{"id":1832,"date":"2021-01-14T07:37:23","date_gmt":"2021-01-14T07:37:23","guid":{"rendered":"http:\/\/www.euegeajans.com\/?p=1832"},"modified":"2026-03-13T09:18:37","modified_gmt":"2026-03-13T09:18:37","slug":"egeli-bilim-ekibinden-koronaviruslerin-genetik-sifrelerini-cozen-arastirma","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2021\/01\/14\/egeli-bilim-ekibinden-koronaviruslerin-genetik-sifrelerini-cozen-arastirma\/","title":{"rendered":"Egeli bilim ekibinden koronavir\u00fcslerin genetik \u015fifrelerini \u00e7\u00f6zen ara\u015ft\u0131rma"},"content":{"rendered":"

Prof. Dr. \u00dcn\u2019\u00fcn koronavir\u00fcs i\u00e7in a\u015f\u0131 geli\u015ftirme konusunda yapt\u0131\u011f\u0131 \u00e7al\u0131\u015fma Nature \u0130ndeks\u2019te yay\u0131mland\u0131<\/p>\n

\u0130ZM\u0130R(Ege Ajans)-<\/b>\u00a0Ege \u00dcniversitesinden bir grup bilim insan\u0131 farkl\u0131 \u00fclkelerde g\u00f6r\u00fclen coronavir\u00fcslerin (SARS-CoV-2) genetik dizilimlerini bilgisayar tabanl\u0131 y\u00f6ntemlerle tarayarak \u015fifrelerini analiz etti.\u00a0 Vir\u00fcs\u00fcn yap\u0131s\u0131nda bulunan 27 proteinin a\u015f\u0131 olarak kullan\u0131labilme potansiyelini hesaplayan bilim ekibi,\u00a0 s\u0131ralama yaparak en ideal a\u015f\u0131 aday\u0131n\u0131 belirledi.<\/p>\n

Genom ve biyoinformatik konular\u0131 \u00fczerine ara\u015ft\u0131rmalar yapan Ege \u00dcniversitesi Fen Fak\u00fcltesi Biyoloji B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Prof. Dr. Cemal \u00dcn\u2019\u00fcn y\u00f6ntemindeki bir grup ara\u015ft\u0131rmac\u0131n\u0131n koronavir\u00fcs i\u00e7in a\u015f\u0131 geli\u015ftirme konusunda yapt\u0131\u011f\u0131 \u00e7al\u0131\u015fma Nature \u0130ndeks\u2019te yay\u0131mland\u0131. D\u00fcnyay\u0131 etkisi alt\u0131na alan ve t\u00fcm insanl\u0131\u011f\u0131 ilgilendiren g\u00fcncel bir konudan nitelikli bir ara\u015ft\u0131rmaya imza atan Prof. Dr. Cemal \u00dcn\u2019\u00fc ve ara\u015ft\u0131rma ekibini tebrik eden E\u00dc Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, ara\u015ft\u0131rman\u0131n etki de\u011feri y\u00fcksek bilimsel bir dergide yay\u0131mlanmas\u0131ndan duydu\u011fu memnuniyeti dile getirdi.<\/p>\n

\u00c7al\u0131\u015fma ile ilgili bilgi veren Prof. Dr. Cemal \u00dcn, \u201cKoronavir\u00fcs i\u00e7in a\u015f\u0131 geli\u015ftirme konusunda yapt\u0131\u011f\u0131m\u0131z ara\u015ft\u0131rma, etki de\u011feri y\u00fcksek en \u00e7ok at\u0131f alan dergiler s\u0131ralamas\u0131nda binlerce dergi aras\u0131ndan 6\u2019nc\u0131 s\u0131rada yer alan Nature yay\u0131n grubuna ait derginin Aral\u0131k say\u0131s\u0131nda yay\u0131mland\u0131. Ara\u015ft\u0131rma ekibi olarak \u00a0koronavir\u00fcs\u00fcn Mart ay\u0131nda T\u00fcrkiye\u2019de ilk kez saptanmas\u0131n\u0131n ard\u0131ndan\u00a0 \u00a0\u00e7al\u0131\u015fmalara ba\u015flad\u0131k.\u00a0 K\u0131sa s\u00fcrede ara\u015ft\u0131rmam\u0131z\u0131 tamamlayarak sonu\u00e7lar\u0131n\u0131 Nisan ay\u0131nda dergiye g\u00f6nderdik.\u00a0 Derginin kalite konusundaki titizli\u011finden dolay\u0131 \u00e7al\u0131\u015fmam\u0131z\u0131n yay\u0131mlanmas\u0131 ancak Aral\u0131k ay\u0131n\u0131n sonunda ger\u00e7ekle\u015fti\u201d dedi.<\/p>\n

