\u00a0Egeli multidisipliner bilim ekibinin Ar-Ge projesine T\u00dcB\u0130TAK-TAGEM\u2019den destek<\/p>\n
\u00a0<\/b>Zeytinya\u011f\u0131 at\u0131klar\u0131 omurilik yaralanmalar\u0131nda g\u0131da takviyesi olarak kullan\u0131lacak<\/b><\/p>\n
Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi Ortopedi ve Travmatoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Murat Celal S\u00f6zbilen\u2019in y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131\u00a0 \u201cZeytinya\u011f\u0131 \u00dcretim S\u00fcreci At\u0131klar\u0131n\u0131n Omurilik Yaralanmas\u0131 Modelinde G\u0131da Takviyesi ve\/veya Tedavi Ajan\u0131 Olarak De\u011ferlendirilmesi\u201d ba\u015fl\u0131kl\u0131 proje, T\u00dcB\u0130TAK-TAGEM i\u015fbirli\u011fi \u00e7er\u00e7evesinde 1005-Ulusal Yeni Fikirler ve \u00dcr\u00fcnler Ara\u015ft\u0131rma Destek Program\u0131 alt\u0131nda desteklenmeye hak kazand\u0131.<\/p>\n
Proje ekibini makam\u0131nda a\u011f\u0131rlayarak tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201cTam akredite, \u00f6\u011frenci odakl\u0131 ara\u015ft\u0131rma \u00fcniversitemiz bilim insanlar\u0131, farkl\u0131 kurumlardan ara\u015ft\u0131rmac\u0131larla i\u015f birli\u011fi yaparak, disiplinleraras\u0131 projeler \u00fcretmeye devam ediyorlar. Ara\u015ft\u0131rmac\u0131lar\u0131m\u0131z, zeytinya\u011f\u0131 \u00fcretim s\u00fcrecinde at\u0131k olarak ortaya \u00e7\u0131kan yaprak ve pirina at\u0131klar\u0131ndan fenolik bile\u015fenlerce zengin ekstreler elde ederek, \u00a0bu ekstreleri omurilik yaralanmas\u0131nda ferroptoz yola\u011f\u0131 \u00fczerinden de\u011ferlendirecek. Multidisipliner bir anlay\u0131\u015fla haz\u0131rlanan ve T\u00dcB\u0130TAK-TAGEM Ulusal Yeni Fikirler ve \u00dcr\u00fcnler Ara\u015ft\u0131rma Destek Program\u0131 kapsam\u0131nda desteklenmeye uygun bulunan proje Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi Ortopedi ve Travmatoloji Anabilim Dal\u0131, Eczac\u0131l\u0131k Fak\u00fcltesi, EGEMATAL ve TAGEM b\u00fcnyesindeki Zeytincilik Ara\u015ft\u0131rma Enstit\u00fcs\u00fc ile birlikte y\u00fcr\u00fct\u00fclecek. Proje ekibini tebrik ediyor, ba\u015far\u0131lar\u0131n\u0131n devam\u0131n\u0131 diliyorum\u201d dedi.<\/p>\n
\u201cZeytinya\u011f\u0131 at\u0131klar\u0131n\u0131n sa\u011fl\u0131k alan\u0131nda kullan\u0131lmas\u0131 \u00e7ok \u00f6nemli\u201d<\/b><\/p>\n
Ara\u015ft\u0131rman\u0131n i\u00e7eri\u011fi ile ilgili bilgi proje y\u00fcr\u00fct\u00fcc\u00fcs\u00fc Do\u00e7. Dr. Murat Celal S\u00f6zbilen, \u201cZeytinya\u011f\u0131 end\u00fcstrisinde, \u00fcretim s\u00fcrecinde pirina, karasu, zeytin yapraklar\u0131 gibi at\u0131klar ortaya \u00e7\u0131kmaktad\u0131r. \u00dclkemizin bu alandaki zengin kaynaklar\u0131 g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda at\u0131k \u00fcr\u00fcnlerin de\u011ferlendirilmesi, \u00f6zellikle sa\u011fl\u0131k alan\u0131nda