{"id":23845,"date":"2024-10-23T05:08:00","date_gmt":"2024-10-23T05:08:00","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=23845"},"modified":"2024-10-23T07:09:35","modified_gmt":"2024-10-23T07:09:35","slug":"ege-universitesinden-kansere-yonelik-onemli-bir-proje-daha","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2024\/10\/23\/ege-universitesinden-kansere-yonelik-onemli-bir-proje-daha\/","title":{"rendered":"Ege \u00dcniversitesinden kansere y\u00f6nelik \u00f6nemli bir proje daha\u2026"},"content":{"rendered":"

“GBM Tedavisinde \u00c7\u0131\u011f\u0131r A\u00e7acak Proje: Uzun Kodlamayan RNA’n\u0131n Rol\u00fc \u0130nceleniyor”<\/strong><\/p>\n

Egeli bilim insanlar\u0131n\u0131n projeleri T\u00dcB\u0130TAK taraf\u0131ndan desteklenmeye devam ediyor. Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc\u00a0<\/b>Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. \u00c7\u0131\u011f\u0131r Biray Avc\u0131\u2019n\u0131n \u00fcstlendi\u011fi, \u201cLncRNA Linc01551’in Hedef Gen Profilinin \u0130ncelenmesi ve Gbm Progresyonundaki Rol\u00fcn\u00fcn Epitelyal-Mezenkimal Ge\u00e7i\u015f Yolu \u00dczerinden Ara\u015ft\u0131r\u0131lmas\u0131\u201d ba\u015fl\u0131kl\u0131 proje, T\u00dcB\u0130TAK -ARDEB \u201c1001-Bilimsel ve Teknolojik Ara\u015ft\u0131rma Projelerini Destekleme Program\u0131\u201d kapsam\u0131nda desteklenmeye uygun bulundu.<\/p>\n

Proje kapsam\u0131nda Egeli bilim ekibi, bir t\u00fcr beyin kanseri olarak bilinen Glioblastoma (GBM) \u00fczerine \u00f6nemli \u00e7al\u0131\u015fmalar y\u00fcr\u00fctecek. E\u00dc Histoloji ve Embriyoloji Anabilim Dal\u0131\u2019ndan Prof. Dr. H\u00fcseyin Altu\u011f, Ayd\u0131n Adnan Menderes \u00dcniversitesi T\u0131bbi Biyoloji Anabilim Dal\u0131\u2019ndan Do\u00e7. Dr. Bakiye G\u00f6ker\u2019in yer ald\u0131\u011f\u0131 projenin ara\u015ft\u0131rma aya\u011f\u0131nda ise E\u00dc Onkoloji ve T\u0131bbi Biyoloji doktora \u00f6\u011frencileri Elham Shahriyari ile Asghar Khalilnezhad yer al\u0131yor. Projenin yurt d\u0131\u015f\u0131 dan\u0131\u015fmanl\u0131\u011f\u0131n\u0131 ise Harvard \u00dcniversitesi Brigham and Women\u2019s Hospital\u2019dan Dr. Ahad Khalilnezhad Zeinabad \u00fcstleniyor.<\/p>\n

Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, proje y\u00fcr\u00fct\u00fcc\u00fcs\u00fc Prof. Dr. \u00c7\u0131\u011f\u0131r Biray Avc\u0131\u2019y\u0131 makam\u0131nda a\u011f\u0131rlayarak \u00e7al\u0131\u015fmalar\u0131 hakk\u0131nda bilgi ald\u0131. Bir k\u00fclt\u00fcr haline getirdikleri bilim \u00fcretme ekosisteminin somut \u00e7\u0131kt\u0131lara d\u00f6n\u00fc\u015fmesinden b\u00fcy\u00fck mutluluk duyduklar\u0131n\u0131 ifade eden Rekt\u00f6r Prof. Dr. Budak, proje ekibine \u00e7al\u0131\u015fmalar\u0131nda ba\u015far\u0131lar diledi.<\/p>\n

\u201cRNA’lar kanserin olu\u015fumu ve tedavi direncinde \u00f6nemli rol oynuyor\u201d<\/b><\/p>\n

