{"id":17271,"date":"2023-10-23T05:49:00","date_gmt":"2023-10-23T05:49:00","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=17271"},"modified":"2023-10-23T06:51:28","modified_gmt":"2023-10-23T06:51:28","slug":"euden-erken-evre-akciger-kanserinin-tespitine-yonelik-onemli-proje","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2023\/10\/23\/euden-erken-evre-akciger-kanserinin-tespitine-yonelik-onemli-proje\/","title":{"rendered":"E\u00dc\u2019den erken evre akci\u011fer kanserinin tespitine y\u00f6nelik \u00f6nemli proje"},"content":{"rendered":"

Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Asl\u0131 Tetik Vardarl\u0131\u2019n\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cErken Evre Akci\u011fer Kanseri Tan\u0131l\u0131 Olgular\u0131n Ekshale Soluk Havas\u0131 Kondensat \u00d6rneklerinde Genomik Profilin Erken Tan\u0131 Biyobelirte\u00e7leri Olarak De\u011ferlendirilmesi\u201d ba\u015fl\u0131kl\u0131 proje, T\u00dcB\u0130TAK taraf\u0131ndan desteklenmeye uygun bulundu. Proje ile akci\u011fer kanseri erken evrede daha etkili \u015fekilde tespit edilerek, hastalar\u0131n ya\u015fam s\u00fcrelerinin uzamas\u0131na ve sa\u011fl\u0131k hizmetlerindeki y\u00fck\u00fcn azalmas\u0131na katk\u0131da bulunulacak.<\/p>\n

Proje ekibini tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201cSa\u011fl\u0131k alan\u0131nda T\u00fcrkiye\u2019nin referans merkezi konumunda bulunan \u00fcniversitemiz, T\u00dcB\u0130TAK\u2019a en \u00e7ok proje veren ve projesi en \u00e7ok kabul g\u00f6ren \u00fcniversitelerin ba\u015f\u0131nda geliyor. Do\u00e7. Dr. Asl\u0131 Tetik Vardarl\u0131 hocam\u0131z\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 proje ile en s\u0131k g\u00f6r\u00fclen kanserler aras\u0131nda yer alan akci\u011fer kanserinin erken tan\u0131s\u0131na y\u00f6nelik \u00e7al\u0131\u015fmalar y\u00fcr\u00fct\u00fclecek. Hocam\u0131z\u0131 ve ekibini tebrik ediyorum\u201d dedi.<\/p>\n

Akci\u011fer kanseri vakalar\u0131n\u0131n \u00fc\u00e7te ikisinin ileri evrelerde tespit edildi\u011fini s\u00f6yleyen Do\u00e7. Dr. Asl\u0131 Tetik Vardarl\u0131, \u201cBuna ba\u011fl\u0131 olarak cerrahi tedavi \u015fans\u0131 maalesef azal\u0131yor. Ortalama 5 y\u0131ll\u0131k akci\u011fer kanseri sa\u011fkal\u0131m oran\u0131, tan\u0131 an\u0131nda hastal\u0131\u011f\u0131n evresine ba\u011fl\u0131 olarak y\u00fczde 4\u00a0 ila 17 aras\u0131nda de\u011fi\u015fiyor. Bu sebeple akci\u011fer kanserinde erken tan\u0131ya y\u00f6nelik biyobelirte\u00e7lerin belirlenmesi olduk\u00e7a \u00f6nem ta\u015f\u0131yor. Bizim projemizdeki amac\u0131m\u0131z, erken evre akci\u011fer kanserinin molek\u00fcler patolojisinden sorumlu t\u00fcm somatik mutasyonlar\u0131 saptamak i\u00e7in non invaziv bir y\u00f6ntem olan ekshale soluk havas\u0131 kondensat\u00a0 \u00f6rneklerinden elde edilen cfDNA ile t\u00fcm genom dizi analizini ger\u00e7ekle\u015ftirerek, erken evre akci\u011fer kanserinin molek\u00fcler patogenezinden sorumlu de\u011fi\u015fikliklerin erken tan\u0131da biyobelirte\u00e7 olma \u00f6zelliklerini ortaya koymakt\u0131r. Projemizin \u00f6zg\u00fcnl\u00fc\u011f\u00fcn\u00fc, daha \u00f6nce t\u00fcm\u00f6r doku veya likit biyopsi \u00f6rneklerinde yap\u0131lan genomik analizler yerine, ekshale soluk havas\u0131 kondensat \u00f6rneklerinden eksrakte edilen cfDNA \u00f6rnekleri kullanarak t\u00fcm genom dizi analizini ger\u00e7ekle\u015ftirilmesi olu\u015fturuyor\u201d dedi.<\/p>\n

\u201cKanser hastalar\u0131 ile sa\u011fl\u0131kl\u0131 bireylerin genomik profilleri kar\u015f\u0131la\u015ft\u0131r\u0131lacak\u201d<\/b><\/p>\n

