{"id":13920,"date":"2023-03-02T06:52:46","date_gmt":"2023-03-02T06:52:46","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=13920"},"modified":"2023-03-02T06:52:47","modified_gmt":"2023-03-02T06:52:47","slug":"prof-dr-yesil-celiktas-ve-ekibi-cip-ustu-meme-kanseri-modeli-gelistirdi","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2023\/03\/02\/prof-dr-yesil-celiktas-ve-ekibi-cip-ustu-meme-kanseri-modeli-gelistirdi\/","title":{"rendered":"<strong>Prof. Dr. Ye\u015fil \u00c7elikta\u015f ve ekibi \u00e7ip \u00fcst\u00fc meme kanseri modeli geli\u015ftirdi<\/strong>"},"content":{"rendered":"<p style=\"text-align: justify;\">Ege \u00dcniversitesi (E\u00dc), nitelikli akademik faaliyetleriyle hem bilim d\u00fcnyas\u0131na hem de insanl\u0131\u011fa katk\u0131 sunmaya devam ediyor. E\u00dc M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f taraf\u0131ndan y\u00fcr\u00fct\u00fclen \u201cYeni Terap\u00f6tiklerin Test Edilmesi \u0130\u00e7in 3B Biyomimetik Meme Kanseri \u0130nvazyon Modeli\u201d ba\u015fl\u0131kl\u0131 proje T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu (T\u00dcB\u0130TAK) Uluslararas\u0131 \u0130\u015fbirli\u011fi Projeleri Ara\u015ft\u0131rma Destek Grubu (UPAG) Polonya Ulusal Ara\u015ft\u0131rma ve Geli\u015ftirme Merkezi (NCBR) taraf\u0131ndan desteklendi. Projede geli\u015ftirilen \u00e7ip \u00fcst\u00fc meme kanseri modeliyle meme kanserinin yay\u0131l\u0131m g\u00f6sterme s\u00fcrecindeki farkl\u0131 a\u015famalar\u0131 en iyi \u015fekilde taklit edilirken, hayvan denemelerinin de azalt\u0131lmas\u0131 hedeflendi.<b><\/b><\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-13922 alignright\" src=\"http:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-3-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" srcset=\"https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-3-300x200.jpg 300w, https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-3-1024x683.jpg 1024w, https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-3-768x512.jpg 768w, https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-3.jpg 1500w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Ege \u00dcniversitesinin sa\u011fl\u0131k alan\u0131nda T\u00fcrkiye\u2019nin referans merkezi oldu\u011funa dikkat \u00e7eken Rekt\u00f6r Prof. Dr. Necdet Budak, \u201c\u00dcniversitemiz, di\u011fer bir\u00e7ok alanda oldu\u011fu gibi sa\u011fl\u0131k hizmetleri alan\u0131nda da \u00fclkemizin referans merkezlerinden birisi. Egeli akademisyenlerimiz taraf\u0131ndan geli\u015ftirilen projelerle, sa\u011fl\u0131kta alternatif bir\u00e7ok tan\u0131 ve tedavi y\u00f6netimi ortaya koyarak, yeni ba\u015far\u0131lara imza atmaya devam ediyoruz. Bu kapsamda Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyemiz Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f taraf\u0131ndan y\u00fcr\u00fct\u00fclen projeyle \u00e7ip \u00fcst\u00fc meme kanseri modeli \u00fcretildi. \u00c7ip \u00fcst\u00fc meme kanseri modeli, potansiyel tedavi edicilerin etkinli\u011finin de\u011ferlendirilmesi i\u00e7in g\u00fc\u00e7l\u00fc bir klinik \u00f6ncesi uygulama alan\u0131 arac\u0131 niteli\u011finde olacak. Ba\u015far\u0131s\u0131 dolay\u0131s\u0131yla Prof. Dr. Ye\u015fil \u00c7elikta\u015f hocam\u0131z\u0131 ve ekibini tebrik ediyorum\u201d diye konu\u015ftu.<\/p>\n<p style=\"text-align: justify;\"><b>\u201cMeme kanseri mekanizmalar\u0131 en iyi \u015fekilde anla\u015f\u0131lmal\u0131\u201d<\/b><\/p>\n<p style=\"text-align: justify;\">Meme kanseri ve ara\u015ft\u0131rma s\u00fcre\u00e7leri hakk\u0131nda bilgi veren Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f, \u201cMeme kanseri, d\u00fcnya \u00e7ap\u0131nda kad\u0131nlar aras\u0131nda en s\u0131k g\u00f6r\u00fclen kanser olmakla birlikte, ne yaz\u0131k ki en \u00e7ok \u00f6l\u00fcme sebep olan kanserlerden de birisi. Pek \u00e7ok farkl\u0131 tipe sahip olan meme kanseri mekanizmalar\u0131 en iyi \u015fekilde anla\u015f\u0131lmal\u0131. \u00c7\u00fcnk\u00fc elde edilecek sonu\u00e7, kansere