Ege \u00dcniversitesi akademisyenleri, \u00f6zellikle hamilelerde ve ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 zay\u0131f insan ve hayvanlarda tehlikeli sonu\u00e7lar do\u011furabilen \u201cToksoplazma\u201d enfeksiyonuna kar\u015f\u0131 mRNA a\u015f\u0131s\u0131 geli\u015ftirmek ad\u0131na proje haz\u0131rlad\u0131. Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Fen Fak\u00fcltesi Biyoloji B\u00f6l\u00fcm\u00fc Molek\u00fcler Biyoloji Anabilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. H\u00fcseyin Can\u2019\u0131n yapt\u0131\u011f\u0131 \u201cToxoplasma gondii mRNA a\u015f\u0131s\u0131 \u00f6n \u00e7al\u0131\u015fmas\u0131: ROP6 mRNA transkriptlerinin \u00fcretimi, h\u00fccreli ve hu\u0308cresiz ortamlarda protein sentezi ve immu\u0308nojenitesinin belirlenmesi\u201d ba\u015fl\u0131kl\u0131 proje, \u00a0T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) taraf\u0131ndan da destekleniyor.<\/p>\n
Proje ekibini tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201cCovid-19 pandemisi bizlere bir kez daha a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131n\u0131n ne kadar \u00f6nemli oldu\u011funu ac\u0131 bir tecr\u00fcbe ile g\u00f6sterdi. Akademisyenlerimiz,\u00a0 pandemi d\u00f6neminde yayg\u0131n olarak kullan\u0131lan ve ba\u015far\u0131l\u0131 olan mRNA teknolojisi ile Toksoplazma enfeksiyonuna y\u00f6nelik a\u015f\u0131 geli\u015ftirecekler. Sa\u011fl\u0131k alan\u0131nda referans merkezi olan \u00fcniversitemiz, bu t\u00fcr \u00e7al\u0131\u015fmalar\u0131 s\u0131kl\u0131kla s\u00fcrd\u00fcrecek. Ara\u015ft\u0131rma ekibimizi tebrik ediyorum\u201d diye konu\u015ftu.<\/p>\n
\u201cParazite kar\u015f\u0131 tek m\u00fccadele yolu a\u015f\u0131\u201d<\/b><\/p>\n
Projenin amac\u0131n\u0131 anlatan Do\u00e7. Dr. H\u00fcseyin Can, \u201cProjede, insan ve hayvanlar\u0131 enfekte ederek toksoplazmozise neden olan Toxoplasma gondii\u2019ye kar\u015f\u0131 mRNA a\u015f\u0131s\u0131 geli\u015ftirmeyi hedefliyoruz. D\u00fcnyada insan n\u00fcfusunun 3\u2019te 1\u2019inin bu parazit ile enfekte oldu\u011fu tahmin ediliyor. Toksoplazmozisli sa\u011fl\u0131kl\u0131 bireylerde genellikle her hangi bir klinik belirti g\u00f6zlenmezken ba\u011f\u0131\u015f\u0131kl\u0131k sistemi zay\u0131flam\u0131\u015f olanlarda ciddi \u00f6l\u00fcmle sonu\u00e7lanabilen durumlar ortaya \u00e7\u0131kabilmekte. Ayr\u0131ca, hamilelik d\u00f6neminde al\u0131nd\u0131\u011f\u0131nda fet\u00fcse ge\u00e7erek d\u00fc\u015f\u00fcklere ve do\u011fumsal anomalilere de neden olabilmekte. Di\u011fer taraftan veterinerlik alan\u0131nda da s\u0131kl\u0131kla koyunlarda d\u00fc\u015f\u00fcklere sebep olarak ciddi ekonomik kay\u0131plara yol a\u00e7\u0131yor. \u0130nsanlarda ve hayvanlarda kronik enfeksiyona sebep olan doku kistlerinin tedavisine y\u00f6nelik etkin bir ilac\u0131n olmamas\u0131 sebebiyle bu parazitle m\u00fccadelede a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131na ihtiya\u00e7 var. G\u00fcn\u00fcm\u00fczde sadece koyunlarda kullan\u0131m\u0131 ruhsatland\u0131r\u0131lm\u0131\u015f Toxovax a\u015f\u0131s\u0131n\u0131n var olmas\u0131, toksoplasmozise kar\u015f\u0131 etkin a\u015f\u0131 geli\u015ftirilebilece\u011fini g\u00f6steriyor\u201d dedi.<\/p>\n
\u201cmRNA teknolojisinin parazitler i\u00e7in kullan\u0131labilece\u011fi g\u00f6sterilecek\u201d<\/b><\/p>\n
