{"id":16645,"date":"2023-09-18T05:25:00","date_gmt":"2023-09-18T05:25:00","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=16645"},"modified":"2023-09-18T07:28:23","modified_gmt":"2023-09-18T07:28:23","slug":"egeli-akademisyen-doc-dr-hasan-akbabadan-kansere-karsi-bagisikligi-guclendirecek-proje","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2023\/09\/18\/egeli-akademisyen-doc-dr-hasan-akbabadan-kansere-karsi-bagisikligi-guclendirecek-proje\/","title":{"rendered":"Egeli akademisyen\u00a0Do\u00e7. Dr. Hasan Akbaba\u2019dan kansere kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 g\u00fc\u00e7lendirecek proje"},"content":{"rendered":"

Bilim insanlar\u0131ndan \u00e7a\u011f\u0131n hastal\u0131\u011f\u0131n\u0131n tedavisine y\u00f6nelik \u00f6nemli \u00e7al\u0131\u015fma<\/p>\n

Egeli akademisyen<\/b>\u00a0Do\u00e7. Dr. Hasan Akbaba\u2019dan kansere kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 g\u00fc\u00e7lendirecek proje<\/b><\/p>\n

Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Farmas\u00f6tik Biyoteknoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Hasan Akbaba\u2019n\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc \u00fcstlendi\u011fi \u201cMeme Kanserine Kar\u015f\u0131 Ba\u011f\u0131\u015f\u0131kl\u0131k Sistemi Taraf\u0131ndan Tan\u0131nabilen Yapay Kanser H\u00fccresi ile \u0130mm\u00fcn Stim\u00fclasyonunun Sa\u011flanmas\u0131, Terap\u00f6tik ve Kanser A\u015f\u0131s\u0131 Potansiyelinin Ara\u015ft\u0131r\u0131lmas\u0131\u201d ba\u015fl\u0131kl\u0131 proje, T\u00dcB\u0130TAK 1001 \u2013 Bilimsel ve Teknolojik Ara\u015ft\u0131rma Projelerini Destekleme Program\u0131 kapsam\u0131nda desteklenmeye uygun bulundu. Proje kapsam\u0131nda \u00e7a\u011f\u0131n hastal\u0131\u011f\u0131 olan kanserin tedavisine y\u00f6nelik olarak ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin stim\u00fclasyonunu sa\u011flayan yapay kanser h\u00fccreleri geli\u015ftirilecek.<\/p>\n

Proje ekibini tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201c\u00dcniversitemizde olu\u015fturdu\u011fumuz s\u00fcrd\u00fcr\u00fclebilir bilim iklimi \u00e7er\u00e7evesinde \u00fcretken akademisyenlerimiz taraf\u0131ndan haz\u0131rlanan projeler, T\u00dcB\u0130TAK nezdinde desteklenmeye devam ediyor. Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim \u00fcyemiz Do\u00e7. Dr. Hasan Akbaba ve ekibinin ger\u00e7ekle\u015ftirdi\u011fi proje ile kanserin tedavisine y\u00f6nelik yapay kanser h\u00fccreleri geli\u015ftirilecek. Ayr\u0131ca meme kanserine kar\u015f\u0131 koruyucu bir a\u015f\u0131 geli\u015ftirilesi de hedefleniyor. Hocam\u0131z\u0131 ve ekibini \u00e7al\u0131\u015fmalar\u0131ndan \u00f6t\u00fcr\u00fc tebrik ediyorum\u201d dedi.<\/p>\n

\u201cYapay kanser h\u00fccreleri ile ba\u011f\u0131\u015f\u0131kl\u0131k desteklenecek\u201d<\/b><\/p>\n

\"\"Proje kapsam\u0131nda kanserin tedavisine y\u00f6nelik olarak ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin stim\u00fclasyonunu sa\u011flayan yapay kanser h\u00fccreleri geli\u015ftirilece\u011fini ifade eden Do\u00e7. Dr. Hasan Akbaba, \u201cBa\u011f\u0131\u015f\u0131kl\u0131k sisteminin heterojen stim\u00fclasyonu ve imm\u00fcnolojik sinapstaki etkile\u015fimi art\u0131rmak \u00fczere kanserli h\u00fccrelerin genetik modifikasyon ile tan\u0131nabilirli\u011finin art\u0131r\u0131lmas\u0131, dolay\u0131s\u0131yla ba\u011f\u0131\u015f\u0131kl\u0131k sistemine kar\u015f\u0131 duyarl\u0131l\u0131\u011f\u0131n\u0131n art\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r. Bu temelde ortaya koydu\u011fumuz hipotez; T h\u00fccreleri yerine kanser h\u00fccrelerinde ger\u00e7ekle\u015ftirilecek genetik modifikasyonlar ile kanser h\u00fccrelerinin ba\u011f\u0131\u015f\u0131k sistemden ka\u00e7\u0131\u015f mekanizmalar\u0131n\u0131n ortadan kald\u0131r\u0131lmas\u0131 ve antijen sunumunun stim\u00fclasyonu ile kanser h\u00fccrelerinin kamuflaj\u0131n\u0131n \u00f6nlenmesidir. \u00a0Organizmadaki anti-t\u00fcm\u00f6r T h\u00fccre aktivitesi art\u0131r\u0131larak t\u00fcm\u00f6r immunosurveillance kapsam\u0131nda ba\u011f\u0131\u015f\u0131kl\u0131k sistem lehine denge sa\u011flanabilecektir. Bu ama\u00e7la proje \u00f6nerimizde antijen sunumunun dentritik h\u00fccre membran\u0131 arac\u0131l\u0131\u011f\u0131yla ve gen ekspresyonu ile stim\u00fcle edildi\u011fi ve imm\u00fcn ka\u00e7\u0131\u015ftan sorumlu genlerin nakavt edildi\u011fi yapay kanser h\u00fccreleri form\u00fcle edilerek ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin bilin\u00e7li olarak y\u00f6nlendirilmesi, bir anlamda \u2018e\u011fitilmesi\u2019 ile ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin desteklenmesi planlanmaktad\u0131r.\u00a0 Geli\u015ftirilen yapay kanser h\u00fccresinin in vitro ve in vivo T h\u00fccresi aktivitesi analiz edilecek, meme kanseri fare ortotopik modelinde hem terap\u00f6tik hem de kanser a\u015f\u0131s\u0131 potansiyelinin de\u011ferlendirilmesi ger\u00e7ekle\u015ftirilecektir\u201d dedi.<\/p>\n

