Ege \u00dcniversitesi M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cKuantum Nokta Tabanl\u0131 Biyoaray\u00fczler ile N\u00f6roinflamasyonun \u0130nd\u00fcklendi\u011fi Serebral Organoidlerin Fotobiyomod\u00fclasyonu\u201d ba\u015fl\u0131kl\u0131 proje, T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) nezdinde kabul edildi. Proje ile n\u00f6roinflamasyonun tedavisinin yeni s\u0131ra, tan\u0131s\u0131nda ve \u015fiddetinin \u00f6l\u00e7\u00fclmesinde kullan\u0131lacak algoritma geli\u015ftirilecek.<\/p>\n
Proje ekibini tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201cSa\u011fl\u0131k temal\u0131 ara\u015ft\u0131rma \u00fcniversitemiz, bu alana y\u00f6nelik \u00f6nemli projeleri literat\u00fcre kazand\u0131rmaya devam ediyor. Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyemiz Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcnde multidisipliner bilim ekibvi taraf\u0131ndan haz\u0131rlanan proje, T\u00dcSEB taraf\u0131ndan desteklenmeye uygun bulundu. Hocam\u0131z\u0131 ve proje ekibini tebrik ediyor, ba\u015far\u0131lar\u0131n\u0131n devam\u0131n\u0131 diliyorum\u201d dedi.<\/p>\n
Projenin amac\u0131n\u0131 anlatan Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f,\u00a0\u201cProjemizdeki ama\u00e7; d\u00fcnyada \u00e7\u0131\u011f\u0131r a\u00e7an ve g\u00fcn\u00fcm\u00fczde bir\u00e7ok ara\u015ft\u0131rman\u0131n ilgi oda\u011f\u0131nda yer alan biyoteknolojik ara\u00e7lardan biri olarak, zengin n\u00f6ronal ve glial h\u00fccre tiplerine sahip ve ger\u00e7ek insan beynini laboratuvar ko\u015fullar\u0131nda taklit edebilen yapay beyin organoidleri ile olu\u015fturaca\u011f\u0131m\u0131z n\u00f6roinflamasyon modelinde, kuantum nokta tabanl\u0131 biyoaray\u00fczler ile \u00e7al\u0131\u015faca\u011f\u0131m\u0131z fotobiyomod\u00fclasyon y\u00f6nteminin terap\u00f6tik etkisini incelemektir. Ayr\u0131ca, bu uygulama ile elde edilecek veriler ile n\u00f6roinflamasyonun varl\u0131\u011f\u0131n\u0131, \u015fiddetini ve terap\u00f6tik yan\u0131t\u0131n\u0131 tahmin etmek i\u00e7in y\u00fcksek do\u011frulukta kullan\u0131labilecek yapay zek\u00e2 temelli derin \u00f6\u011frenme algoritmalar\u0131n\u0131n geli\u015ftirilmesi hedeflenmektedir\u201d dedi.<\/p>\n
\u201cYenilik\u00e7i yakla\u015f\u0131mlar \u00fclkemiz ve d\u00fcnya i\u00e7in \u00f6nem ta\u015f\u0131yor\u201d<\/b><\/p>\n
N\u00f6roinflamasyonun tan\u0131m\u0131n\u0131 yapan Prof. Dr. Ye\u015fil \u00c7elikta\u015f, \u201cN\u00f6roinflamasyon, merkezi sinir sistemindeki imm\u00fcn yan\u0131t\u0131n \u015fiddetlenmesi ve kronik bir hale gelmesiyle karakterize edilen bir durumdur. Alzheimer, Parkinson ve multiple skleroz gibi n\u00f6rodejeneratif hastal\u0131klarda temel bir patofizyolojik unsur olarak \u00f6ne \u00e7\u0131kmakta ve hastal\u0131\u011f\u0131n progresyonunu h\u0131zland\u0131ran bir fakt\u00f6r olarak rol oynamaktad\u0131r. Bu nedenle, n\u00f6roinflamasyonu hedef alan yenilik\u00e7i terap\u00f6tik yakla\u015f\u0131mlar hem \u00fclkemiz hem de t\u00fcm d\u00fcnya i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r. Son d\u00f6nemde y\u00fcr\u00fct\u00fclen translasyonel \u00e7al\u0131\u015fmalarda, \u00f6zg\u00fcn optoelektronik \u00f6zelliklere sahip yar\u0131 iletken kuantum noktalar ve belirli dalga boylar\u0131ndaki \u0131\u015f\u0131\u011f\u0131n biyolojik dokular \u00fczerinde terap\u00f6tik etkiler yaratmas\u0131n\u0131 i\u00e7eren fotobiyomod\u00fclasyon ad\u0131 verilen tedavi y\u00f6nteminin geli\u015ftirilmesi olduk\u00e7a \u00f6zg\u00fcnd\u00fcr. Bu sebeple s\u00f6z konusu projemizde, fotobiyomod\u00fclasyon ile inflamatuar sinyaller aras\u0131ndaki molek\u00fcler etkile\u015fimleri incelemek, n\u00f6ronal hastal\u0131klar\u0131n patogenezini anlamak ve klini\u011fe y\u00f6nelik tedavilerin geli\u015ftirilmesi i\u00e7in b\u00fcy\u00fck \u00f6nem arz etmektedir\u201d diye konu\u015ftu.<\/p>\n
\u201c12. Kalk\u0131nma Plan\u0131 hedeflerine uygun proje\u201d<\/b><\/p>\n
Prof. Dr. Ye\u015fil \u00c7elikta\u015f, \u201cProjemiz, \u00fclkemizin 12. Kalk\u0131nma Planlar\u0131nda yer alan hedefler kapsam\u0131ndaki \u00f6ncelikli \u00e7al\u0131\u015fma alanlar\u0131nda ilerleyen multidisipliner translasyonel ara\u015ft\u0131rma niteli\u011findedir. Bu proje ile \u00fclkemizde translasyonel n\u00f6robilim alan\u0131nda, d\u00fcnya standartlar\u0131nda \u00e7al\u0131\u015fmalar y\u00fcr\u00fct\u00fclecek olup, \u00fclkemizin kalk\u0131nmas\u0131 ve yeni nesil ara\u015ft\u0131rmac\u0131lar\u0131n yeti\u015ftirilmesi konusunda katk\u0131 sa\u011flanacakt\u0131r\u201d dedi.<\/p>\n
Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f\u00a0y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 multidisipliner projede; Ege \u00dcniversitesi Solunum Ara\u015ft\u0131rmalar\u0131 Merkezinden Dr. Pelin Sa\u011flam Metiner, Ko\u00e7 \u00dcniversitesi Elektrik Elektronik M\u00fchendisli\u011fi B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Prof. Dr. Sedat Nizamo\u011flu, Dokuz Eyl\u00fcl \u00dcniversitesi \u0130zmir Uluslararas\u0131 Biyot\u0131p ve Genom Enstit\u00fcs\u00fcnden ara\u015ft\u0131rmac\u0131 Do\u00e7. Dr. Serhat Tozburun ve Dr. \u00d6\u011fr. \u00dcyesi Merve T\u00fcrker Burhan yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131…<\/p>\n","protected":false},"author":2,"featured_media":30180,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1],"tags":[],"class_list":["post-30179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Doc.Dr_.Ozlem-Yesil-Celiktas-Prof.-Dr.-Necdet-Budak-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a>","tag_info":"G\u00fcncel","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/30179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=30179"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/30179\/revisions"}],"predecessor-version":[{"id":30181,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/30179\/revisions\/30181"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/30180"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=30179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=30179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=30179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}