Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Bur\u00e7in Kaymaz\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cTirozin Kinaz \u0130nhibit\u00f6r\u00fc \u0130matinib\u2019e Diren\u00e7li KML Tan\u0131l\u0131 Olgularda\u00a0Progenit\u00f6r K\u00f6k H\u00fccrelerin Ex Vivo K\u00fclt\u00fcr\u00fcnde STAT5 \u0130nhibisyonu Arac\u0131l\u0131 Tedavi Stratejisinin RNA Dizileme Analizi Verilerinin Yapay Zeka Tabanl\u0131 Ara\u015ft\u0131r\u0131lmas\u0131\u201d ba\u015fl\u0131kl\u0131 proje T\u00dcSEB B Grubu Ar-Ge Proje \u00c7a\u011fr\u0131lar\u0131 kapsam\u0131nda desteklenmeye uygun bulundu. Proje ile kronik myeloid l\u00f6semi hastal\u0131\u011f\u0131n\u0131n tedavisinde kullan\u0131lan \u0130matinib ilac\u0131na kar\u015f\u0131 diren\u00e7 geli\u015ftirilmesi ara\u015ft\u0131r\u0131lacak.<\/p>\n
Proje ekibini makam\u0131nda a\u011f\u0131rlayan Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201cSa\u011fl\u0131k alan\u0131nda ger\u00e7ekle\u015ftirdi\u011fi \u00f6nc\u00fc \u00e7al\u0131\u015fmalarla dikkat ge\u00e7en \u00fcniversitemiz akademisyenlerinin projeleri, \u00e7e\u015fitli kurum ve kurulu\u015flar\u0131n \u00e7a\u011fr\u0131lar\u0131 kapsam\u0131nda desteklenmeye devam ediyor. T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyemiz Do\u00e7. Dr. Bur\u00e7in Kaymaz ve ekibinin ger\u00e7ekle\u015ftirdi\u011fi proje T\u00fcrk Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131\u2019n\u0131n \u00e7a\u011fr\u0131s\u0131 kapsam\u0131nda desteklenmeye uygun g\u00f6r\u00fcld\u00fc. Hocam\u0131z\u0131 ve ekibini tebrik ediyorum\u201d dedi.<\/p>\n
Proje hakk\u0131nda bilgi veren Do\u00e7. Dr. Bur\u00e7in Kaymaz, \u201cBu proje, STAT5 inhibit\u00f6r\u00fc Pimozide\u2019in STAT5 aktivasyonunu inhibe etmesiyle; \u0130matinib diren\u00e7li kronik myeloid l\u00f6semi (KML) tan\u0131l\u0131 olgular\u0131n hematopoietik\u00a0k\u00f6k h\u00fccrelerinde, \u0130matinib ile kombinasyon terapisinin etkinli\u011finin RNA dizileme analiziyle yapay zeka destekli olarak belirlenebilmesi\u00a0\u00fczerine tasarlanm\u0131\u015ft\u0131r.\u00a0Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi Hematoloji Klini\u011finde 2013-2024 y\u0131llar\u0131 aras\u0131nda takipli, \u0130matinib tedavisi ba\u015flanmam\u0131\u015f yeni tan\u0131, \u0130matinib yan\u0131tl\u0131, \u0130matib diren\u00e7li KML tan\u0131l\u0131 olgular\u0131n kan \u00f6rneklerinden CD34+ hematopoietik k\u00f6k h\u00fccrelerin 3D sferoid k\u00fclt\u00fcrde \u00e7o\u011falt\u0131lmas\u0131 sonras\u0131nda RNA dizileme analiziyle genom geneli mRNA Transkriptom ekspresyon profillemesi ger\u00e7ekle\u015ftirilecektir. Verilerin\u00a0biyoinformatik analizleri a\u00e7\u0131k eri\u015fim veritabanlar\u0131 GEO ve TCGA \u00fczerinden,\u00a0KML’ de\u00a0diren\u00e7 geli\u015fimi \u00fczerine etkin\u00a0modellerin ve\u00a0biyobelirte\u00e7lerin belirlenebilmesi\u00a0ise genetik algoritmalar, bulan\u0131k sistemler, makine ve derin \u00f6\u011frenme y\u00f6ntemlerini i\u00e7eren yapay zeka tabanl\u0131 hibrit bir yaz\u0131l\u0131m arac\u0131l\u0131\u011f\u0131yla geli\u015ftirilecektir. Projenin sonucunda\u00a0Pimozide\u2019in STAT5 inhibit\u00f6r etkisinin molek\u00fcler hedeflerinin tan\u0131mlanmas\u0131yla, \u0130matinib direnci geli\u015fim\u00a0mekanizmas\u0131n\u0131n ayd\u0131nlat\u0131lmas\u0131na b\u00fcy\u00fck bir katk\u0131 sa\u011flanm\u0131\u015f olacakt\u0131r. Kemosensitivitenin geri kazan\u0131lmas\u0131 i\u00e7in yapay zeka destekli analizlerle yeni tan\u0131\u00a0vakalar\u0131n olas\u0131 diren\u00e7 geli\u015fiminin \u00f6ng\u00f6r\u00fclmesi, diren\u00e7li olgularda kombinasyon tedavi uygulamas\u0131 sayesinde direncin \u00fcstesinden gelinmesine y\u00f6nelik biyobelirte\u00e7lerin tan\u0131mlanmas\u0131yla y\u00fcksek bir toplumsal ve global yayg\u0131n etkinin sa\u011flanmas\u0131\u00a0hedeflenmi\u015ftir\u201d dedi.<\/p>\n
Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Do\u00e7. Dr. Bur\u00e7in Kaymaz\u2019\u0131n yapt\u0131\u011f\u0131 proje ekibinde;\u00a0 E\u00dc T\u0131p Fak\u00fcltesi \u0130\u00e7 Hastal\u0131klar\u0131 Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyeleri Prof. Dr. G\u00fcray Saydam ve Do\u00e7. Dr. Nur Soyer, Band\u0131rma Onyedi Eyl\u00fcl \u00dcniversitesi T\u0131p Fak\u00fcltesi Dekan Yard\u0131mc\u0131s\u0131 Do\u00e7. Dr. \u00c7a\u011fda\u015f Aktan,\u00a0 Mimar Sinan G\u00fczel Sanatlar \u00dcniversitesi\u00a0 \u0130statistik B\u00f6l\u00fcm\u00fc \u00f6\u011fretim\u00a0 \u00fcyesi Prof. Dr. Ozan Kocada\u011fl\u0131, Uzm. Dr. Fatma Keklik Karada\u011f ve Uzm Ecz. Fazilet Esra D\u00fczda\u011f yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Bur\u00e7in Kaymaz\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc…<\/p>\n","protected":false},"author":2,"featured_media":25310,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70],"tags":[],"class_list":["post-25301","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2025\/01\/Doc.Dr_.Burcin-Kaymaz-Prof.-Dr.-Necdet-Budak-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a>","tag_info":"Kamp\u00fcs","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/25301","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=25301"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/25301\/revisions"}],"predecessor-version":[{"id":25312,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/25301\/revisions\/25312"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/25310"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=25301"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=25301"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=25301"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}