Projenin geli\u015fim s\u00fcrecini anlatan Do\u00e7. Dr. Akbaba, \u201cBu proje, lisans\u00fcst\u00fc e\u011fitimim s\u0131ras\u0131nda edindi\u011fim nanota\u015f\u0131y\u0131c\u0131 sistemler ve Harvard Medical School Immunoloji B\u00f6l\u00fcm\u00fcnde doktora sonras\u0131 ara\u015ft\u0131rmac\u0131 oldu\u011fum d\u00f6nemde edindi\u011fim altyap\u0131 birle\u015ftirilerek tasarlanm\u0131\u015ft\u0131r. Proje \u00f6nerimiz bir \u00f6nceki y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc ger\u00e7ekle\u015ftirdi\u011fim ve ge\u00e7ti\u011fimiz \u015fubat ay\u0131nda tamamlad\u0131\u011f\u0131m\u0131z T\u00dcB\u0130TAK 1001 projesinin devam\u0131 niteli\u011finde olup proje ekibimizin nihai hedefi meme kanserine kar\u015f\u0131 koruyucu ve terap\u00f6tik bir a\u015f\u0131n\u0131n geli\u015ftirilmesidir\u201d diye konu\u015ftu.<\/p>\n

Multidisipliner ara\u015ft\u0131rma ekibi<\/b><\/p>\n

Do\u00e7. Dr. Hasan Akbaba\u2019n\u0131n y\u00fcr\u00fct\u00fcc\u00fc oldu\u011fu proje ekibinde; Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Farmas\u00f6tik Biyoteknoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Ay\u015fe G\u00fclten Kantarc\u0131 ve Ege \u00dcniversitesi A\u015f\u0131 Geli\u015ftirme Uygulama ve Ara\u015ft\u0131rma Merkezi Y\u00f6netim Kurulu Ba\u015fkan Yard\u0131mc\u0131s\u0131 Prof. Dr. Mert D\u00f6\u015fkaya dan\u0131\u015fmanl\u0131k g\u00f6revini \u00fcstlenirken, \u00a0Dr. \u00d6\u011fr. \u00dcyesi Muhammet Karakavuk ara\u015ft\u0131rmac\u0131 olarak yer al\u0131yor. Projenin kurum d\u0131\u015f\u0131 payda\u015flar\u0131 ise \u0130zmir K\u00e2tip \u00c7elebi \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Farmas\u00f6tik Biyoteknoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. G\u00fcl\u015fah Erel Akbaba ve \u0130zmir Biyot\u0131p ve Genom Merkezinden Do\u00e7. Dr. \u015eerif \u015eent\u00fcrk.<\/p>\n","protected":false},"excerpt":{"rendered":"

Bilim insanlar\u0131ndan \u00e7a\u011f\u0131n hastal\u0131\u011f\u0131n\u0131n tedavisine y\u00f6nelik \u00f6nemli \u00e7al\u0131\u015fma Egeli akademisyen\u00a0Do\u00e7. Dr. Hasan Akbaba\u2019dan kansere kar\u015f\u0131…<\/p>\n","protected":false},"author":2,"featured_media":16646,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70],"tags":[],"class_list":["post-16645","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1.jpg",1600,1064,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1-768x511.jpg",640,426,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1-1024x681.jpg",640,426,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1-1536x1021.jpg",1536,1021,true],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1.jpg",1600,1064,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1-1024x681.jpg",1024,681,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/EGE-MUHAMMET-KARAKAVUK-AYSE-GULTEN-KANTARCI-NECDET-BUDAK-HASAN-AKBABA-MERT-DOSKAYA-1-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a>","tag_info":"Kamp\u00fcs","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/16645","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=16645"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/16645\/revisions"}],"predecessor-version":[{"id":16648,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/16645\/revisions\/16648"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/16646"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=16645"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=16645"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=16645"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}