Ege \u00dcniversitesi (E\u00dc) Fen Fak\u00fcltesi Biyokimya B\u00f6l\u00fcm\u00fcnde \u00e7al\u0131\u015fmalar\u0131n\u0131 s\u00fcrd\u00fcren Prof. Dr. Sinan Akg\u00f6l ve Do\u00e7. Dr. Kevser Ku\u015fat\u2019\u0131n \u201cHipertansiyon Tedavisinde Amlodipinin Kontroll\u00fc Sal\u0131m\u0131 \u0130\u00e7in Polimerik Nanomalzeme\u201d konulu bulu\u015fu Sanayi ve Teknoloji Bakanl\u0131\u011f\u0131 T\u00fcrk Patent ve Marka Kurumu taraf\u0131ndan tescil belgesini almaya hak kazand\u0131. Bulu\u015f sayesinde geli\u015ftirilen nanopolimerler, hipertansiyon tedavisine y\u00f6nelik t\u0131p, nanoteknoloji ve farmakoloji alan\u0131nda kullan\u0131m alan\u0131 bulabilecek ve\u00a0antihipertansif ila\u00e7larla ili\u015fkili istenmeyen yan etkileri en aza indirgenebilecek.<\/p>\n
Prof. Dr. Akg\u00f6l ve Do\u00e7. Dr. Ku\u015fat\u2019\u0131 makam\u0131nda a\u011f\u0131rlayan Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak,\u00a0 \u201cHem e\u011fitim hem de Ar-Ge faaliyetlerinde kalitesi tescillenmi\u015f bir ara\u015ft\u0131rma kurumu olan \u00fcniversitemiz b\u00fcnyesindeki yetkin akademisyenlerimiz bilim d\u00fcnyas\u0131na \u00f6nemli katk\u0131lar sunmaya devam ediyor.\u00a0 Bilim insanlar\u0131m\u0131z taraf\u0131ndan y\u00fcr\u00fct\u00fclen projeler \u00fcr\u00fcne d\u00f6n\u00fc\u015f\u00fcp,\u00a0 hem \u00fclkemizde hem de uluslararas\u0131 arenada tescil edilerek, insanl\u0131\u011f\u0131n ve bilimin hizmetine sunuluyor. De\u011ferli hocalar\u0131m\u0131z Prof. Dr. Akg\u00f6l ve Do\u00e7. Dr. Ku\u015fat\u2019\u0131n \u00fcr\u00fcn olma potansiyeli y\u00fcksek bu \u00e7al\u0131\u015fmalar\u0131na ait patent ba\u015fvurular\u0131n\u0131n tescillenmesi bizleri ziyadesiyle mutlu k\u0131ld\u0131.\u00a0 \u00a0Nanobiyoteknoloji ile \u00fcretilmi\u015f olan nanopolimerler, t\u0131p, nanoteknoloji ve farmakoloji alan\u0131nda hipertansiyonun tedavisinde kullan\u0131labilecek. Her iki hocam\u0131z\u0131 bilime, teknolojiye ve toplum sa\u011fl\u0131\u011f\u0131na fayda sa\u011flayan bu bulu\u015flar\u0131 i\u00e7in tebrik ediyor, \u00fclkemiz \u00fcretimine yapt\u0131klar\u0131 katk\u0131lar i\u00e7in te\u015fekk\u00fcrlerimi sunuyorum\u201d dedi.<\/p>\n
\u201cYan etkilerin azalt\u0131lmas\u0131 sa\u011flanacak\u201d<\/b><\/p>\n
Hipertansiyon tedavisinde daha geli\u015fmi\u015f kontroll\u00fc sal\u0131m sistemlerine ihtiya\u00e7 duyuldu\u011funu belirten Prof. Dr. Akg\u00f6l, \u201cAntihipertansif ila\u00e7lar hipertansiyonu kontrol etmek i\u00e7in farkl\u0131 biyokimyasal mekanizmalar\u0131 kullanmaktad\u0131r. Hemen hemen t\u00fcm bu ila\u00e7lar\u0131n oral tablet formlar\u0131 mevcuttur. Ancak, ila\u00e7lar\u0131n y\u00fczde 80\u2019in alt\u0131nda d\u00fc\u015f\u00fck oral biyoyararlan\u0131m\u0131 vard\u0131r. Valsartan, amlodipin ve benzeri ila\u00e7lar\u0131n oral biyoyararlan\u0131m\u0131, \u00e7ok d\u00fc\u015f\u00fck ve bazen d\u00fczensizdir. Bu y\u00fczden, daha geli\u015fmi\u015f kontroll\u00fc sal\u0131m sistemlerine ihtiya\u00e7 duyulmakta; doz aral\u0131\u011f\u0131n\u0131 azaltmak, biyoyararlan\u0131m\u0131 art\u0131rmak ve istenmeyen yan etkilerin azalt\u0131lmas\u0131 i\u00e7in bu sistemler gereklidir. Nanoila\u00e7lar ilac\u0131n biyoyararlan\u0131m, emilimi ve tutma s\u00fcresini art\u0131racak; sonu\u00e7 olarak minimal ila\u00e7 dozu ile istenen etki sa\u011flan\u0131p ila\u00e7 al\u0131m s\u0131kl\u0131\u011f\u0131 azalt\u0131labilir, ilaca ba\u011fl\u0131 istenmeyen yan etkileri bertaraf edilebilir. Geli\u015ftirdi\u011fimiz hipertansiyon tedavisinde kullan\u0131lan Amlodipin (AML) y\u00fckl\u00fc polimerik nanopolimer ile oral uygulamalarda kontroll\u00fc sal\u0131m olana\u011f\u0131 sa\u011flanmakta ve oral biyoyararlan\u0131m\u0131n\u0131 artt\u0131rarak, plazma yar\u0131 \u00f6mr\u00fcn\u00fc art\u0131rma ve dozaj gereksinimlerini ve al\u0131m s\u0131kl\u0131\u011f\u0131n\u0131 azaltarak antihipertansif ila\u00e7larla ili\u015fkili istenmeyen yan etkileri en aza indirgeyebilmektedir\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi (E\u00dc) Fen Fak\u00fcltesi Biyokimya B\u00f6l\u00fcm\u00fcnde \u00e7al\u0131\u015fmalar\u0131n\u0131 s\u00fcrd\u00fcren Prof. Dr. Sinan Akg\u00f6l ve Do\u00e7….<\/p>\n","protected":false},"author":2,"featured_media":18595,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70],"tags":[],"class_list":["post-18594","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak.jpg",2448,1892,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak-300x232.jpg",300,232,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak-768x594.jpg",640,495,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak-1024x791.jpg",640,494,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak-1536x1187.jpg",1536,1187,true],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak-2048x1583.jpg",2048,1583,true],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak-1024x791.jpg",1024,791,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/12\/Prof.-Dr.-Sinan-Akgol-Prof.-Dr.-Necdet-Budak-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a>","tag_info":"Kamp\u00fcs","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/18594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=18594"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/18594\/revisions"}],"predecessor-version":[{"id":18596,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/18594\/revisions\/18596"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/18595"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=18594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=18594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=18594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}