{"id":28597,"date":"2025-06-16T05:26:00","date_gmt":"2025-06-16T05:26:00","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=28597"},"modified":"2025-06-16T07:27:20","modified_gmt":"2025-06-16T07:27:20","slug":"egeli-bilim-insani-doc-dr-burcin-kaymazdan-yenilikci-ve-ozgun-bir-proje-daha","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2025\/06\/16\/egeli-bilim-insani-doc-dr-burcin-kaymazdan-yenilikci-ve-ozgun-bir-proje-daha\/","title":{"rendered":"Egeli bilim insan\u0131 Do\u00e7. Dr. Bur\u00e7in Kaymaz\u2019dan yenilik\u00e7i ve \u00f6zg\u00fcn bir proje daha\u2026"},"content":{"rendered":"

\u00a0Ege \u00dcniversitesinin sa\u011fl\u0131k temal\u0131 projeleri T\u00dcB\u0130TAK\u2019tan destek almaya devam ediyor<\/strong><\/p>\n

Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Bur\u00e7in Kaymaz\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201c\u00c7inko Tabanl\u0131 Metal Organik \u00c7er\u00e7eve Ta\u015f\u0131ma Sistemi ile Yeni Sentetik Kannabinoidlerin L\u00f6semide \u0130matinib Direncinin K\u0131r\u0131lmas\u0131 \u00dczerine Etkilerinin Proteomiks ve RNA Dizileme B\u00fct\u00fcnle\u015fik Biyoinformatik Arac\u0131l\u0131 Bir Yakla\u015f\u0131mla Terap\u00f6tik Etkinli\u011finin Ara\u015ft\u0131r\u0131lmas\u0131\u201d ba\u015fl\u0131kl\u0131 proje T\u00dcB\u0130TAK 1001 Ar-Ge Proje \u00c7a\u011fr\u0131lar\u0131 kapsam\u0131nda desteklenmeye uygun bulundu. Proje ile kronik myeloid l\u00f6semi hastal\u0131\u011f\u0131n\u0131n tedavisinde kullan\u0131lan \u0130matinib\u2019e kar\u015f\u0131 geli\u015ftirilen ila\u00e7 direnci sebebiyle, sentetik kannabinoidlerin KML \u00fczerindeki terap\u00f6tik etkinli\u011fi ve biyouyumlu ila\u00e7 sistemleri olan metal organik kafesler kullan\u0131larak bu etkinli\u011fin art\u0131r\u0131lmas\u0131 biyoinformatik ile b\u00fct\u00fcnleyici bir yakla\u015f\u0131mla ara\u015ft\u0131r\u0131lacak.<\/p>\n

Do\u00e7. Dr. Bur\u00e7in Kaymaz\u2019\u0131 makam\u0131nda a\u011f\u0131rlayan Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, kendisini \u00e7al\u0131\u015fmalar\u0131ndan dolay\u0131 tebrik ederek ba\u015far\u0131lar diledi. Rekt\u00f6r Prof. Dr. Budak, \u201cEge \u00dcniversitesi \u00fclkemizin g\u00fc\u00e7l\u00fc sa\u011fl\u0131k altyap\u0131s\u0131na sahip y\u00fcksek\u00f6\u011fretim kurumlar\u0131 aras\u0131nda ilk s\u0131ralarda yer al\u0131yor. B\u00fcnyesindeki sa\u011fl\u0131k temal\u0131 akademik birimleri ile bir yandan insan ve toplum sa\u011fl\u0131\u011f\u0131na y\u00f6nelik tan\u0131 ve tedavi hizmeti sunarken di\u011fer yandan da y\u00fcr\u00fct\u00fclen bilim \u00e7al\u0131\u015fmalarla literat\u00fcre \u00f6nemli katk\u0131lar sunuyor. Bu kapsamda T\u0131p Fak\u00fcltemiz \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Bur\u00e7in Kaymaz\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131, multidisipliner bilim ekibi taraf\u0131ndan haz\u0131rlanan proje T\u00dcB\u0130TAK taraf\u0131ndan desteklenmeye uygun bulundu.\u00a0\u00a0 T\u00fcrkiye Y\u00fczy\u0131l\u0131\u2019nda \u00fcniversitemizi sa\u011fl\u0131k alan\u0131nda d\u00fcnyan\u0131n referans ald\u0131\u011f\u0131 bir sa\u011fl\u0131k merkezi konumuna y\u00fckselmesine katk\u0131 sunan hocam\u0131z\u0131 ve ekibini \u00e7al\u0131\u015fmalar\u0131ndan dolay\u0131 tebrik ediyorum. Tam akredite bir ara\u015ft\u0131rma \u00fcniversitesi olarak sa\u011fl\u0131k temal\u0131 \u00e7al\u0131\u015fmalar\u0131m\u0131z\u0131 t\u00fcm birimlerimizle multidisipliner bir \u015fekilde s\u00fcrd\u00fcrmeye devam edece\u011fiz\u201d dedi.<\/p>\n

