Egeli bilim insan\u0131 Do\u00e7. Dr. Ekinci\u2019den eklemlerdeki sinovyal zar\u0131n iltihaplanmas\u0131n\u0131n te\u015fhisine y\u00f6nelik proje<\/p>\n
Ege \u00dcniversitesi Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Eczac\u0131l\u0131k Teknolojisi B\u00f6l\u00fcm\u00fc Radyofarmasi Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Meliha Ekinci\u2019nin y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cRadyoi\u015faretli anti-TNF-\u03b1 monoklonal antikor i\u00e7eren nanopartik\u00fcler form\u00fclasyonlar\u0131n romatoid artrit tan\u0131s\u0131 amac\u0131yla g\u00f6r\u00fcnt\u00fcleme potansiyelinin in vivo \u00e7al\u0131\u015fmalar ile de\u011ferlendirilmesi\u201d ba\u015fl\u0131kl\u0131 proje T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) 2025 Y\u0131l\u0131 B Grubu Ar-Ge Proje \u00c7a\u011fr\u0131s\u0131 kapsam\u0131nda desteklenmeye uygun bulundu.<\/p>\n
Proje Y\u00fcr\u00fct\u00fcc\u00fcs\u00fc Do\u00e7. Dr. Meliha Ekinci\u2019yi makam\u0131nda a\u011f\u0131rlayan Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, sa\u011fl\u0131k temal\u0131 yenilik\u00e7i Ar-Ge projesi \u00e7al\u0131\u015fmas\u0131ndan dolay\u0131 tebrik ederek ba\u015far\u0131lar diledi. Rekt\u00f6r Prof. Dr. Budak, \u201cTam akredite, \u00f6\u011frenci odakl\u0131, sa\u011fl\u0131k temal\u0131 ara\u015ft\u0131rma \u00fcniversitemiz bilim insanlar\u0131 sa\u011fl\u0131k bilimleri ve teknolojileri temal\u0131, yenilik\u00e7i, ihtiya\u00e7 odakl\u0131 ve \u00fcr\u00fcn geli\u015ftirmeye y\u00f6nelik stratejik ara\u015ft\u0131rma geli\u015ftirme projeleri \u00fcretmeye devam ediyor. \u00dclkemizin uluslararas\u0131 kalite standartlar\u0131nda, referans g\u00f6sterilen\u00a0 ara\u015ft\u0131rma \u00fcniversitesi ekosisteminde\u00a0 katma de\u011fer yaratabilecek nitelikte, Ar-Ge ve inovasyon \u00e7al\u0131\u015fmalar\u0131 y\u00fcr\u00fcten Do\u00e7. Dr. Meliha Ekinci hocam\u0131z\u0131 y\u00fcrekten kutluyorum\u201d dedi.<\/p>\n
Y\u00fcr\u00fct\u00fclen ara\u015ft\u0131rma ile ilgili bilgi veren Do\u00e7. Dr. Meliha Ekinci,\u00a0 \u201cRomatoid artrit (RA), a\u011fr\u0131ya neden olan ve erken ve yo\u011fun bir \u015fekilde tedavi edilmezse ilerleyici eklem y\u0131k\u0131m\u0131 ve g\u00fc\u00e7s\u00fczl\u00fc\u011fe yol a\u00e7an kronik inflamatuar sinovyal tutulumla karakterize sistemik bir hastal\u0131kt\u0131r. Sinovitin erken te\u015fhisi, komplikasyonlar\u0131 \u00f6nlemek veya geciktirmek i\u00e7in olduk\u00e7a \u00f6nemlidir. RA tan\u0131s\u0131, risk fakt\u00f6rleri, artritli eklem say\u0131s\u0131, antisitr\u00fclin protein antikorlar\u0131 d\u00fczeyleri, eritrosit sedimantasyon h\u0131z\u0131, C-reaktif protein ve a\u011fr\u0131, \u015fi\u015flik ve hassasiyet gibi semptomlar\u0131 i\u00e7eren hasta puan\u0131n\u0131n de\u011ferlendirilmesiyle yap\u0131labilir. Ayr\u0131ca, Amerikan Romatoloji Koleji ve Avrupa Romatizma Birli\u011fi, daha do\u011fru bir tan\u0131 elde etmek i\u00e7in eklemlerin ve \u00e7evreleyen dokular\u0131n radyolojik veya n\u00fckleer t\u0131p teknikleriyle g\u00f6r\u00fcnt\u00fclenmesini \u00f6nermektedir. N\u00fckleer t\u0131p teknikleri, inflamatuar artropatilerden etkilenen hastalarda aktivite durumunu de\u011ferlendirmek i\u00e7in y\u0131llard\u0131r uygulanmaktad\u0131r. Son y\u0131llarda, spesifik radyofarmas\u00f6tiklerin geli\u015ftirilmesi, bu tekniklerin yaln\u0131zca hastalar\u0131n de\u011ferlendirilmesinde ve izlenmesinde de\u011fil, ayn\u0131 zamanda hastal\u0131k mekanizmalar\u0131n\u0131 a\u00e7\u0131klamak i\u00e7in de kullan\u0131lma olas\u0131l\u0131\u011f\u0131 ve hekime tedavi ve takip konusunda yard\u0131mc\u0131 olabilmesi a\u00e7\u0131s\u0131ndan \u00f6nemlidir.\u201d diye konu\u015ftu.<\/p>\n
