Ege \u00dcniversitesi (E\u00dc) T\u0131p Fak\u00fcltesi Parazitoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Ay\u015fe Caner\u2019in y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cKanser Hastalar\u0131n\u0131n Tedavisinde KRAS’\u0131 Hedefleyen Molek\u00fcller\u201d ba\u015fl\u0131kl\u0131 proje T\u00dcSEB-KD\/Klinik D\u0131\u015f\u0131 \u00c7al\u0131\u015fmalara Y\u00f6nelik Proje \u00c7a\u011fr\u0131s\u0131 kapsam\u0131nda desteklenmeye uygun bulundu. Houston Weill Cornell T\u0131p Fak\u00fcltesi, Methodist Ara\u015ft\u0131rma Enstit\u00fcs\u00fc Nanot\u0131p B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00fcyesi Prof. Dr. B\u00fclent \u00d6zpolat, Ankara \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Emekli \u00d6\u011fretim \u00dcyesi Prof. Dr. Erdem B\u00fcy\u00fckbing\u00f6l ve Marmara \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi \u00d6\u011fretim \u00dcyesi Dr. Asl\u0131 T\u00fcre\u2019nin proje orta\u011f\u0131 olarak yer ald\u0131\u011f\u0131 \u00e7al\u0131\u015fma ile kanser tedavisinde KRAS onkojen genine y\u00f6nelik ila\u00e7 geli\u015ftirilmesi hedefleniyor.<\/p>\n
Prof. Dr. Ay\u015fe Caner\u2019i makam\u0131nda a\u011f\u0131rlayan Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201cEge \u00dcniversitesi akademisyenlerimiz son y\u0131llarda kanser hastal\u0131\u011f\u0131 ba\u015fta olmak \u00fczere yerli ve milli ila\u00e7 \u00fcretme konusunda nitelikli projeler ger\u00e7ekle\u015ftirmeye devam ediyor. TUSEB-KD\/Klinik D\u0131\u015f\u0131 \u00c7al\u0131\u015fmalara Y\u00f6nelik Proje \u00c7a\u011fr\u0131s\u0131 kapsam\u0131nda y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Prof. Dr. Ay\u015fe Caner hocam\u0131z\u0131n \u00fcstlendi\u011fi bu \u00f6nemli projenin, \u00e7a\u011f\u0131m\u0131z\u0131n en \u00f6nemli hastal\u0131\u011f\u0131 olan kanserin tedavisinde ve \u00fclkemizde milli ila\u00e7 \u00fcretimine y\u00f6nelik \u00e7al\u0131\u015fmalara \u00f6nemli katk\u0131 sa\u011flayaca\u011f\u0131n\u0131 d\u00fc\u015f\u00fcn\u00fcyorum\u201d dedi.<\/p>\n
Proje hakk\u0131nda bilgi veren Prof. Dr. Caner, \u201cKRAS onkojen geni, insan kanserlerinde en \u00e7ok g\u00f6r\u00fclen mutasyonlardan birisi ve normal h\u00fccrelerin kanser h\u00fccrelerine ve t\u00fcm\u00f6ral bir yap\u0131ya d\u00f6n\u00fc\u015fmesine yol a\u00e7\u0131yor. Bu nedenle, KRAS insan kanserlerindeki en \u00f6nemli hedeflerden birisi olarak kar\u015f\u0131m\u0131za \u00e7\u0131k\u0131yor. G\u00fcn\u00fcm\u00fczde, gerek ila\u00e7 sekt\u00f6r\u00fcn\u00fcn ve gerekse akademik ara\u015ft\u0131rmalar\u0131n b\u00fct\u00fcn \u00e7abalar\u0131na ra\u011fmen, d\u00fcnyada hen\u00fcz hastalarda klinik denemelerde ba\u015far\u0131l\u0131 olan ve FDA onay\u0131 alan bir KRAS inhibitor molek\u00fcl\u00fc bulunmuyor\u201d diye konu\u015ftu.<\/p>\n
\u201cGeli\u015ftirdi\u011fimiz molek\u00fcl, klinik \u00e7al\u0131\u015fmalara olanak sa\u011flayacak\u201d<\/b><\/p>\n
Prof. Dr. Caner, \u201cAra\u015ft\u0131rma grubumuzun tasarlay\u0131p, sentezini yapt\u0131\u011f\u0131 bir\u00e7ok molek\u00fcl MD Anderson Kanser Merkezi\u2019nde \u2018in vitro\u2019 ve \u2018in vivo\u2019 d\u00fczeyde test edildi\u011finde, i\u00e7lerinde bir molek\u00fcl aktif inhibit\u00f6r oldu\u011fu g\u00f6r\u00fcld\u00fc. Bu inhibit\u00f6r molek\u00fcl\u00fcn\u00fcn, kanser h\u00fccrelerinde ve hayvan modellerinde t\u00fcm\u00f6ral olu\u015fumu durdurdu\u011fu daha da \u00f6nemlisi, bu geli\u015ftirilen molek\u00fcl, Amerika Birle\u015fik Devletlerinde klinik \u00e7al\u0131\u015fmalar a\u015famas\u0131na giren ve KRAS protein inhibit\u00f6r\u00fc olan salirasib\u2019ten daha potent oldu\u011fu anla\u015f\u0131lm\u0131\u015ft\u0131r. Bu nedenle, 3E molek\u00fcl\u00fc klinik \u00e7al\u0131\u015fmalar\u0131n ger\u00e7ekle\u015fmesine olanak sa\u011flayacak bir \u00f6zelli\u011fe sahip\u201d dedi.<\/p>\n
Y\u00fcr\u00fct\u00fclen i\u015fbirli\u011fi projesinin \u00f6nemine de\u011finen Prof. Dr. Caner, \u201cT\u00dcSEB ile i\u015fbirli\u011fi projesi, T\u00fcrkiye\u2019de milli ila\u00e7 kapsam\u0131nda ila\u00e7 molek\u00fcl\u00fc ke\u015ffine y\u00f6nelik klinik a\u015famalar\u0131 desteklemek i\u00e7in ortaya konulmu\u015f \u00e7ok \u00f6nemli bir ara\u015ft\u0131rmad\u0131r. Y\u00fcr\u00fctt\u00fc\u011f\u00fcm\u00fcz bu proje sayesinde, KRAS inhibit\u00f6r\u00fcn\u00fcn toksisite \u00e7al\u0131\u015fmalar\u0131 ger\u00e7ekle\u015ftirilecek, sonras\u0131nda klinik \u00e7al\u0131\u015fmalar ile y\u00fcr\u00fcyebilecek d\u00fczeyde ele al\u0131nmas\u0131n\u0131 sa\u011flanacakt\u0131r\u201d diye konu\u015ftu..<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi (E\u00dc) T\u0131p Fak\u00fcltesi Parazitoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Ay\u015fe Caner\u2019in y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc…<\/p>\n","protected":false},"author":2,"featured_media":22235,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[99,1,70,68],"tags":[],"class_list":["post-22234","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner.jpg",1407,961,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner-300x205.jpg",300,205,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner-768x525.jpg",640,438,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner-1024x699.jpg",640,437,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner.jpg",1407,961,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner.jpg",1407,961,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner-1024x699.jpg",1024,699,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/06\/Prof.-Dr.-Necdet-Budak-Prof.Dr_.Ayse-Caner-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/22234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=22234"}],"version-history":[{"count":2,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/22234\/revisions"}],"predecessor-version":[{"id":22237,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/22234\/revisions\/22237"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/22235"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=22234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=22234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=22234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}