Proje hakk\u0131nda bilgi veren Prof. Dr. \u00c7\u0131\u011f\u0131r Biray Ac\u0131, \u201cProjemiz, uzun kodlamayan RNA molek\u00fcllerinden biri olan LINC01551’in rol\u00fcn\u00fc ve bu molek\u00fcl\u00fcn kanserin ilerlemesinde nas\u0131l etkili oldu\u011funu incelemeyi ama\u00e7l\u0131yor. \u00a0Glioblastoma (GBM), molek\u00fcler yap\u0131daki karma\u015f\u0131kl\u0131\u011f\u0131 nedeniyle tedavisi zor bir kanser t\u00fcr\u00fc olarak bilinmektedir. Son y\u0131llarda kullan\u0131lmaya ba\u015flanan Tek H\u00fccre RNA Sekanslama (scRNA-seq) teknolojisi, kanser gibi hastal\u0131klar\u0131n ara\u015ft\u0131r\u0131lmas\u0131nda b\u00fcy\u00fck bir ilerleme sa\u011flam\u0131\u015ft\u0131r. Bu teknoloji, genlerin ve uzun kodlamayan RNA’lar\u0131n h\u00fccre d\u00fczeyindeki ifade profilini analiz ederek kanserin i\u00e7sel farkl\u0131l\u0131klar\u0131n\u0131 ortaya \u00e7\u0131karmaya olanak tan\u0131r. Yap\u0131lan son ara\u015ft\u0131rmalar, protein kodlayan genlerin yan\u0131 s\u0131ra uzun kodlamayan RNA’lar\u0131n da kanserin olu\u015fumu, ilerlemesi ve tedavi direncinde \u00f6nemli rol oynayabilece\u011fini g\u00f6stermektedir. Bu \u00e7al\u0131\u015fma kapsam\u0131nda, 14 GBM hastas\u0131na ait tek h\u00fccre RNA sekanslama verileri kullan\u0131larak 12.133 farkl\u0131 uzun kodlamayan RNA molek\u00fcl\u00fcn\u00fcn ifade d\u00fczeyleri incelenmi\u015ftir. Yap\u0131lan analizler sonucunda, LINC01551 adl\u0131 uzun kodlamayan RNA molek\u00fcl\u00fcn\u00fcn GBM hastalar\u0131nda \u00f6nemli bir rol oynad\u0131\u011f\u0131 ve bu molek\u00fcl\u00fcn kanserin k\u00f6t\u00fcle\u015fmesinde epitelyal-mezenkimal ge\u00e7i\u015f yoluyla etkili oldu\u011fu belirlenmi\u015ftir. Ayr\u0131ca yap\u0131lan korelasyon analizleri, LINC01551’in beyin dokusunda en az 154 genin ifade d\u00fczeyini etkileyebilece\u011fini g\u00f6stermi\u015ftir\u201d dedi.<\/p>\n

Prof. Dr. Biray Avc\u0131, \u201cBu \u00e7al\u0131\u015fman\u0131n deneysel a\u015famas\u0131nda, LINC01551’in etkilerini daha iyi anlamak i\u00e7in CRISPR-Cas9 gibi yeni teknikler kullan\u0131lacak ve bu molek\u00fcl\u00fcn etkiledi\u011fi gen profili hem laboratuvar ortam\u0131nda hem de fare modelleri \u00fczerinde incelenecektir. Elde edilen bulgular, Sanger dizileme, RT-qPCR ve Western Blot gibi y\u00f6ntemlerle do\u011frulanacakt\u0131r. Bu bulgular\u0131n, LINC01551’in fizyolojik ve patofizyolojik rollerini anlamam\u0131za yard\u0131mc\u0131 olmas\u0131 ve GBM’nin geli\u015fimindeki etkilerini anlamak a\u00e7\u0131s\u0131ndan \u00f6nemli oldu\u011fu d\u00fc\u015f\u00fcn\u00fclmektedir\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"

“GBM Tedavisinde \u00c7\u0131\u011f\u0131r A\u00e7acak Proje: Uzun Kodlamayan RNA’n\u0131n Rol\u00fc \u0130nceleniyor” Egeli bilim insanlar\u0131n\u0131n projeleri T\u00dcB\u0130TAK…<\/p>\n","protected":false},"author":2,"featured_media":23846,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70],"tags":[],"class_list":["post-23845","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/10\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a>","tag_info":"Kamp\u00fcs","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/23845","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=23845"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/23845\/revisions"}],"predecessor-version":[{"id":23847,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/23845\/revisions\/23847"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/23846"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=23845"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=23845"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=23845"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}