli bir bo\u015flu\u011fu dolduraca\u011f\u0131n\u0131 belirterek, \u201cBu proje, meme kanseri tedavisinde daha g\u00fcvenli, etkin ve ki\u015fiselle\u015ftirilmi\u015f yakla\u015f\u0131mlar\u0131n geli\u015ftirilmesine katk\u0131 sa\u011flayacakt\u0131r. Elde edilecek sonu\u00e7lar\u0131n hem ulusal hem de uluslararas\u0131 bilimsel literat\u00fcre ve \u00fclkemizin n\u00fckleer t\u0131p ve radyofarmas\u00f6tik alan\u0131ndaki bilimsel birikimine \u00f6nemli katk\u0131lar sunaca\u011f\u0131na inan\u0131yoruz\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi N\u00fckleer Bilimler Enstit\u00fcs\u00fc N\u00fckleer Uygulamalar Anabilim Dal\u0131 Ba\u015fkan\u0131 Prof. Dr. Fazilet Z\u00fcmr\u00fct Biber…<\/p>\n","protected":false},"author":2,"featured_media":31826,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,11,70],"tags":[],"class_list":["post-31825","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-haber","category-kampus"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",2479,2634,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",141,150,false],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",282,300,false],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",640,680,false],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",640,680,false],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",1446,1536,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",1927,2048,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",678,720,false],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",1024,1088,false],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2026\/01\/Prof.-Dr.-Fazilet-Zumrut-Biber-Muftuler-1.jpeg",358,380,false]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Haber<\/a> Kamp\u00fcs<\/a>","tag_info":"Kamp\u00fcs","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/31825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=31825"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/31825\/revisions"}],"predecessor-version":[{"id":31827,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/31825\/revisions\/31827"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/31826"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=31825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=31825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=31825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}