Ege \u00dcniversitesi Fen Fak\u00fcltesi Biyoloji B\u00f6l\u00fcm\u00fc Molek\u00fcler Biyoloji Anabilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. H\u00fcseyin Can\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cToxoplasma gondii SAG1, MIC1, ROP6, GRA1, SRS9 ve SporoSAG mRNA a\u015f\u0131 transkriptlerini i\u00e7eren miks mRNA a\u015f\u0131s\u0131 yakla\u015f\u0131m\u0131 ile toksoplazmozise kar\u015f\u0131 koruyucu yeni nesil biyoteknolojik a\u015f\u0131 geli\u015ftirilmesi\u201d ba\u015fl\u0131kl\u0131 proje, T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu (T\u00dcB\u0130TAK) taraf\u0131ndan desteklenmeye uygun bulundu. Proje ile \u00f6zellikle hamilelerde ve ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 zay\u0131f insan ve hayvanlarda tehlikeli sonu\u00e7lar do\u011furabilen \u201cToksoplazma\u201d enfeksiyonuna kar\u015f\u0131 mRNA a\u015f\u0131s\u0131 geli\u015ftirme ama\u00e7lan\u0131yor.<\/p>\n
Proje ekibini makam\u0131nda a\u011f\u0131rlayarak tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak,\u201cK\u0131sa s\u00fcre \u00f6nce t\u00fcm d\u00fcnyay\u0131 derinden etkileyen pandemi s\u00fcreci bizlere a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131n\u0131n ne kadar k\u0131ymetli oldu\u011funu g\u00f6sterdi. Tam akreditasyona sahip ara\u015ft\u0131rma \u00fcniversitemiz akademisyenleri, multidipliner bir anlay\u0131\u015f ve i\u015f birli\u011fi ile \u00a0Toksoplazma enfeksiyonuna y\u00f6nelik a\u015f\u0131 geli\u015ftirecekler. Temel bilimler ve sa\u011fl\u0131k alanlar\u0131nda k\u00f6kl\u00fc bir ge\u00e7mi\u015fi bulanan \u00fcniversitemiz b\u00fcnyesinde bu t\u00fcr \u00e7al\u0131\u015fmalar\u0131n ger\u00e7ekle\u015ftirilmesi bizleri ziyadesiyle mutlu ediyor. Bu de\u011ferli \u00e7al\u0131\u015fmalar\u0131 i\u00e7in akademisyenlerimizi tebrik ediyor, \u00e7al\u0131\u015fmalar\u0131nda ba\u015far\u0131lar diliyorum\u201d dedi.<\/p>\n
\u201cBu parazitle m\u00fccadelede a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131na ihtiya\u00e7 var\u201d<\/strong><\/p>\n Projenin amac\u0131n\u0131 anlatan Do\u00e7. Dr. H\u00fcseyin Can, \u201cProjede, insan ve hayvanlar\u0131 enfekte ederek toksoplazmozise neden olan Toxoplasma gondii\u2019ye kar\u015f\u0131 mRNA a\u015f\u0131s\u0131 geli\u015ftirmeyi hedefliyoruz. D\u00fcnyada insan n\u00fcfusunun 3\u2019te 1\u2019inin bu parazit ile enfekte oldu\u011fu tahmin ediliyor. Toksoplazmozisli sa\u011fl\u0131kl\u0131 bireylerde genellikle her hangi bir klinik belirti g\u00f6zlenmezken ba\u011f\u0131\u015f\u0131kl\u0131k sistemi zay\u0131flam\u0131\u015f olanlarda ciddi \u00f6l\u00fcmle sonu\u00e7lanabilen durumlar ortaya \u00e7\u0131kabilmekte. Ayr\u0131ca, hamilelik d\u00f6neminde al\u0131nd\u0131\u011f\u0131nda fet\u00fcse ge\u00e7erek d\u00fc\u015f\u00fcklere ve do\u011fumsal anomalilere de neden olabilmekte. Di\u011fer taraftan veterinerlik alan\u0131nda da s\u0131kl\u0131kla koyunlarda d\u00fc\u015f\u00fcklere sebep olarak ciddi ekonomik kay\u0131plara yol a\u00e7\u0131yor. \u0130nsanlarda ve hayvanlarda kronik enfeksiyona sebep olan doku kistlerinin tedavisine y\u00f6nelik etkin bir ilac\u0131n olmamas\u0131 sebebiyle bu parazitle m\u00fccadelede a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131na ihtiya\u00e7 var. G\u00fcn\u00fcm\u00fczde sadece koyunlarda kullan\u0131m\u0131 ruhsatland\u0131r\u0131lm\u0131\u015f Toxovax a\u015f\u0131s\u0131n\u0131n var olmas\u0131, toksoplasmozise kar\u015f\u0131 etkin a\u015f\u0131 geli\u015ftirilebilece\u011fini g\u00f6steriyor\u201d dedi.