Ege \u00dcniversitesi ve \u0130zmir K\u00e2tip \u00c7elebi \u00dcniversitesi bilim insanlar\u0131 bu proje i\u00e7in bir araya geldiler<\/p>\n
N\u00f6rodejeneratif hastal\u0131klar\u0131n tan\u0131 ve tedavisine y\u00f6nelik \u00f6nemli proje<\/b><\/p>\n
\u00a0<\/b>Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim \u00fcyesi Prof. Dr. Emel \u00d6yk\u00fc \u00c7etin Uyan\u0131kgil ile \u0130zmir K\u00e2tip \u00c7elebi \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim \u00fcyesi Prof. Dr. Mutlu Aytemir\u2019in yapt\u0131\u011f\u0131 proje T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) taraf\u0131ndan desteklenmeye uygun bulundu.<\/p>\n
Ege \u00dcniversitesi ve \u0130zmir K\u00e2tip \u00c7elebi \u00dcniversitesi bilim insanlar\u0131 i\u015f birli\u011finde haz\u0131rlanan \u201cParkinson Tedavisinde Yeni \u0130la\u00e7 Geli\u015ftirme ve Form\u00fclasyon \u00c7al\u0131\u015fmalar\u0131: KOJI MG84\u2019\u00fcn Anti-N\u00f6rodejeneratif ve N\u00f6roprotektif Etkisinin In Vitro\/In Vivo \u0130ncelenmesi ve Farmakokinetik Ara\u015ft\u0131rmalar\u0131\u201d ba\u015fl\u0131kl\u0131 proje T\u00dcSEB\u2019ten destek almaya hak kazand\u0131.<\/p>\n
Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201cD\u00fcnyada pek \u00e7ok ki\u015fiyi etkileyen, n\u00f6rodejeneratif hastal\u0131klar bilim d\u00fcnyas\u0131n\u0131n son d\u00f6nemde \u00fczerine yo\u011funla\u015ft\u0131\u011f\u0131 alanlar\u0131n ba\u015f\u0131nda geliyor. \u00d6zellikle ileri ya\u015fa ba\u011fl\u0131 olarak sinir h\u00fccrelerinin ve sinir sistemi fonksiyonlar\u0131n\u0131n kaybedilmesine neden olan n\u00f6rodejeneratif hastal\u0131klar\u0131n g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131n\u0131n hem d\u00fcnyada hem de \u00fclkemizde gittik\u00e7e artt\u0131\u011f\u0131n\u0131 g\u00f6r\u00fcyoruz. \u0130leriki y\u0131llarda tehlikeli boyutlara ula\u015faca\u011f\u0131 tahmin edilen bu hastal\u0131k grubunun tan\u0131 ve tedavisine y\u00f6nelik \u00f6nemli bir ara\u015ft\u0131rmaya \u0130zmir\u2019imizin iki g\u00fczide \u00fcniversitesinden bilim insanlar\u0131 \u00f6nc\u00fcl\u00fck ediyorlar. Bilim ekibimizi tebrik ediyor, ba\u015far\u0131lar diliyorum\u201d dedi.<\/p>\n
Proje y\u00fcr\u00fct\u00fcc\u00fclerinden Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim \u00fcyesi Prof. Dr. Emel \u00d6yk\u00fc \u00c7etin Uyan\u0131kgil, \u201cN\u00f6rodejeneratif hastal\u0131klar, Merkezi Sinir Sisteminde (MSS) hasarl\u0131 h\u00fccre varl\u0131\u011f\u0131 ya da h\u00fccre kay\u0131plar\u0131 ile ortaya \u00e7\u0131kan patolojik durumlar olup, beynin \u00f6zellikli b\u00f6lgelerindeki n\u00f6ronlar\u0131n progresif ve geri d\u00f6n\u00fc\u015f\u00fcms\u00fcz kayb\u0131 ile karakterizedir. N\u00f6ron hasar\u0131 ya da kayb\u0131, h\u00fccre t\u00fcr\u00fcne ve MSS\u2019de bulundu\u011fu b\u00f6lgeye ba\u011fl\u0131 olarak, psikolojik ve davran\u0131\u015fsal bozukluklara neden olmaktad\u0131r. Parkinson hastal\u0131\u011f\u0131, dopaminerjik n\u00f6ronlar\u0131n kayb\u0131ndan kaynaklanan ikinci en yayg\u0131n n\u00f6rodejeneratif hastal\u0131kt\u0131r. Patentli bir bile\u015fik olan KOJI MG84\u2019\u00fcn g\u00fc\u00e7l\u00fc bir tirozinaz inhibit\u00f6r\u00fc olmas\u0131ndan dolay\u0131 ba\u015fta Parkinson hastal\u0131\u011f\u0131 olmak \u00fczere n\u00f6rodejeneratif hastal\u0131klar\u0131n tedavisinde etkili bir ajan olabilece\u011fi \u00f6ng\u00f6r\u00fclmektedir. Y\u00fcr\u00fcmekte olan proje kapsam\u0131nda KOJI MG84 sentezlenmi\u015f olup niozom form\u00fclasyonu geli\u015ftirilmi\u015ftir. H\u00fccre k\u00fclt\u00fcr\u00fc deneyleri ile anti-n\u00f6rodejeneratif ve n\u00f6roprotektif etkilerinin saptanmas\u0131, son olarak in vivo Parkinson hayvan modellerinde bile\u015fi\u011fin anti-n\u00f6rodejeneratif ve n\u00f6roprotektif etkilerinin ara\u015ft\u0131r\u0131lmas\u0131 ve farmakokinetik \u00e7al\u0131\u015fmalar\u0131 yap\u0131lacakt\u0131r\u201d diye konu\u015ftu.<\/p>\n
Projede; \u0130zmir K\u00e2tip \u00c7elebi \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim elemanlar\u0131 Prof. Dr. Canan Sevimli G\u00fcr, Dr. \u00d6\u011fr. \u00dcyesi G\u00fcl\u015fah Karakaya ve Dr. \u00d6\u011fr. \u00dcyesi Merve Saylam ile Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi \u00f6\u011fretim \u00fcyesi Prof. Dr. Yi\u011fit Uyan\u0131kgil, Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim \u00fcyesi Prof. Dr. Mustafa Emrah K\u0131l\u0131n\u00e7, M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Aylin \u015eendemir ile Dr. Ece Bay\u0131r ve y\u00fcksek lisans \u00f6\u011frencisi Zehra G\u00fcl Mor\u00e7imen ara\u015ft\u0131rmac\u0131 olarak yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi ve \u0130zmir K\u00e2tip \u00c7elebi \u00dcniversitesi bilim insanlar\u0131 bu proje i\u00e7in bir araya geldiler…<\/p>\n","protected":false},"author":2,"featured_media":15629,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1],"tags":[],"class_list":["post-15628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-scaled.jpg",2560,2028,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-300x238.jpg",300,238,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-768x608.jpg",640,507,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-1024x811.jpg",640,507,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-1536x1217.jpg",1536,1217,true],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-2048x1622.jpg",2048,1622,true],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-1024x811.jpg",1024,811,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/07\/Prof.-Dr.-Emel-Oyku-Cetin-Uyanikgil-Prof.-Dr.-Necdet-Budak-Prof.-Dr.-Yigit-Uyanikgil-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a>","tag_info":"G\u00fcncel","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/15628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=15628"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/15628\/revisions"}],"predecessor-version":[{"id":15630,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/15628\/revisions\/15630"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/15629"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=15628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=15628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=15628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}