Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi G\u00f6z Hastal\u0131klar\u0131 Anabilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. \u00d6zlem Barut Selver\u2019in\u00a0y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc \u00fcstlendi\u011fi \u201cAmniyon Membran Ekstrakt\u0131n\u0131n Limbal Eksplant K\u00fclt\u00fcrdeki K\u00f6k H\u00fccre Oran\u0131na Etkisinin Transforme Edici B\u00fcy\u00fcme Fakt\u00f6r Beta Resept\u00f6r \u0130nhibisyonu ile Mod\u00fclasyonu\u201d projesi T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) taraf\u0131ndan desteklenmeye uygun bulundu.<\/p>\n
Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak proje y\u00fcr\u00fct\u00fcc\u00fcs\u00fc Do\u00e7. Dr. \u00d6zlem Barut Selver\u2019i makam\u0131nda a\u011f\u0131rlayarak \u00e7al\u0131\u015fmalar\u0131nda ba\u015far\u0131lar diledi. Rekt\u00f6r Prof. Dr. Budak, Ege \u00dcniversitesinin \u00f6zellikle sa\u011fl\u0131k alan\u0131nda \u00f6nemli projelere imza att\u0131\u011f\u0131n\u0131, bu projelerin de ulusal ve uluslararas\u0131 arenada pek \u00e7ok yetkili kurulu\u015f taraf\u0131ndan desteklendi\u011fini vurgulad\u0131.<\/p>\n
Proje hakk\u0131nda bilgi veren Do\u00e7. Dr. \u00d6zlem Barut Selver, \u201cBebek zar\u0131 olarak bilinen insan amniyon membran\u0131 (iAM); yang\u0131 bask\u0131lay\u0131c\u0131 ve yara iyile\u015ftirici \u00f6zellikleri ile t\u0131pta bir\u00e7ok alanda yayg\u0131n kullan\u0131m\u0131 bulunan \u00f6nemli bir dokudur. G\u00f6z Hastal\u0131klar\u0131nda, \u00f6zellikle a\u011f\u0131r kimyasal yan\u0131klar\u0131n tedavisinde ve iyile\u015fmeyen \u00fclserlerde, yara iyile\u015fmesini h\u0131zland\u0131rmak, yang\u0131y\u0131 bask\u0131lamak, enfeksiyonu \u00f6nlemek ve yer kaplay\u0131c\u0131 \u00f6zelli\u011finden faydalanmak amac\u0131yla uygulanan iAM, s\u0131kl\u0131kla kriyoprezervasyonla haz\u0131rland\u0131ktan sonra \u2018amniyon membran nakli\u2019 \u015feklinde kullan\u0131lmaktad\u0131r. Bu kullan\u0131m \u015feklinin, cerrahi gerektirmesi, istenilen s\u00fcre kadar kullan\u0131lamamas\u0131 ve yar\u0131 opak yap\u0131s\u0131 nedeniyle objektif klinik g\u00f6zlemin yap\u0131lamamas\u0131 gibi k\u0131s\u0131tl\u0131l\u0131klar\u0131 bulunmaktad\u0131r. Bu k\u0131s\u0131tl\u0131l\u0131klar\u0131 azaltmak ad\u0131na, amniyon membran ekstrakt\u0131n\u0131n (AME) haz\u0131rlanmas\u0131, uygun saklama ko\u015fullar\u0131n\u0131n sa\u011flanmas\u0131 amac\u0131yla liyofilize edilmesi ve buradan hareketle oftalmik \u00e7\u00f6zeltisinin haz\u0131rlanarak klinik pratikte uygulanmas\u0131 fikri do\u011fmu\u015ftur. AME formu kullan\u0131m\u0131n\u0131n en b\u00fcy\u00fck avantaj\u0131, cerrahi giri\u015fim gerektirmemesi, tedavi s\u00fcresince ok\u00fcler y\u00fczeyin objektif klinik g\u00f6zleminin yap\u0131labilmesi, uygulama s\u00fcresi boyunca y\u00fcksek ve sabit miktarda b\u00fcy\u00fcme fakt\u00f6r\u00fc deste\u011fi sa\u011flayabilmesi ve uzun bir raf \u00f6mr\u00fcne sahip olabilme potansiyelidir. G\u00f6rme fonksiyonunun iyi olabilmesi i\u00e7in, g\u00f6z y\u00fczeyinde bulunan saydam doku olan kornean\u0131n