{"id":14718,"date":"2023-05-10T06:53:33","date_gmt":"2023-05-10T06:53:33","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=14718"},"modified":"2023-05-10T06:53:34","modified_gmt":"2023-05-10T06:53:34","slug":"egeli-akademisyen-doc-dr-sarikahya-ve-ekibi-meme-kanserine-karsi-endemik-bitki-turu-ile-arastirma-yapacak","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2023\/05\/10\/egeli-akademisyen-doc-dr-sarikahya-ve-ekibi-meme-kanserine-karsi-endemik-bitki-turu-ile-arastirma-yapacak\/","title":{"rendered":"Egeli akademisyen Do\u00e7. Dr. Sar\u0131kahya ve ekibi meme kanserine kar\u015f\u0131 endemik bitki t\u00fcr\u00fc ile ara\u015ft\u0131rma yapacak<\/strong>"},"content":{"rendered":"

Ege \u00dcniversitesi(E\u00dc) Fen Fak\u00fcltesi Kimya B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. Nazl\u0131 Sar\u0131kahya\u2019n\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 proje, T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) \u201cStratejik Sa\u011fl\u0131k Teknolojilerine Y\u00f6nelik Ar-Ge Proje \u00c7a\u011fr\u0131s\u0131\u201d kapsam\u0131nda desteklenmeye uygun bulundu. Do\u00e7. Dr. Sar\u0131kahya ve ekibi\u00a0 \u201cEndemik\u00a0<\/i>\u2018Cephalaria\u2019 T\u00fcrlerinden \u0130zole Edilen \u0130mmunomod\u00fclat\u00f6r Saponin Adjuvan Adaylar\u0131n\u0131n Meme Kanseri A\u015f\u0131lar\u0131nda A\u015f\u0131 Antijeni Her2\/Neu Peptidi ile kullan\u0131m potansiyelinin ara\u015ft\u0131r\u0131lmas\u0131\u201d projesinde meme kanserine y\u00f6nelik ara\u015ft\u0131rmalarda bulunacak.<\/p>\n

Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, Do\u00e7. Dr. Nazl\u0131 Sar\u0131kahya ve ekibini makam\u0131nda a\u011f\u0131rlayarak tebrik etti. Prof. Dr. Budak, \u201c Fen Fak\u00fcltesi Kimya B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00fcyemiz Do\u00e7. Dr. Nazl\u0131 Sar\u0131kahya hocam\u0131z ve ekibinin meme kanserine y\u00f6nelik geli\u015ftirdikleri proje TUSEB taraf\u0131ndan desteklenmeye hak kazand\u0131. Hocam\u0131z\u0131 ve ekibini tebrik eder, \u00e7al\u0131\u015fmalar\u0131nda ba\u015far\u0131lar dilerim\u201d dedi.<\/p>\n

Adjuvan kullan\u0131m\u0131 ile a\u015f\u0131 geli\u015ftirilecek<\/p>\n

\"\"Meme kanseri vakalar\u0131nda \u201cHER2\u201d pozitif t\u00fcr\u00fcn\u00fcn etkin oldu\u011funu buna y\u00f6nelik ara\u015ft\u0131rmalarda bulunduklar\u0131n\u0131 ifade eden Do\u00e7. Dr. Sar\u0131kahya, \u201c \u201cBilimsel verilere g\u00f6re \u00fclkemiz kad\u0131nlar\u0131nda y\u00fczde 43 gibi y\u00fcksek bir oranla ilk s\u0131rada yer alan meme kanser vakalar\u0131n\u0131n y\u00fczde 20-30\u2019u HER2 pozitif t\u00fcrd\u00fcr. G\u00fcn\u00fcm\u00fczde HER2 pozitif meme kanserine kar\u015f\u0131 klinikte HER2 spesifik monoklonal antikorlar uzun y\u0131llard\u0131r etkin tedavi y\u00f6ntemleri aras\u0131nda yer al\u0131yor. G\u00fcn\u00fcm\u00fczde biyoteknolojik y\u00f6ntemlerle \u00fcretilen bu antikorlar kadar aktif olarak ba\u011f\u0131\u015f\u0131kl\u0131k sistemini ind\u00fckleyecek HER2 peptidi i\u00e7eren a\u015f\u0131 form\u00fclasyonlar\u0131n\u0131n geli\u015ftirilmesi \u00f6nem arz ediyor. Son y\u0131llarda g\u00fc\u00e7l\u00fc koruyucu yan\u0131t olu\u015fturmada adjuvan kullan\u0131m\u0131na ihtiya\u00e7 duyan farkl\u0131 orijine sahip a\u015f\u0131lar ve antijenler bir\u00e7ok ara\u015ft\u0131rman\u0131n konusunu olu\u015fturuyor. \u00a0Adjuvan kullan\u0131m\u0131 sayesinde imm\u00fcnojenitesi az olan bir antijenin imm\u00fcnojenitesi art\u0131r\u0131labilmekte, daha az antijenle imm\u00fcn yan\u0131t ind\u00fcklenebilmekte ve a\u015f\u0131n\u0131n etkinli\u011fi uzat\u0131labilmektedir. Son y\u0131llarda adjuvanlar\u0131n kombinasyon \u015feklinde kullan\u0131lmas\u0131 \u00fczerinde \u00e7al\u0131\u015f\u0131l\u0131yor. Bu sayede imm\u00fcn sistem \u00fczerinde daha g\u00fc\u00e7l\u00fc bir etkinin olu\u015fturulmas\u0131 hedefleniliyor. Saponinler, bir triterpenik veya steroidal yap\u0131 \u00fczerinde \u015feker \u00fcniteleri ta\u015f\u0131yan sekonder metabolitlerdir. \u0130mm\u00fcn sistem \u00fczerindeki etkilerinden dolay\u0131 sahip olduklar\u0131 imm\u00fcnomod\u00fclat\u00f6r etkileri nedeniyle adjuvan potansiyeli g\u00f6stermektedirler\u201d diye konu\u015ftu.<\/p>\n