<\/p>\n \u201cmRNA a\u015f\u0131 teknolojisinin parazitler i\u00e7in kullan\u0131labilece\u011fi g\u00f6sterilecek\u201d<\/strong><\/p>\n mRNA a\u015f\u0131lar\u0131n\u0131n koronavir\u00fcs pandemisinde ba\u015far\u0131yla uyguland\u0131\u011f\u0131n\u0131 dile getiren Do\u00e7. Dr. Can, \u201cG\u00fcn\u00fcm\u00fczde COVID-19 pandemisine kar\u015f\u0131 kullan\u0131lan \u2018mRNA a\u015f\u0131 platformu\u2019 geni\u015f kitlelere ba\u015far\u0131l\u0131 bir \u015fekilde uygulanm\u0131\u015ft\u0131r. Bu sebeple de di\u011fer bula\u015f\u0131c\u0131 patojenlere kar\u015f\u0131 ba\u015far\u0131s\u0131n\u0131n h\u0131zl\u0131ca test edilece\u011fi a\u00e7\u0131kt\u0131r. Projemiz kapsam\u0131nda \u2018Toxoplasma gondii\u2019ye kar\u015f\u0131 multivalan mRNA a\u015f\u0131s\u0131 geli\u015ftirilmesi\u2019 planlanm\u0131\u015ft\u0131r. Buna ba\u011fl\u0131 olarak projede Toxoplasma gondii SAG1, MIC1, ROP6, GRA1, SRS9 ve SporoSAG proteinlerini sentezleyen mRNA a\u015f\u0131 transkriptleri \u00fcretilecek ve lipit nanopartik\u00fclleri (LNP) ile form\u00fcle edilip farelere mRNA-LNP a\u015f\u0131s\u0131 uygulanacakt\u0131r. Daha sonra, a\u015f\u0131lanm\u0131\u015f fareler Toxoplasma gondii doku kistleri ile enfekte edilerek mRNA-LNP a\u015f\u0131s\u0131n\u0131n\u00a0 koruyuculu\u011fu g\u00f6sterilecektir. Sonu\u00e7 olarak; hem insanlar hem de \u00e7iftlik hayvanlar\u0131 i\u00e7in \u00f6nemli bir parazit olan Toxoplasma gondii\u2019ye kar\u015f\u0131 mRNA-LNP a\u015f\u0131s\u0131n\u0131n\u00a0 etkinli\u011fi deney hayvanlar\u0131nda test edilecektir. Dahas\u0131, bu proje ile birlikte COVID-19\u2019a kar\u015f\u0131 ba\u015far\u0131l\u0131 olan mRNA a\u015f\u0131lar\u0131n\u0131n sadece vir\u00fcslere kar\u015f\u0131 de\u011fil insanlarda salg\u0131nlara neden olabilecek parazitler i\u00e7in de kullan\u0131labilece\u011fi g\u00f6sterilmi\u015f olacak\u201d diye konu\u015ftu.<\/p>\n Do\u00e7. Dr. H\u00fcseyin Can\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 projede, E\u00dc Fen Fak\u00fcltesi Molek\u00fcler Biyoloji Anabilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Prof. Dr. Cemal \u00dcn, \u00a0E\u00dc A\u015f\u0131 Geli\u015ftirme Uygulama ve Ara\u015ft\u0131rma Merkezi \u00d6\u011fretim \u00dcyeleri; Prof. Dr. Y\u00fcksel G\u00fcr\u00fcz, Prof. Dr. Mert D\u00f6\u015fkaya, Do\u00e7. Dr. Aysu De\u011firmenci D\u00f6\u015fkaya, Do\u00e7. Dr. Hasan Akbaba, Do\u00e7. Dr. Muhammet Karakavuk ve Dr. \u00d6zlem G\u00fcnay E\u015fiyok yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":" Ege \u00dcniversitesi Fen Fak\u00fcltesi Biyoloji B\u00f6l\u00fcm\u00fc Molek\u00fcler Biyoloji Anabilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. H\u00fcseyin…<\/p>\n","protected":false},"author":2,"featured_media":23243,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-23242","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/09\/Muhammet-Karakavuk-Yuksel-Guruz-Huseyin-Can-Necdet-Budak-Mert-Doskaya-Aysu-Degirmenci-Doskaya-Ozlem-Gunay-Esiyok-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/23242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=23242"}],"version-history":[{"count":2,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/23242\/revisions"}],"predecessor-version":[{"id":23253,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/23242\/revisions\/23253"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/23243"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=23242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=23242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=23242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}