{"id":14450,"date":"2023-04-18T05:31:00","date_gmt":"2023-04-18T05:31:00","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=14450"},"modified":"2023-04-18T07:33:04","modified_gmt":"2023-04-18T07:33:04","slug":"prof-dr-uyanikgilden-kolon-ve-rektum-kanserlerinin-tedavisine-yonelik-proje","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2023\/04\/18\/prof-dr-uyanikgilden-kolon-ve-rektum-kanserlerinin-tedavisine-yonelik-proje\/","title":{"rendered":"Prof. Dr. Uyan\u0131kgil\u2019den kolon ve rektum kanserlerinin tedavisine y\u00f6nelik proje<\/strong>"},"content":{"rendered":"

Egeli bilim insanlar\u0131n\u0131n \u00e7a\u011f\u0131n hastal\u0131\u011f\u0131na y\u00f6nelik ara\u015ft\u0131rmalar\u0131 T\u00dcB\u0130TAK\u2019tan destek almaya devam ediyor<\/p>\n

Prof. Dr. Uyan\u0131kgil\u2019den kolon ve rektum kanserlerinin tedavisine y\u00f6nelik proje<\/b><\/p>\n

Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim \u00fcyesi Prof. Dr. Emel \u00d6yk\u00fc \u00c7etin Uyan\u0131kgil\u2019in y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcnde, d\u00fcnyada en s\u0131k g\u00f6r\u00fclen kanser t\u00fcrlerinden olan kolon ve rektum kanserlerinin tedavisine y\u00f6nelik haz\u0131rlanan proje T\u00dcB\u0130TAK\u2019tan destek almaya hak kazand\u0131.<\/p>\n

Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Eczac\u0131l\u0131k Teknolojisi B\u00f6l\u00fcm\u00fc Farmas\u00f6tik Teknoloji Anabilim Dal\u0131 Biyofarmas\u00f6tik ve Farmakokinetik Bilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Emel \u00d6yk\u00fc \u00c7etin Uyan\u0131kgil\u2019in y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cDeneysel Kolon Kanseri Modelinde Kapesitabin, \u0130ndometazin ve Metformin Kombinasyonunu \u0130\u00e7eren Nanopartik\u00fcler Sistemlerin Etkinli\u011finin \u0130ncelenmesi\u201d ba\u015fl\u0131kl\u0131 proje T\u00dcB\u0130TAK taraf\u0131ndan desteklenmeye uygun bulundu. Ba\u015far\u0131l\u0131 bilim insan\u0131 Prof. Dr. Emel \u00d6yk\u00fc \u00c7etin Uyan\u0131kgil\u2019i ve proje ekibini makam\u0131nda a\u011f\u0131rlayarak tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, Ege \u00dcniversitesi akademisyenleri taraf\u0131ndan y\u00fcr\u00fct\u00fclen projelerin T\u00dcB\u0130TAK taraf\u0131ndan destek g\u00f6rmeye devam etti\u011fini belirtti.<\/p>\n

Prof. Dr. Emel \u00d6yk\u00fc \u00c7etin Uyan\u0131kgil, \u201cKolorektal kanser d\u00fcnya genelinde en \u00e7ok te\u015fhis konulan kanser t\u00fcr\u00fcd\u00fcr. Kanser tedavisi s\u0131ras\u0131nda g\u00f6r\u00fclen yan etkiler ve hastalar\u0131n tedaviye verdikleri cevaplar tedavinin ba\u015far\u0131s\u0131n\u0131 etkilemektedir. Konvansiyonel tedavide g\u00f6zlenen olumsuzluklar\u0131 ortadan kald\u0131rmak ya da en aza indirgemek, h\u00fccresel d\u00fczeylere ta\u015f\u0131nmay\u0131 art\u0131rmak, ila\u00e7lar\u0131n dola\u015f\u0131mdaki konsantrasyonunu art\u0131rmak, sal\u0131m kinetiklerini optimize etmek, ila\u00e7lar\u0131n farmakokinetik ve farmakodinamik \u00f6zeliklerini de\u011fi\u015ftirmek, d\u00fc\u015f\u00fck ya da y\u00fcksek dozlarda etkin ve g\u00fcvenli tedavi sa\u011flamak ve en \u00f6nemlisi de v\u00fccudun di\u011fer b\u00f6lgelerinde istenmeyen herhangi bir etkiye neden olmadan hedef b\u00f6lgede istenilen d\u00fczeyde terap\u00f6tik yan\u0131t elde etmek i\u00e7in kontroll\u00fc sal\u0131m sistemleri hedeflenmektedir\u201d dedi.<\/p>\n