Cephalaria endemik bitkisi ile a\u015f\u0131 kombinasyonlar\u0131 yap\u0131lacak<\/b><\/p>\n

Proje hakk\u0131nda detayl\u0131 bilgi veren Do\u00e7. Dr. Sar\u0131kahya, \u201cBu proje kapsam\u0131nda, meme kanseri tedavisinde HER2\/Neu onkoproteinpeptid antijeni ile Cephalaria bitkilerinden elde edilen potansiyel saponin adjuvan\u0131 i\u00e7eren a\u015f\u0131 kombinasyonlar\u0131n\u0131n geli\u015ftirmesi ama\u00e7lanmaktad\u0131r. Bu ama\u00e7la, \u00fclkemiz endemik\u00a0Cephalaria spp<\/i>. t\u00fcrlerinden elde edilen adjuvan potansiyeline sahip saponin molek\u00fclleri ile \u00a0etkili a\u015f\u0131 kombinasyonunun t\u00fcm\u00f6r boyutunu k\u00fc\u00e7\u00fcltmesi, tamamen ortadan kald\u0131rmas\u0131 veya olu\u015fumunu engellemesini sa\u011flayacak bir form\u00fcl\u00fcn geli\u015ftirilmesi projenin en kayda de\u011fer sonucu olacakt\u0131r. Bu \u00e7al\u0131\u015fma ile HER2\/Neu peptidi, Cephalaria spp. saponin adjuvan\u0131 kombinasyonunun ilk kez denenmesi ve al\u0131nacak olumlu sonu\u00e7lar, meme kanserine kar\u015f\u0131 olu\u015fturulan bu kombinasyonun ileride farkl\u0131 antijenlerle kullan\u0131m\u0131n\u0131 da yayg\u0131nla\u015ft\u0131racak, sa\u011fl\u0131k sekt\u00f6r\u00fcndeki ve adjuvan olarak \u00fcretiminin ticari boyutta \u00fcretim de\u011ferini de art\u0131racak. Ayr\u0131ca ticarile\u015fme basama\u011f\u0131nda elde edilecek kombinasyon verileri yerli firmalara sunularak \u00fclkemizdeki imkanlarla \u00fcretilmesine potansiyel olu\u015fturacak y\u00f6nde \u00f6nemli bir ad\u0131m\u0131n at\u0131lmas\u0131 sa\u011flanacak\u201d dedi<\/p>\n

Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Do\u00e7. Dr. Nazl\u0131 Sar\u0131kahya\u2019n\u0131n yapt\u0131\u011f\u0131 projede E\u00dc Biyom\u00fchendislik B\u00f6l\u00fcm\u00fcnden Prof. Dr. Ay\u015fe Nalbantsoy, Eczac\u0131l\u0131k Fak\u00fcltesinden Prof. Dr. Emel \u00d6yk\u00fc \u00c7etin Uyan\u0131kgil, N\u00fckleer Bilimler Enstit\u00fcs\u00fcnden Prof. Dr. Fatma Yurt Onaran, T\u0131p Fak\u00fcltesinden Prof. Dr. Osman Zekio\u011flu ve\u00a0 \u00d6\u011fr. G\u00f6r. G\u00fcrdeniz Serin, Akdeniz \u00dcniversitesi Botanik B\u00f6l\u00fcm\u00fcnden Prof. Dr. Ramazan S\u00fcleyman G\u00f6kt\u00fcrk, Bo\u011fazi\u00e7i \u00dcniversitesi Molek\u00fcler Biyoloji B\u00f6l\u00fcm\u00fcnden Prof. Dr. Nesrin \u00d6z\u00f6ren\u00a0 ve Nezahat G\u00f6kyi\u011fit Botanik Bah\u00e7esinden Uzm. Bio. Bur\u00e7in \u00c7\u0131ngay yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ege \u00dcniversitesi(E\u00dc) Fen Fak\u00fcltesi Kimya B\u00f6l\u00fcm\u00fc \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. Nazl\u0131 Sar\u0131kahya\u2019n\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 proje,…<\/p>\n","protected":false},"author":2,"featured_media":14719,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-14718","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/05\/EGE-Doc.-Dr.-Nazli-Sarikahya-Prof.-Dr.-Ayse-Nalbantsoy-Prof.Dr_.Necdet-Budak-Prof.-Dr.-Oyku-Uyanikgil-2-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/14718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=14718"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/14718\/revisions"}],"predecessor-version":[{"id":14721,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/14718\/revisions\/14721"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/14719"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=14718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=14718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=14718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}