{"id":23061,"date":"2024-08-28T06:19:04","date_gmt":"2024-08-28T06:19:04","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=23061"},"modified":"2024-08-28T06:20:42","modified_gmt":"2024-08-28T06:20:42","slug":"egeli-akademisyen-ve-ekibi-alzheimer-hastaligi-ile-egzersiz-arasindaki-iliskiyi-inceleyecek","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2024\/08\/28\/egeli-akademisyen-ve-ekibi-alzheimer-hastaligi-ile-egzersiz-arasindaki-iliskiyi-inceleyecek\/","title":{"rendered":"Egeli akademisyen ve ekibi, Alzheimer hastal\u0131\u011f\u0131 ile egzersiz aras\u0131ndaki ili\u015fkiyi inceleyecek"},"content":{"rendered":"

\u201cEXERBRAIN\u201d projesinde Almanya, Hollanda ve \u0130spanya\u2019dan\u00a0 akademisyenler\u00a0 de yer al\u0131yor<\/span><\/p>\n

Egeli akademisyen ve ekibi, Alzheimer hastal\u0131\u011f\u0131 ile egzersiz aras\u0131ndaki ili\u015fkiyi inceleyecek<\/span><\/b><\/p>\n

*<\/span><\/b>\u00a0<\/span>Alzheimer hastal\u0131\u011f\u0131n\u0131n, ya\u015flanan n\u00fcfus \u00fczerinde b\u00fcy\u00fck bir duygusal ve mali y\u00fck olu\u015fturdu\u011funu ifade eden Prof. Dr. Biray Avc\u0131, \u201c\u015eu anda hastal\u0131\u011f\u0131 de\u011fi\u015ftirici etkili bir ila\u00e7 mevcut olmasa da, fiziksel egzersizin bilinmeyen mekanizmalar yoluyla Alzheimer hastal\u0131\u011f\u0131dan korudu\u011fu g\u00f6sterilmi\u015ftir\u201d dedi.<\/b><\/span><\/p>\n

Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi(E\u00dcTF) T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. \u00c7\u0131\u011f\u0131r Biray Avc\u0131\u2019n\u0131n \u201cAlzheimer Hastal\u0131\u011f\u0131na Kar\u015f\u0131 Korumada Egzersiz ve Beyin Lipit Metabolizmas\u0131 Aras\u0131ndaki Etkile\u015fim- EXERBRAIN\u201d ba\u015fl\u0131kl\u0131 projesi, N\u00f6rodejeneratif Hastal\u0131k Ara\u015ft\u0131rmalar\u0131 Ortak Program\u0131 (JPCOFUND) \u201cN\u00f6rodejeneratif Hastal\u0131klar\u0131n Erken Evresinde Hastal\u0131k Progresyonunun De\u011ferlendirilmesi ve Mekanizmalar\u0131n\u0131n \u0130ncelenmesi\u201d \u00e7a\u011fr\u0131s\u0131 kapsam\u0131nda kabul edildi.<\/span><\/p>\n

Proje ayr\u0131ca, \u201cT\u00dcB\u0130TAK 1071 Uluslararas\u0131 Ara\u015ft\u0131rma Fonlar\u0131ndan Yararlanma Kapasitesinin ve Uluslararas\u0131 Ar-Ge \u0130\u015fbirliklerine Kat\u0131l\u0131m\u0131n Artt\u0131r\u0131lmas\u0131na Y\u00f6nelik Destek Program\u0131\u201d kapsam\u0131nda da desteklenmeye uygun bulundu. Prof. Dr. \u00c7\u0131\u011f\u0131r Biray Avc\u0131\u2019n\u0131n T\u00fcrkiye koordinat\u00f6rl\u00fc\u011f\u00fcnde y\u00fcr\u00fct\u00fclecek \u201cEXERBRAIN\u201d projesinde Almanya, Hollanda ve \u0130spanya\u2019dan bilim insanlar\u0131n\u0131n olu\u015fturduklar\u0131 \u00e7al\u0131\u015fma gruplar\u0131 yer alacak.<\/span><\/p>\n

Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, Prof. Dr. \u00c7\u0131\u011f\u0131r Biray Avc\u0131 ve ekibini makam\u0131nda a\u011f\u0131rlayarak tebrik ederek \u00e7al\u0131\u015fmalar\u0131nda ba\u015far\u0131lar diledi.<\/span><\/p>\n

\u201cAlzheimer, ya\u015fl\u0131 n\u00fcfus \u00fczerinde duygusal ve mali y\u00fck olu\u015fturuyor\u201d<\/span><\/b><\/p>\n

Projenin amac\u0131 ile ilgili bilgi veren Prof. Dr. \u00c7\u0131\u011f\u0131r Biray Avc\u0131, \u201cBu projenin amac\u0131, insan kaynakl\u0131 pluripotent k\u00f6k h\u00fccreden (iPSC) t\u00fcretilmi\u015f beyin h\u00fccrelerinde ve Alzheimer hayvan modellerinde Alzheimer hastal\u0131k patogenezinde beyin lipit metabolizmas\u0131n\u0131n rol\u00fcn\u00fc ara\u015ft\u0131rmak i\u00e7in multi-omik ve b\u00fcy\u00fck veri yakla\u015f\u0131mlar\u0131 kullan\u0131larak n\u00f6rodejeneratif hastal\u0131klar\u0131n karma\u015f\u0131k ve \u00e7ok fakt\u00f6rl\u00fc patogenezinin anla\u015f\u0131lmas\u0131n\u0131 sa\u011flamakt\u0131r\u201d dedi.<\/span><\/p>\n

