Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Eczac\u0131l\u0131k Teknolojisi B\u00f6l\u00fcm\u00fc Radyofarmasi Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Meliha Ekinci\u2019nin y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cRadyoi\u015faretli Fulvestrant \u0130\u00e7eren Niozom Form\u00fclasyonlar\u0131n\u0131n Meme Kanserini G\u00f6r\u00fcnt\u00fcleme Potansiyelinin in vivo \u00c7al\u0131\u015fmalar ile De\u011ferlendirilmesi\u201d ba\u015fl\u0131kl\u0131 proje, T\u00dcB\u0130TAK 1002 A H\u0131zl\u0131 Destek Mod\u00fcl\u00fc kapsam\u0131nda desteklenmeye uygun bulundu. Proje ile meme kanserinin erken tan\u0131s\u0131na y\u00f6nelik yenilik\u00e7i bir yakla\u015f\u0131m sunulacak.<\/p>\n
Proje ekibini tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201cTam akredite, sa\u011fl\u0131k temal\u0131 ara\u015ft\u0131rma \u00fcniversitemiz, sa\u011fl\u0131k alan\u0131nda yenilik\u00e7i projeler \u00fcretmeye devam ediyor. Kad\u0131nlarda en s\u0131k g\u00f6r\u00fclen kanser t\u00fcr\u00fc olan meme kanserinin erken tan\u0131s\u0131na y\u00f6nelik ger\u00e7ekle\u015ftirdikleri projeleri T\u00dcB\u0130TAK taraf\u0131ndan kabul g\u00f6ren Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim \u00fcyemiz Do\u00e7. Dr. Meliha Ekinci ve ekibini tebrik ediyor, ba\u015far\u0131lar\u0131n\u0131n devam\u0131n\u0131 diliyorum\u201d dedi.<\/p>\n
Kanser hastal\u0131\u011f\u0131nda erken tedavinin \u00f6nemine dikkat \u00e7eken Do\u00e7. Dr. Meliha Ekinci, \u201cD\u00fcnya genelinde \u00f6l\u00fcme en \u00e7ok neden olan hastal\u0131k kanserdir. Kanserin erken evrede, h\u0131zl\u0131 ve do\u011fru te\u015fhisi ve tedavisi hastal\u0131\u011f\u0131n tedavi masraf\u0131n\u0131, tedavi s\u00fcresini, mortalite ve morbidite riskini de \u00f6nemli \u00f6l\u00e7\u00fcde azaltmaktad\u0131r. Bu ama\u00e7la pek \u00e7ok ara\u015ft\u0131rmac\u0131, kanser h\u00fccresine spesifik pasif veya aktif olarak hedeflendirilmi\u015f yeni ila\u00e7lar geli\u015ftirmeye \u00e7al\u0131\u015fmaktad\u0131r. Pasif hedeflendirme ile aktif hedeflendirmenin bir arada kullan\u0131m\u0131, ila\u00e7 hedeflendirmenin en etkili \u015feklidir. Nanota\u015f\u0131y\u0131c\u0131, artm\u0131\u015f ge\u00e7irgenlik ve al\u0131konma etkisi ile \u00f6nce hasta b\u00f6lgede toplan\u0131rken, kanser h\u00fccrelerinin y\u00fczeylerindeki artm\u0131\u015f resept\u00f6r say\u0131lar\u0131 hedef al\u0131narak aktif olarak hedeflendirilmi\u015f form\u00fclasyon ile ilac\u0131n h\u00fccrelerin i\u00e7ine ula\u015fmas\u0131 sa\u011flan\u0131r. \u0130la\u00e7 geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131nda form\u00fclasyonun in vitro h\u00fccre k\u00fclt\u00fcr\u00fc ve in vivo ortamdaki davran\u0131\u015flar\u0131n\u0131 takip etmek amac\u0131yla \u00f6zellikle klinik \u00f6ncesi d\u00fczeyde yeni ila\u00e7lar\u0131n veya mevcut ila\u00e7lar\u0131n yeni form\u00fclasyonlar\u0131n\u0131n karakterizasyonu i\u00e7in g\u00f6r\u00fcnt\u00fcleme teknikleri kullan\u0131labilmektedir. Anatomik g\u00f6r\u00fcnt\u00fcleme teknikleri, morfolojik de\u011fi\u015fikliklere dayand\u0131\u011f\u0131 i\u00e7in hastal\u0131\u011f\u0131n ilk a\u015famas\u0131ndaki g\u00f6r\u00fcnt\u00fclemede yeterli de\u011fildir. Oysa sintigrafik g\u00f6r\u00fcnt\u00fcleme, fizyolojik de\u011fi\u015fikliklerin tespitine dayanan non-invaziv bir g\u00f6r\u00fcnt\u00fcleme tekni\u011fi oldu\u011fundan erken evrede te\u015fhise imk\u00e2n vermektedir\u201d dedi.<\/p>\n