mRNA a\u015f\u0131lar\u0131n\u0131n koronavir\u00fcs pandemisinde ba\u015far\u0131yla uyguland\u0131\u011f\u0131n\u0131 dile getiren Do\u00e7. Dr. Can, \u201cG\u00fcn\u00fcm\u00fczde COVID-19 pandemisine kar\u015f\u0131 kullan\u0131lan \u2018mRNA a\u015f\u0131 platformu\u2019 geni\u015f kitlelere ba\u015far\u0131l\u0131 bir \u015fekilde uygulanm\u0131\u015ft\u0131r. Bu sebeple de di\u011fer bula\u015f\u0131c\u0131 patojenlere kar\u015f\u0131 ba\u015far\u0131s\u0131n\u0131n h\u0131zl\u0131ca test edilece\u011fi a\u00e7\u0131kt\u0131r. Projemiz kapsam\u0131nda \u2018Toxoplasma gondii ROP6 proteinini kodlayan bir mRNA a\u015f\u0131s\u0131 geli\u015ftirilmesi\u2019 i\u00e7in \u00f6n \u00e7al\u0131\u015fmalar planland\u0131. Buna ba\u011fl\u0131 olarak projede Toxoplasma gondii ROP6 proteini sentezleyen mRNA transkriptleri \u00fcretilecek, sonras\u0131nda sentezlenen ROP6 proteinin antijenikli\u011fi ba\u011f\u0131\u015f\u0131k serum \u00f6rnekleri ile test edilerek g\u00f6sterilecek. \u00a0Sonu\u00e7 olarak; \u00a0hem insanlar hem de \u00e7iftlik hayvanlar\u0131 i\u00e7in \u00f6nemli bir parazit olan Toxoplasma gondii\u2019ye kar\u015f\u0131 etkinli\u011fi deney hayvanlar\u0131nda test edilmeye haz\u0131r mRNA a\u015f\u0131s\u0131n\u0131n \u00f6n \u00e7al\u0131\u015fmas\u0131 tamamlanm\u0131\u015f olacak. Dahas\u0131, bu proje ile birlikte COVID-19\u2019a kar\u015f\u0131 ba\u015far\u0131l\u0131 olan mRNA a\u015f\u0131lar\u0131n\u0131n sadece vir\u00fcslere kar\u015f\u0131 de\u011fil insanlarda salg\u0131nlara neden olabilecek parazitler i\u00e7in de kullan\u0131labilece\u011fi g\u00f6sterilmi\u015f olacak\u201d diye konu\u015ftu.<\/p>\n
Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Do\u00e7. Dr. H\u00fcseyin Can\u2019\u0131n yapt\u0131\u011f\u0131 proje ekibinde; \u00a0E\u00dc Fen Fak\u00fcltesi Molek\u00fcler Biyoloji Anabilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Prof. Dr. Cemal \u00dcn, \u00a0E\u00dc A\u015f\u0131 Geli\u015ftirme Uygulama ve Ara\u015ft\u0131rma Merkezi \u00d6\u011fretim \u00dcyeleri; Prof. Dr. Y\u00fcksel G\u00fcr\u00fcz, Prof. Dr. Mert D\u00f6\u015fkaya, Do\u00e7. Dr. Aysu De\u011firmenci D\u00f6\u015fkaya ve Dr. \u00d6\u011fr. \u00dcyesi Muhammet Karakavuk yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi akademisyenleri, \u00f6zellikle hamilelerde ve ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 zay\u0131f insan ve hayvanlarda tehlikeli sonu\u00e7lar do\u011furabilen \u201cToksoplazma\u201d…<\/p>\n","protected":false},"author":2,"featured_media":16536,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1],"tags":[],"class_list":["post-16535","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un.jpg",1404,928,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un-300x198.jpg",300,198,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un-768x508.jpg",640,423,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un-1024x677.jpg",640,423,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un.jpg",1404,928,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un.jpg",1404,928,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un-1024x677.jpg",1024,677,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/09\/Mert-Doskaya-Yuksel-Guruz-Necdet-Budak-Huseyin-Can-Cemal-Un-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a>","tag_info":"G\u00fcncel","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/16535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=16535"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/16535\/revisions"}],"predecessor-version":[{"id":16537,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/16535\/revisions\/16537"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/16536"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=16535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=16535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=16535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}