\"\"Projenin bir olgu-kontrol \u00e7al\u0131\u015fmas\u0131 oldu\u011funu belirten Do\u00e7. Dr. Tetik Vardarl\u0131, \u201cErken evre akci\u011fer kanseri tan\u0131s\u0131 alan olgular ile kanser tan\u0131s\u0131 almam\u0131\u015f sa\u011fl\u0131kl\u0131 bireylerden ekshale soluk havas\u0131 kondensat \u00f6rnekleri toplanacak. Bu \u00f6rnekler \u00fczerinde t\u00fcm genom dizi analizi ger\u00e7ekle\u015ftirilecek ve kanser hastalar\u0131nda saptanan genomik de\u011fi\u015fiklikler ile sa\u011fl\u0131kl\u0131 kontrol grubu kar\u015f\u0131la\u015ft\u0131r\u0131larak risk skorlar\u0131 belirlenecek. En y\u00fcksek risk skoruna sahip genler belirlenecek ve bu genler i\u00e7in bir akci\u011fer kanseri erken tan\u0131 paneli tasarlanacak. Bu panel kullan\u0131larak \u015f\u00fcpheli olgular\u0131n ekshale soluk havas\u0131 kondensat \u00f6rnekleri analiz edilecek ve genomik de\u011fi\u015fikliklerin hastal\u0131\u011f\u0131n erken tan\u0131s\u0131nda kullan\u0131labilirli\u011fi de\u011ferlendirilecek. Elde edece\u011fimiz bulgularla uzun vadede tasarlanmas\u0131 planlanan erken evre akci\u011fer kanser panelinin, daha b\u00fcy\u00fck hasta kohortunda, yeni nesil dizileme platformlar\u0131nda uygulanmas\u0131 ve klinik rutin prati\u011fimize girmesi durumunda hastalar\u0131n ya\u015fam s\u00fcrelerinin uzamas\u0131n\u0131 ve \u00a0t\u0131bbi harcamalarda etkili bir d\u00fc\u015f\u00fc\u015f sa\u011flanmas\u0131n\u0131 bekliyoruz. Daha ileriki zamanlarda ise ba\u015far\u0131ya ula\u015fmam\u0131z durumunda tasarlanmas\u0131 planlanan erken evre akci\u011fer kanseri panelini tescil ettirerek \u00fclke ekonomisine katk\u0131 sa\u011flamay\u0131 hedefliyoruz\u201d dedi.<\/p>\n

Do\u00e7. Dr. Tetik Vardarl\u0131, projenin kanser ara\u015ft\u0131rmalar\u0131nda ve hedefe y\u00f6nelik yeni tedavi stratejilerinin belirlenmesinde \u00f6nemli bir ad\u0131m olaca\u011f\u0131n\u0131 ve bilimsel literat\u00fcre katk\u0131 sa\u011flayarak T\u00fcrkiye\u2019nin ulusal ve uluslararas\u0131 d\u00fczeyde \u00f6nemli bir yer edinmesine yard\u0131mc\u0131 olaca\u011f\u0131n\u0131 \u00f6ng\u00f6rd\u00fcklerini belirtti.<\/p>\n

Multidisipliner ekip<\/b><\/p>\n

Proje ekibinde; E\u00dc Ege \u00dcniversitesi T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Cumhur G\u00fcnd\u00fcz, G\u00f6\u011f\u00fcs Hastal\u0131klar\u0131 Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Tuncay G\u00f6ksel, Patoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Ali Veral, Radyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Recep Sava\u015f, G\u00f6\u011f\u00fcs Cerrahisi Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Tevfik \u0130lker Ak\u00e7am, Fen Fak\u00fcltesi Kimya B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Prof. Dr. Levent Pelit, Uzman Dr. Haydar Karaku\u015f, Dr. Su \u00d6zg\u00fcr, Dr. Suat Seren G\u00f6\u011f\u00fcs Hastal\u0131klar\u0131 ve Cerrahisi E\u011fitim ve Ara\u015ft\u0131rma Hastanesinden Do\u00e7. Dr. Ozan Usluer, Mu\u011fla S\u0131tk\u0131 Ko\u00e7man \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji Anabilim Dal\u0131 Ar\u015f. G\u00f6r. Aycan A\u015f\u0131k yer al\u0131yor. Projenin dan\u0131\u015fmanl\u0131\u011f\u0131n\u0131 ise E\u00dc T\u0131p Fak\u00fcltesi G\u00f6\u011f\u00fcs Cerrahisi Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Kutsal Turhan ve Dr. Suat Seren G\u00f6\u011f\u00fcs Hastal\u0131klar\u0131 ve Cerrahisi E\u011fitim ve Ara\u015ft\u0131rma Hastanesinden Prof. Dr. Kenan Can Ceylan yap\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi T\u0131bbi Biyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Asl\u0131 Tetik Vardarl\u0131\u2019n\u0131n…<\/p>\n","protected":false},"author":2,"featured_media":17272,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-17271","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1.jpg",1600,1073,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1-300x201.jpg",300,201,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1-768x515.jpg",640,429,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1-1024x687.jpg",640,429,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1-1536x1030.jpg",1536,1030,true],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1.jpg",1600,1073,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1-1024x687.jpg",1024,687,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/10\/EGE-ASLI-TETIK-VARDARLI-VE-PROJE-EKIBI-1-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/17271","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=17271"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/17271\/revisions"}],"predecessor-version":[{"id":17274,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/17271\/revisions\/17274"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/17272"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=17271"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=17271"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=17271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}