Proje hakk\u0131nda bilgi veren Do\u00e7. Dr. Bur\u00e7in Kaymaz, \u201cBu proje kapsam\u0131nda yeni tasar\u0131m sentetik kannabinoidlerin (4F-MDMB-BUTICA, ADB-BUTINACA, MDMB-4en-PINACA ve daha eski JWH-018) tekil ve tirozin kinaz inhibit\u00f6r\u00fc \u0130matinib ile kombinasyonlu terap\u00f6tik \u00e7al\u0131\u015fmalar\u0131, sa\u011fl\u0131kl\u0131 kontrol lenfosit h\u00fccre hatt\u0131 NCIBL2171, \u0130matinib yan\u0131tl\u0131 K562 ve \u0130matinib\u2019 e diren\u00e7 kazand\u0131r\u0131lm\u0131\u015f K562\/\u0130ma1.2 KML h\u00fccre modellerinde ger\u00e7ekle\u015ftirilecektir. \u0130la\u00e7 direncini k\u0131rma ve sa\u011fl\u0131kl\u0131 h\u00fccrelerin maruz kald\u0131\u011f\u0131 ila\u00e7 toksisitesi azaltma amac\u0131yla bu proje kapsam\u0131nda biyouyumlu \u00e7inko tabanl\u0131 metal-organik kafesler ila\u00e7 ta\u015f\u0131ma sistemi olarak kullan\u0131lacakt\u0131r. Bu ila\u00e7 ta\u015f\u0131ma sistemi ile sa\u011fl\u0131kl\u0131 h\u00fccrelere ila\u00e7 sal\u0131n\u0131m\u0131n\u0131n engellenmesi, ila\u00e7 etkinli\u011finin sadece kanserli h\u00fccrelerde g\u00f6r\u00fclmesi beklenmektedir. Projede kullan\u0131lan sentetik kannabinoidlerin BCR::ABL1 onkojenik kimerik proteinini hedef almas\u0131n\u0131 ama\u00e7lamaktad\u0131r. Bu ba\u011flamda ger\u00e7ekle\u015ftirilen in-silico molek\u00fcler kenetleme \u00e7al\u0131\u015fmalar\u0131 ile, se\u00e7ilen SK\u2019lerin BCR::ABL1\u2019 e ba\u011flanma afinitesi saptanm\u0131\u015f ve \u0130matinib\u2019in ba\u011flanma afinitesi ile kar\u015f\u0131la\u015ft\u0131r\u0131larak terap\u00f6tik etkide bulunaca\u011f\u0131 \u00f6nbulgu olarak g\u00f6sterilmi\u015ftir. Bu ama\u00e7la ger\u00e7ekle\u015ftirilecek sitotoksisite ve kombinasyon analizleri, apoptotik-h\u00fccre d\u00f6ng\u00fcs\u00fc tutulmas\u0131-ROS deteksiyonu analizleri sonras\u0131nda proteomiks ve RNASeq-dizileme sonu\u00e7lar\u0131n\u0131n biyoinformatik analizlerle entegrasyonu ile SK\u2019lerin tekil ve kombinasyon terap\u00f6tik etkinlikleri belirlenecektir. Multidisipliner bir yakla\u015f\u0131mla haz\u0131rlad\u0131\u011f\u0131m\u0131z bu proje \u00f6nerisindeki analizlerle in vitro olarak belirlenen \u0130matinib ila\u00e7 yan\u0131t\u0131 ve direncine ili\u015fkin potansiyel hedef genler ve\/veya yolaklar ile hasta \u00f6rne\u011fi veri setleri aras\u0131nda bir korelasyon olup olmad\u0131\u011f\u0131 ara\u015ft\u0131r\u0131lacak ve klinik ba\u011flant\u0131 ilk kez ortaya konacakt\u0131r\u201d dedi.<\/p>\n

\u201cProje multidisipliner bilim ekibi taraf\u0131ndan haz\u0131rland\u0131\u201d<\/b><\/p>\n

Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Do\u00e7. Dr. Bur\u00e7in Kaymaz\u2019\u0131n yapt\u0131\u011f\u0131 proje ekibinde; \u0130YTE Fen Fak\u00fcltesi Kimya ABD \u00f6\u011fretim \u00fcyesi Prof. Dr. G\u00fcl\u015fah \u015eanl\u0131 ve Ara\u015f. G\u00f6r. Ezgi Vural, \u0130E\u00dc M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik \u00f6\u011fretim \u00fcyesi Dr. \u00d6\u011fr. \u00dcyesi Ya\u011fmur Kiraz Durmaz ve y\u00fcksek lisans \u00f6\u011frencisi Tu\u011fba Yeni, E\u00dc Madde Ba\u011f\u0131ml\u0131l\u0131\u011f\u0131, Toksikoloji ve \u0130la\u00e7 Bilimleri Enstit\u00fcs\u00fc \u00f6\u011fretim \u00fcyesi Prof. Dr. Serap Annette Akg\u00fcr, E\u00dc T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji ABD Doktora \u00d6\u011frencisi H\u00fclya \u00c7inar ve Dr. Ecz. Fazilet Esra D\u00fczda\u011f yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0Ege \u00dcniversitesinin sa\u011fl\u0131k temal\u0131 projeleri T\u00dcB\u0130TAK\u2019tan destek almaya devam ediyor Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi…<\/p>\n","protected":false},"author":2,"featured_media":28598,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70],"tags":[],"class_list":["post-28597","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak.jpg",1500,844,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak-300x169.jpg",300,169,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak-768x432.jpg",640,360,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak-1024x576.jpg",640,360,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak.jpg",1500,844,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak.jpg",1500,844,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak-1024x576.jpg",1024,576,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/06\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr-Necdet-Budak-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a>","tag_info":"Kamp\u00fcs","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/28597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=28597"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/28597\/revisions"}],"predecessor-version":[{"id":28599,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/28597\/revisions\/28599"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/28598"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=28597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=28597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=28597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}