Projenin konusu ve amac\u0131yla ilgili bilgi veren Prof. Dr. Emel \u00d6yk\u00fc \u00c7etin Uyan\u0131kgil, \u201cProjenin konusu; anti-kanser etkinlikleri bilinen kapesitabin, antiinflamatuvar bir ila\u00e7 olan indometazin ve antidiyabetik bir ila\u00e7 olan metformin kombinasyonun hem\u00a0in vitro<\/i>\u00a0ko\u015fullarda hem de deneysel kolon kanseri olu\u015fturulmu\u015f hayvan modelinde enterik kaps\u00fcl haz\u0131rlanarak bu ila\u00e7lar\u0131n etkinli\u011finin incelenmesidir. Y\u00fcr\u00fct\u00fclmekte olan projede etkin maddeleri i\u00e7eren form\u00fclasyonlar geli\u015ftirilmi\u015f olup h\u00fccre k\u00fclt\u00fcr\u00fc \u00e7al\u0131\u015fmalar\u0131 devam etmektedir. Proje kapsam\u0131nda amac\u0131m\u0131z rutin tedavide uygulanan kapesitabin etkin maddesinin istenmeyen yan etkilerini azaltmak ve biyoyararlan\u0131m\u0131n\u0131 artt\u0131rmak i\u00e7in folik asitle fonksiyonelle\u015ftirilmi\u015f mezoporlu silika nanopartik\u00fcller sentezleyip, hedeflendirilmi\u015f bu nanopartik\u00fcllerin\u00a0in vitro<\/i>\u00a0ve\u00a0in vivo<\/i>\u00a0ko\u015fullarda anti-kanser etkinli\u011fi indometazin ve metformin i\u00e7eren niozom form\u00fclasyonlar\u0131 kombine olarak incelemektir\u201d diye konu\u015ftu.<\/p>\n

Multidisipliner proje ekibi<\/b><\/p>\n

Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Prof. Dr. Emel \u00d6yk\u00fc \u00c7etin Uyan\u0131kgil\u2019in yapt\u0131\u011f\u0131 projede Eczac\u0131l\u0131k Fak\u00fcltesi \u00f6\u011fretim \u00fcyeleri; Prof. Dr. Mustafa Emrah K\u0131l\u0131n\u00e7, Do\u00e7. Dr. Derya \u0130lem \u00d6zdemir, T\u0131p Fak\u00fcltesi Histoloji ve Embriyoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Yi\u011fit Uyan\u0131kgil, Biyoistatistik ve T\u0131bbi Bili\u015fim Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Timur K\u00f6se, Fen Fak\u00fcltesi Biyokimya B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Prof. Dr. \u015eenay \u015eanl\u0131er, ara\u015ft\u0131rmac\u0131 olarak Uzm. Dr. Canberk Tomruk, bursiyer olarak ise Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc Farmas\u00f6tik Teknoloji Anabilim Dal\u0131\/ Biyofarmas\u00f6tik ve Farmakokinetik Bilim Dal\u0131 doktora \u00f6\u011frencileri\u00a0Emine Esin \u00c7al\u0131\u015fkan ve Yal\u00e7\u0131n \u00c7elik Ayd\u0131n g\u00f6rev al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"

Egeli bilim insanlar\u0131n\u0131n \u00e7a\u011f\u0131n hastal\u0131\u011f\u0131na y\u00f6nelik ara\u015ft\u0131rmalar\u0131 T\u00dcB\u0130TAK\u2019tan destek almaya devam ediyor Prof. Dr. Uyan\u0131kgil\u2019den…<\/p>\n","protected":false},"author":2,"featured_media":14451,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-14450","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1.jpg",1422,922,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1-300x195.jpg",300,195,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1-768x498.jpg",640,415,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1-1024x664.jpg",640,415,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1.jpg",1422,922,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1.jpg",1422,922,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1-1024x664.jpg",1024,664,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/04\/YalcinCelikAydin-EmineEsinCaliskan-OykuUyanikgil-NecdetBudak-YigitUyanikgil-TimurKose-1-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/14450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=14450"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/14450\/revisions"}],"predecessor-version":[{"id":14452,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/14450\/revisions\/14452"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/14451"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=14450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=14450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=14450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}