\u201cMeme kanserinin erken tan\u0131s\u0131 b\u00fcy\u00fck \u00f6nem ta\u015f\u0131yor\u201d<\/b><\/p>\n
Meme kanserinin kad\u0131nlarda s\u0131k g\u00f6r\u00fcld\u00fc\u011f\u00fcn\u00fc ifade eden Do\u00e7. Dr. Ekinci, \u201cMeme kanseri kad\u0131nlarda en s\u0131k g\u00f6r\u00fclen kanser t\u00fcr\u00fcd\u00fcr. Son derece h\u0131zl\u0131 metastaz yapmas\u0131 nedeniyle meme kanserinin erken tan\u0131s\u0131 b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r. Ara\u015ft\u0131rmac\u0131lar, meme kanseri h\u00fccresine spesifik yeni radyofarmas\u00f6tikler geli\u015ftirmeye \u00e7al\u0131\u015fmaktad\u0131r. Meme kanseri vakalar\u0131nda \u00f6strojen resept\u00f6r\u00fc (ER), progesteron resept\u00f6r\u00fc (PR), folat resept\u00f6r\u00fc veya insan epidermal b\u00fcy\u00fcme fakt\u00f6r\u00fc resept\u00f6r\u00fc 2\u2019nin (HER2) a\u015f\u0131r\u0131 eksprese edildi\u011fi vurgulanmaktad\u0131r. Bu durum, bu resept\u00f6rleri meme t\u00fcm\u00f6r\u00fc dokusunu hedefleme amac\u0131 ile kullan\u0131labilecek muhtemel hedefler haline getirmektedir. Fulvestrant, 2002 y\u0131l\u0131nda FDA taraf\u0131ndan meme kanserinin tedavisi i\u00e7in onay alm\u0131\u015f yeni nesil bir \u00f6strojen resept\u00f6r antagonistidir. \u00d6strojen hormonunun kendi resept\u00f6rlerine ba\u011flanmas\u0131n\u0131 engellemekte ve b\u00f6ylece h\u00fccre i\u00e7ine b\u00fcy\u00fcme ve \u00e7o\u011falma sinyalinin g\u00f6nderilmesini bask\u0131lamaktad\u0131r\u201d diye konu\u015ftu.<\/p>\n
Do\u00e7. Dr. Ekinci, \u201cProje kapsam\u0131nda, fulvestrant\u0131n meme kanseri h\u00fccresine afinitesinden faydalanarak kanser tan\u0131s\u0131nda kullan\u0131lma potansiyelinin de\u011ferlendirilmesi planlanmaktad\u0131r. Bu kapsamda fulvestrant i\u00e7eren niozomal form\u00fclasyonlar, Teknesyum-99m ile radyoi\u015faretlenerek yeni bir radyofarmas\u00f6tik geli\u015ftirilecektir. Geli\u015ftirilen radyofarmas\u00f6ti\u011fin meme kanseri h\u00fccrelerine afinitesi, ger\u00e7ekle\u015ftirilecek olan h\u00fccre k\u00fclt\u00fcr\u00fc ve in vivo biyoda\u011f\u0131l\u0131m \u00e7al\u0131\u015fmalar\u0131 ile belirlenecektir\u201d dedi.<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Eczac\u0131l\u0131k Teknolojisi B\u00f6l\u00fcm\u00fc Radyofarmasi Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Meliha…<\/p>\n","protected":false},"author":2,"featured_media":26325,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-26324","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/03\/Egeli-bilim-insanindan-meme-kanserinin-erken-tanisina-yonelik-yenilikci-proje-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/26324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=26324"}],"version-history":[{"count":2,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/26324\/revisions"}],"predecessor-version":[{"id":26327,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/26324\/revisions\/26327"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/26325"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=26324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=26324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=26324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}