Spesifik anti-TNF-\u03b1 terap\u00f6tiklerinin geli\u015ftirilmesi, RA’n\u0131n klinik tedavisinde olduk\u00e7a \u00f6nemli oldu\u011funu vurgulayan \u00a0Do\u00e7. Dr. Meliha Ekinci,\u00a0 \u201cT\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc \u03b1 (TNF-\u03b1), RA’n\u0131n kronik inflamatuar ve y\u0131k\u0131c\u0131 s\u00fcrecinde merkezi bir role sahiptir. Bir dizi \u00e7al\u0131\u015fma, bu sitokini romatoid eklemde tespit etmi\u015f ve TNF-\u03b1’n\u0131n sinoviti art\u0131rma ve s\u00fcrd\u00fcrme yetene\u011fini g\u00f6stermi\u015ftir. B\u00f6ylelikle, spesifik anti-TNF-\u03b1 terap\u00f6tiklerinin geli\u015ftirilmesi, RA’n\u0131n klinik tedavisinde olduk\u00e7a \u00f6nemli hale gelmi\u015ftir. \u015eu anda, TNF-\u03b1 inhibit\u00f6r ila\u00e7lar\u0131 ya \u00e7\u00f6z\u00fcn\u00fcr resept\u00f6rler (etanersept) ya da monoklonal antikorlar (infliximab, adalimumab ve golimumab) \u015feklinde bulunmaktad\u0131r. Klinikte, [99mTc]Tc ile i\u015faretlenmi\u015f spesifik olmayan imm\u00fcnoglobulin G (IgG) uzun zamand\u0131r iltihab\u0131 g\u00f6r\u00fcnt\u00fclemek i\u00e7in kullan\u0131lmaktad\u0131r. IgG’nin inflamatuar odaklara lokalizasyonu esas olarak artan vask\u00fcler ge\u00e7irgenlik gibi spesifik olmayan mekanizmalardan kaynaklanmaktad\u0131r. Bu nedenle IgG ve di\u011fer radyofarmas\u00f6tik ajanlar\u0131n se\u00e7icili\u011fi, bunlar\u0131 spesifik molek\u00fcllerle hedefleyerek art\u0131r\u0131labilir. Adalimumab, y\u00fcksek afinite ve \u00f6zg\u00fcll\u00fc\u011fe sahip tamamen insan monoklonal anti-TNF-\u03b1 antikorudur. Ayn\u0131 zamanda Golimumab, RA ve \u00fclseratif kolit tedavisinde kullan\u0131lan anti-TNF-\u03b1 bir insan monoklonal antikorudur. Bu monoklonal antikorlar\u0131n terap\u00f6tik kullan\u0131m\u0131, hastalar\u0131n \u00e7o\u011funda h\u0131zl\u0131 klinik iyile\u015fme sa\u011flamakta olup eklem y\u0131k\u0131m\u0131n\u0131 \u00f6nleme veya geciktirme yetene\u011fine sahiptir\u201d dedi.<\/p>\n
Do\u00e7. Dr. Meliha Ekinci, \u201cN\u00fckleer t\u0131pta radyofarmas\u00f6tikler kullan\u0131larak, hedef dokularda meydana gelen fizyolojik de\u011fi\u015fiklikler erken evrede saptanabildi\u011finden bu alanda yeni radyofarmas\u00f6tiklerin geli\u015ftirilmesi olduk\u00e7a \u00f6nemlidir. Bu nedenle bu projenin amac\u0131, RA\u2019n\u0131n erken evre tan\u0131s\u0131nda kullan\u0131lmak \u00fczere [99mTc]Tc ile i\u015faretli, adalimumab ve golimumab i\u00e7eren, nanopartik\u00fcler yap\u0131da iki yeni yerli ve milli nanobiyoradyofarmas\u00f6tik geli\u015ftirmektir. Geli\u015ftirilen radyofarmas\u00f6tiklerin etkinli\u011fi ger\u00e7ekle\u015ftirilecek olan h\u00fccre k\u00fclt\u00fcr\u00fc ve in vivo biyoda\u011f\u0131l\u0131m ve g\u00f6r\u00fcnt\u00fcleme \u00e7al\u0131\u015fmalar\u0131 ile belirlenecektir\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"
Egeli bilim insan\u0131 Do\u00e7. Dr. Ekinci\u2019den eklemlerdeki sinovyal zar\u0131n iltihaplanmas\u0131n\u0131n te\u015fhisine y\u00f6nelik proje Ege \u00dcniversitesi…<\/p>\n","protected":false},"author":2,"featured_media":30100,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,11],"tags":[],"class_list":["post-30099","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-haber"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/09\/Prof.-Dr.-Necdet-Budak-Doc.-Dr.-Meliha-Ekinci-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Haber<\/a>","tag_info":"Haber","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/30099","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=30099"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/30099\/revisions"}],"predecessor-version":[{"id":30101,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/30099\/revisions\/30101"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/30100"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=30099"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=30099"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=30099"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}