kar\u015f\u0131 geli\u015ftirilecek olan tedaviyi de belirleyici nitelikte. Meme kanserinin karma\u015f\u0131k mekanizmalar\u0131n\u0131n anla\u015f\u0131lmas\u0131 i\u00e7in ara\u015ft\u0131rman\u0131n in vivo ko\u015fullarda, yani b\u00fct\u00fcn bir organizman\u0131n \u00fczerinde yap\u0131lmas\u0131 gerekir. Normal mekanik, fiziksel ve biyokimyasal i\u015flevlerde ortaya \u00e7\u0131kan bozukluklar\u0131n en do\u011fru \u015fekilde taklit edilmesi ancak h\u00fccre bazl\u0131 sistemlerle m\u00fcmk\u00fcn olur. S\u0131kl\u0131kla kullan\u0131lan 2 boyutlu h\u00fccre k\u00fclt\u00fcrleri h\u00fccreleraras\u0131 ve h\u00fccre-matriks etkile\u015fimleri gibi in vivo ko\u015fullar\u0131 taklit etmekte yetersiz kald\u0131\u011f\u0131 i\u00e7in son zamanlarda 3 boyutlu h\u00fccre k\u00fclt\u00fcrleri ilgi oda\u011f\u0131 oluyor\u201d dedi.<\/p>\n<p style=\"text-align: justify;\">Prof. Dr. Ye\u015fil \u00c7elikta\u015f, \u201cKanser biyolojisinin anla\u015f\u0131lmas\u0131 ve ila\u00e7 geli\u015ftirmeye y\u00f6nelik \u00e7al\u0131\u015fmalarda h\u00fccre k\u00fclt\u00fcr\u00fc \u00e7al\u0131\u015fmalar\u0131n\u0131 takiben ger\u00e7ekle\u015ftirilen hayvan denemelerinin yerini in vivo\u2019ya alternatif sistemler ald\u0131. Bu geli\u015fmede benzerlik, maliyet, zaman, etkinlik, g\u00fcvenlik ve etik prensipler gibi bir\u00e7ok fakt\u00f6r etkili oldu. 2021 tarihli \u2018FDA Modernizasyon Yasas\u0131 (HR 2565)\u2019 da meme kanserine kar\u015f\u0131 geli\u015ftirilecek bir ilac\u0131n etkinli\u011fini ve g\u00fcvenli\u011fini belirlemede hayvan denemelerine alternatif olarak \u00e7ip \u00fcst\u00fc organ sistemleri ve mikrofizyolojik sistemler yenilik\u00e7i bir yakla\u015f\u0131m sundu. Biz de Modernizasyon Yasas\u0131 ile ili\u015fkili olarak \u00fcretti\u011fimiz projemiz kapsam\u0131nda \u00e7ip \u00fcst\u00fc meme kanseri modeli geli\u015ftirdik. Bu model sayesinde meme kanserinin invazyon, intravazasyon gibi farkl\u0131 yay\u0131l\u0131m g\u00f6sterme a\u015famalar\u0131n\u0131n en iyi \u015fekilde taklit edilmesini sa\u011flad\u0131k. B\u00f6ylelikle hayvan denemelerini de m\u00fcmk\u00fcn oldu\u011funca azaltmay\u0131 ama\u00e7lad\u0131k. Ayr\u0131ca geli\u015ftirdi\u011fimiz \u00e7ip \u00fcst\u00fc meme kanseri modeli, potansiyel tedavi edicilerin etkinli\u011finin ve g\u00fcvenli\u011finin de\u011ferlendirilmesi i\u00e7in g\u00fc\u00e7l\u00fc bir klinik \u00f6ncesi uygulama alan\u0131 arac\u0131 niteli\u011fi ta\u015f\u0131yor\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ege \u00dcniversitesi (E\u00dc), nitelikli akademik faaliyetleriyle hem bilim d\u00fcnyas\u0131na hem de insanl\u0131\u011fa katk\u0131 sunmaya devam&#8230;<\/p>\n","protected":false},"author":2,"featured_media":13921,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70],"tags":[],"class_list":["post-13920","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/03\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-2-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"<a href=\"https:\/\/www.euegeajans.com\/index.php\/category\/bilim\/\" rel=\"category tag\">Bilim<\/a> <a href=\"https:\/\/www.euegeajans.com\/index.php\/category\/egitim\/\" rel=\"category tag\">E\u011fitim<\/a> <a href=\"https:\/\/www.euegeajans.com\/index.php\/category\/gncl\/\" rel=\"category tag\">G\u00fcncel<\/a> <a href=\"https:\/\/www.euegeajans.com\/index.php\/category\/kampus\/\" rel=\"category tag\">Kamp\u00fcs<\/a>","tag_info":"Kamp\u00fcs","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=13920"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13920\/revisions"}],"predecessor-version":[{"id":13923,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13920\/revisions\/13923"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/13921"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=13920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=13920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=13920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}