sa\u011fl\u0131kl\u0131 olmas\u0131 gerekmektedir. G\u00f6z y\u00fczeyi k\u00f6k h\u00fccreleri kornean\u0131n yenilenerek sa\u011fl\u0131kl\u0131 kalmas\u0131ndan sorumludur. Kimyasal yan\u0131klar gibi durumlarla bu k\u00f6k h\u00fccrelerin hasarlanmas\u0131, k\u00f6k h\u00fccre yetmezli\u011fi ile geli\u015fen k\u00f6rl\u00fckle sonu\u00e7lanabilir. B\u00f6ylesi bir problemde kaybedilen k\u00f6k h\u00fccrelerin yerine konmas\u0131 kritik \u00f6nem ta\u015f\u0131r. Laboratuvarda bu k\u00f6k h\u00fccrelerin \u00e7o\u011falt\u0131lmas\u0131 ile ilgili t\u00fcm d\u00fcnyada uzun y\u0131llard\u0131r \u00e7al\u0131\u015fmalar s\u00fcrmektedir\u201d dedi.<\/p>\n
\u201c5 y\u0131ld\u0131r aktif olarak AME ile ilgili \u00e7al\u0131\u015fmaktay\u0131z\u201d<\/b><\/p>\n
Do\u00e7. Dr. Barut Selver, \u201cG\u00f6z y\u00fczey k\u00f6k h\u00fccreleri ile ilgili olarak 20 y\u0131ld\u0131r, AME ile ilgili olarak ise 5 y\u0131ld\u0131r aktif olarak \u00e7al\u0131\u015fmaktay\u0131z. Bu konular ile ilgili bir\u00e7ok T\u00dcB\u0130TAK ve T\u00dcSEB da d\u00e2hil olmak \u00fczere ulusal ve uluslararas\u0131 proje tamamlad\u0131k. \u00c7al\u0131\u015fmalar\u0131m\u0131za 2021 y\u0131l\u0131nda Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi i\u00e7inde kurdu\u011fumuz Ok\u00fcler Y\u00fczey Ara\u015ft\u0131rma Laboratuvar\u0131nda devam etmekteyiz. Bug\u00fcne kadar yapm\u0131\u015f oldu\u011fumuz \u00e7al\u0131\u015fmalarla gelmi\u015f oldu\u011fumuz noktada ise, AME i\u00e7eri\u011finde di\u011fer b\u00fcy\u00fcme fakt\u00f6rlerine g\u00f6re daha y\u00fcksek miktarda Transforme edici b\u00fcy\u00fcme fakt\u00f6r\u00fc beta (TGF\u03b2) bulundu\u011funu g\u00f6zlemledik. \u00a0T\u00dcSEB projemiz ile ortamdaki TGF\u03b2 resept\u00f6r inhibisyonunun, ok\u00fcler y\u00fczey k\u00f6k h\u00fccre k\u00fclt\u00fcr\u00fcnde, destekleyici olarak ilave edilen ve y\u00fcksek miktarda TGF\u03b2 i\u00e7eren AME\u2019nin k\u00f6k h\u00fccre art\u0131\u015f\u0131 sa\u011flama etkisine mod\u00fclasyonunu tan\u0131mlayaca\u011f\u0131z\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi G\u00f6z Hastal\u0131klar\u0131 Anabilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. \u00d6zlem Barut Selver\u2019in\u00a0y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc…<\/p>\n","protected":false},"author":2,"featured_media":22992,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-22991","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/08\/Doc.Dr_.Ozlem-Barut-Selver-Prof.-Dr.-Necdet-Budak-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/22991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=22991"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/22991\/revisions"}],"predecessor-version":[{"id":22993,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/22991\/revisions\/22993"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/22992"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=22991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=22991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=22991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}