kullan\u0131labilmesi \u00e7oklu fayday\u0131 beraberinde getirecektir. Omurilik yaralanmalar\u0131 d\u00fcnyada yakla\u015f\u0131k iki milyon ki\u015fiyi etkilemektedir. Omurilik yaralanmas\u0131, primer ve sekonder hasara sebep olur. Sekonder hasar, yaralanmay\u0131 takiben birka\u00e7 saat i\u00e7inde g\u00f6r\u00fcl\u00fcr; n\u00f6ronal \u00f6l\u00fcm, inflamasyon ve hemoliz gibi s\u00fcre\u00e7leri kapsar. N\u00f6ronal \u00f6l\u00fcmde ferroptoz yola\u011f\u0131n\u0131n rol\u00fc g\u00f6sterilmi\u015ftir. Dolay\u0131s\u0131yla ferroptozun inhibisyonu ile hasar b\u00f6lgesinde beklenen h\u00fccre \u00f6l\u00fcm\u00fcn\u00fcn \u00f6n\u00fcne ge\u00e7mek umut vadeden bir stratejidir\u201d dedi.<\/p>\n
\u201cFenolik i\u00e7erikli ekstreler g\u0131da takviyesine d\u00f6n\u00fc\u015ft\u00fcr\u00fclecek\u201d<\/b><\/p>\n
Projenin amac\u0131ndan bahseden Do\u00e7. Dr. Murat Celal S\u00f6zbilen, \u201cProjemizde \u00f6ncelikle zeytinya\u011f\u0131 \u00fcretim s\u00fcrecinde ortaya \u00e7\u0131kan at\u0131klar\u0131n i\u00e7erdi\u011fi antioksidan etkili fenolik bile\u015fenler g\u00f6z \u00f6n\u00fcne al\u0131narak, farkl\u0131 zeytin \u00e7e\u015fitlerinin yapraklar\u0131 ve pirinadan fenolik\u00e7e zengin ekstreler elde edilecektir. Bu ekstrelerin i\u00e7erdi\u011fi fenolik bile\u015fenler LC\/QTOF\/MS y\u00f6ntemiyle taranarak tespit edilecek ve sonras\u0131nda h\u00fccre k\u00fclt\u00fcr\u00fc ile potansiyeli en y\u00fcksek ekstreler belirlenecektir. Belirlenen ekstreler kullan\u0131larak hem fenolik bile\u015fenlerce zengin diyetle beslenen hem de beslenmeyen omurilik yaralanma modeli uygulanm\u0131\u015f deney hayvanlar\u0131 \u00fczerinde \u00e7al\u0131\u015f\u0131lacak ve fenolik ekstrelerin sinir h\u00fccrelerini iyile\u015ftirme ve sinir hasar\u0131n\u0131 en aza indirme etkileri de\u011ferlendirilecektir. B\u00f6ylece \u00fclkemizin bitki \u00f6rt\u00fcs\u00fcnde \u00e7ok\u00e7a bulunan zeytinin \u00fcretim at\u0131klar\u0131ndan elde edilecek zengin fenolik i\u00e7eri\u011fe sahip ekstrelerin g\u0131da takviyesi ve farmas\u00f6tik \u00fcr\u00fcne d\u00f6n\u00fc\u015fmesini hedeflenmektedir\u201d diye konu\u015ftu.<\/p>\n
\u00a0\u201cG\u0131da takviyesi \u00fcr\u00fcnlerinde katma de\u011fer \u00fcreterek d\u0131\u015fa ba\u011fl\u0131l\u0131\u011f\u0131 azaltacak\u201d<\/b><\/p>\n
Do\u00e7. Dr. Murat Celal S\u00f6zbilen, \u201cS\u00fcrd\u00fcr\u00fclebilir Kalk\u0131nma hedeflerinden biri \u2018at\u0131k\u2019 kavram\u0131n\u0131n \u00e7\u00f6pten ziyade \u2018kaynak\u2019 olarak benimsenmesidir. Projemiz, zeytinya\u011f\u0131 \u00fcretim at\u0131klar\u0131n\u0131n ve zeytin yapraklar\u0131ndan elde edilen zengin fenolik i\u00e7eri\u011fe sahip ekstrelerin g\u0131da takviyesi ve farmas\u00f6tik \u00fcr\u00fcne d\u00f6n\u00fc\u015fmesini hedefleyen \u00f6zg\u00fcn bir ara\u015ft\u0131rmad\u0131r. G\u0131da