Koronavir\u00fcslerin farkl\u0131 \u00fclkelerdeki genetik dizilimini tarad\u0131lar<\/b><\/p>\n

Ara\u015ft\u0131rmay\u0131 ger\u00e7ekle\u015ftirmek i\u00e7in Nisan ay\u0131 itibariyle d\u00fcnyan\u0131n de\u011fi\u015fik\"\" \u00fclkelerinde g\u00f6r\u00fclen t\u00fcm koronavir\u00fcslerin (SARS-CoV-2) genetik dizilimlerini tarad\u0131klar\u0131n\u0131 ifade eden Prof. Dr. \u00dcn, \u201cHer bir vir\u00fcs 30 bin civar\u0131nda genetik harf taraf\u0131ndan \u015fifreleniyor. Vir\u00fcs\u00fcn genetik \u015fifreleri 27 farkl\u0131 proteinin \u00fcretimini ger\u00e7ekle\u015ftiriyor. Bu farkl\u0131 27 protein vir\u00fcs\u00fcn insan h\u00fccrelerine ba\u011flanmas\u0131n\u0131, kendi genetik \u015fifrelerini insan h\u00fccresine aktarmas\u0131n\u0131 ve daha sonra burada \u00e7o\u011falmas\u0131n\u0131 kontrol eden proteinlerden olu\u015fmaktad\u0131r. Proteinleri \u015fifreleyen genetik yap\u0131 i\u00e7erisindeki her hangi bir de\u011fi\u015fim, proteinlerin yap\u0131s\u0131n\u0131n da de\u011fi\u015fmesi anlam\u0131na geliyor. Bu durumda de\u011fi\u015fim etkisiz olabilece\u011fi gibi, vir\u00fcs\u00fcn daha h\u0131zl\u0131 yay\u0131lmas\u0131 ya da insan h\u00fccrelerini daha fazla etkilemesi anlam\u0131na da gelebilir. Bu t\u00fcr genetik de\u011fi\u015fimlerin vir\u00fcs\u00fcn yay\u0131lmas\u0131 ve olabilecek etkilerini, bilgisayar tabanl\u0131 genetik y\u00f6ntemler uygulayarak y\u00fcksek derecede tahmin ettik.\u00a0 Vir\u00fcs\u00fcn yap\u0131s\u0131nda bulunan 27 proteinin analizini bilgisayar tabanl\u0131 genetik analizlerle a\u015f\u0131 olarak kullan\u0131labilme potansiyelini hesaplayarak bir s\u0131ralama yapt\u0131k ve bunlar aras\u0131nda en ideal a\u015f\u0131 aday\u0131n\u0131 belirledik. \u00c7al\u0131\u015fmada a\u015f\u0131 aday\u0131 olarak se\u00e7ilen proteinin d\u00fcnyan\u0131n de\u011fi\u015fik \u00fclkelerinde g\u00f6r\u00fclm\u00fc\u015f olan t\u00fcm koronavir\u00fcsler \u00fczerine etkili olmas\u0131 i\u00e7in de gerekli hesaplamalar yap\u0131ld\u0131\u201d dedi.<\/p>\n

Multidisipliner ara\u015ft\u0131rma ekibi<\/b><\/p>\n

Ara\u015ft\u0131rma ekibinde Prof. Dr. Cemal \u00dcn\u2019\u00fcn yan\u0131 s\u0131ra, Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Mert D\u00f6\u015fkaya, Fen Fak\u00fcltesi Biyoloji B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. H\u00fcseyin Can, doktora \u00f6\u011frencileri Sedef Erkunt Alak, Ahmet Efe K\u00f6seo\u011flu ve y\u00fcksek lisans \u00f6\u011frencisi Mervenur G\u00fcvendi yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"

Prof. Dr. \u00dcn\u2019\u00fcn koronavir\u00fcs i\u00e7in a\u015f\u0131 geli\u015ftirme konusunda yapt\u0131\u011f\u0131 \u00e7al\u0131\u015fma Nature \u0130ndeks\u2019te yay\u0131mland\u0131 \u0130ZM\u0130R(Ege Ajans)-\u00a0Ege…<\/p>\n","protected":false},"author":2,"featured_media":1835,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1832","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gncl"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-scaled.jpg",2560,1702,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-300x199.jpg",300,199,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-768x511.jpg",640,426,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-1024x681.jpg",640,426,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-1536x1021.jpg",1536,1021,true],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-2048x1362.jpg",2048,1362,true],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-1024x681.jpg",1024,681,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2021\/01\/2-1-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"G\u00fcncel<\/a>","tag_info":"G\u00fcncel","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/1832","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=1832"}],"version-history":[{"count":2,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/1832\/revisions"}],"predecessor-version":[{"id":32577,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/1832\/revisions\/32577"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/1835"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=1832"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=1832"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=1832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}