Alzheimer hastal\u0131\u011f\u0131n\u0131n, ya\u015flanan n\u00fcfus \u00fczerinde b\u00fcy\u00fck bir duygusal ve mali y\u00fck olu\u015fturdu\u011funu ifade eden \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Prof. Dr. Biray Avc\u0131, \u201c\u015eu anda hastal\u0131\u011f\u0131 de\u011fi\u015ftirici etkili bir ila\u00e7 mevcut olmasa da, fiziksel egzersizin bilinmeyen mekanizmalar yoluyla Alzheimer hastal\u0131\u011f\u0131dan korudu\u011fu g\u00f6sterilmi\u015ftir. EXERBRAIN’de, egzersizin Alzheimer hastal\u0131\u011f\u0131 \u00fczerindeki koruyucu etkisinin, Alzheimer hastal\u0131\u011f\u0131nda beyin lipid metabolizmas\u0131n\u0131n normalle\u015fmesi ve ard\u0131ndan lipit kaynakl\u0131 Alzheimer hastal\u0131\u011f\u0131 patogenezindeki azalman\u0131n arac\u0131l\u0131k etti\u011fi transkripsiyonel ve epigenomik de\u011fi\u015fiklikleri single-cell RNA-seq ve single-cell ATAC-seq teknikleri ile ortaya \u00e7\u0131kar\u0131lmas\u0131n\u0131 planlamaktay\u0131z\u201d dedi.<\/span><\/p>\n

\u201cMultidisipliner \u00e7al\u0131\u015fma gruplar\u0131 ile detayl\u0131 ara\u015ft\u0131rma yap\u0131lacak\u201d<\/span><\/b><\/p>\n

Proje kapsam\u0131nda olu\u015fturduklar\u0131 \u00e7al\u0131\u015fma gruplar\u0131n\u0131n yapaca\u011f\u0131 ara\u015ft\u0131rmalardan \u00a0bahseden Prof. Dr. Biray Avc\u0131, \u201cEXERBRAIN konsorsiyumu, egzersizin fare beyni \u00fczerindeki etkilerinin son derece ayr\u0131nt\u0131l\u0131 bir transkripsiyonel, epigenomik ve metabolik haritas\u0131n\u0131 olu\u015fturacak ve bu sonu\u00e7lar\u0131 Alzheimer hastal\u0131\u011f\u0131 riski ta\u015f\u0131yan bir insan kohortunda do\u011frulayacakt\u0131r. Buna ek olarak EXERBRAIN, insan iPSC’den t\u00fcretilen n\u00f6ronlar, astrositler ve mikrogliadaki beyin metabolik de\u011fi\u015fikliklerini taklit ederek, egzersizin beyin metabolizmas\u0131 \u00fczerindeki etkilerini, artan Amiloid-beta \u00fcretimi, hiperfosforile Tau birikimi dahil olmak \u00fczere \u00f6nemli Alzheimer hastal\u0131\u011f\u0131 patolojik ve n\u00f6roinflamasyon s\u00fcre\u00e7lerine ba\u011flayan mekanizmalar\u0131 \u00f6zelikle transkripsiyonel ve epigenomik de\u011fi\u015fiklikleri ortaya \u00e7\u0131karmay\u0131 hedefliyoruz\u201ddiye konu\u015ftu. \u00a0<\/span><\/p>\n

Prof. Dr. \u00c7\u0131\u011f\u0131r Biray Avc\u0131, \u201cEXERBRAIN, egzersizi beyin metabolizmas\u0131na ve Alzheimer patogenezine ba\u011flayan molek\u00fcler yollar\u0131 epigenetik ve transkriptomik yakla\u015f\u0131mlar ile ortaya \u00e7\u0131karacak. B\u00f6ylece Alzheimer i\u00e7in farmakolojik olmayan bir m\u00fcdahale olarak egzersizin koruyucu etkisinin alt\u0131nda yatan mekanizmalar hakk\u0131nda yeni bir anlay\u0131\u015f yaratacak \u201cdedi.<\/span><\/p>\n

Proje ekibinde E\u00dcTF T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Cumhur G\u00fcnd\u00fcz ara\u015ft\u0131rmac\u0131, doktora \u00f6\u011frencileri Maryam Sabour Takanlou ve Leila Sabour Takanlou ise\u00a0 bursiyer olarak g\u00f6rev al\u0131yor.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u201cEXERBRAIN\u201d projesinde Almanya, Hollanda ve \u0130spanya\u2019dan\u00a0 akademisyenler\u00a0 de yer al\u0131yor Egeli akademisyen ve ekibi, Alzheimer…<\/p>\n","protected":false},"author":2,"featured_media":23062,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-23061","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Prof-Dr.-Cigir-Biray-Avci-Prof.-Dr.-Necdet-Budak-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/23061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=23061"}],"version-history":[{"count":2,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/23061\/revisions"}],"predecessor-version":[{"id":23064,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/23061\/revisions\/23064"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/23062"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=23061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=23061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=23061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}