takviyelerinin kullan\u0131m\u0131 \u00fclkemizde ciddi oranda art\u0131\u015f g\u00f6stermekte; yerli \u00fcretimin s\u0131n\u0131rl\u0131 olmas\u0131ndan kaynaklanan d\u0131\u015fa ba\u011f\u0131ml\u0131l\u0131k \u00fclke ekonomisini olumsuz etkilemektedir. Proje sonunda, etkinli\u011fi ve i\u00e7eri\u011fi tespit edilecek ekstre, g\u0131da takviyesi olarak de\u011ferlendirilebilecek; se\u00e7ilen biyoaktif ekstre ve standart madde daha ileri tedavi etkinlik \u00e7al\u0131\u015fmalar\u0131 tamamlanarak yerli ila\u00e7 end\u00fcstrisine geli\u015ftirilebilir \u00fcr\u00fcnler olarak sunulabilecek ve elde edilecek veriler bu alanda yap\u0131lacak Ar-Ge ve yat\u0131r\u0131m projelerine \u0131\u015f\u0131k tutacakt\u0131r. B\u00f6ylece \u00fclkemizin biyolojik zenginli\u011fi olan ve \u00fcretim g\u00fcc\u00fcne sahip oldu\u011fumuz zeytin bitkisinden farkl\u0131 alanlarda kullan\u0131labilecek, katma de\u011feri y\u00fcksek \u00fcr\u00fcnler elde edilebilecektir. Proje \u00e7\u0131kt\u0131lar\u0131n\u0131n, k\u0131sa ve uzun vadede ekonomik ve toplumsal faydaya d\u00f6n\u00fc\u015fece\u011fi a\u00e7\u0131kt\u0131r\u201d dedi.<\/p>\n
Disiplinleraras\u0131 bilim ekibi<\/b><\/p>\n
Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi Ortopedi ve Travmatoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Murat Celal S\u00f6zbilen\u2019 in y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 projenin ekibinde Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim \u00fcyeleri Prof. Dr. Buket Bozkurt ve Prof. Dr. G\u00fcliz Arma\u011fan ile Zeytincilik Ara\u015ft\u0131rma Enstit\u00fcs\u00fcnden Dr. G\u00f6zde S\u00f6zbilen, EGEMATAL\u2019dan Dr. Zinar P\u0131nar G\u00fcm\u00fc\u015f yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"
\u00a0Egeli multidisipliner bilim ekibinin Ar-Ge projesine T\u00dcB\u0130TAK-TAGEM\u2019den destek \u00a0Zeytinya\u011f\u0131 at\u0131klar\u0131 omurilik yaralanmalar\u0131nda g\u0131da takviyesi olarak…<\/p>\n","protected":false},"author":2,"featured_media":19664,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-19663","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2024\/02\/ProfDr-Necdet-Budak_Doc.Dr-Murat-Celal-Sozbilen_Buket-Bozkurt_Dr.-Zinar-Pinar-Gumus_Dr-Gozde-Sozbilen-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/19663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=19663"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/19663\/revisions"}],"predecessor-version":[{"id":19665,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/19663\/revisions\/19665"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/19664"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=19663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=19663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=19663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}