{"id":13592,"date":"2023-01-20T05:16:00","date_gmt":"2023-01-20T05:16:00","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=13592"},"modified":"2023-01-20T07:22:35","modified_gmt":"2023-01-20T07:22:35","slug":"egeli-bilim-insani-doc-dr-evrandan-kan-hastaliklarinin-tedavisine-katki-saglayacak-proje","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2023\/01\/20\/egeli-bilim-insani-doc-dr-evrandan-kan-hastaliklarinin-tedavisine-katki-saglayacak-proje\/","title":{"rendered":"Egeli bilim insan\u0131 Do\u00e7. Dr. Evran\u2019dan, kan hastal\u0131klar\u0131n\u0131n tedavisine katk\u0131 sa\u011flayacak proje<\/strong>
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Ege \u00dcniversitesi (E\u00dc) Fen Fak\u00fcltesi Biyokimya B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Serap Evran\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc \u00fcstlendi\u011fi, uluslararas\u0131 COST aksiyonu \u00e7er\u00e7evesinde T\u00dcB\u0130TAK taraf\u0131ndan desteklenen \u201cHiston Deasetilaz 10 (HDAC10) Aktivitesinin \u0130nhibisyonu \u0130\u00e7in Spesifik DNA Aptamerinin Geli\u015ftirilmesi\u201d projesi \u00e7al\u0131\u015fmalar\u0131 devam ediyor. E\u00dc Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, nitelikli \u00e7al\u0131\u015fmalar\u0131ndan dolay\u0131 Do\u00e7. Dr. Serap Evran\u2019\u0131 ve proje ekibini tebrik ederek ba\u015far\u0131lar diledi.<\/p>\n

Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Fen Fak\u00fcltesi Biyokimya B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Serap Evran\u2019\u0131n yapt\u0131\u011f\u0131 Fen Bilimleri Enstit\u00fcs\u00fc Biyokimya Anabilim Dal\u0131 Doktora \u00d6\u011frencisi Ezgi Man\u2019\u0131n bursiyer olarak g\u00f6rev ald\u0131\u011f\u0131 projede, HDAC10 enzim aktivitesine kar\u015f\u0131 aptamer ad\u0131 verilen, tek iplikli DNA yap\u0131s\u0131nda yeni bir molek\u00fcl\u00fcn geli\u015ftirilmesi \u00e7al\u0131\u015fmalar\u0131 devam ediyor. Proje sonucunda elde edilecek aptamerin potansiyel bir ila\u00e7 aday\u0131 olarak kronik GVHD tedavisi \u00e7al\u0131\u015fmalar\u0131na katk\u0131 yapmas\u0131 hedefleniyor.<\/p>\n

Projenin detaylar\u0131 ile ilgili bilgi veren Do\u00e7. Dr. Serap Evran, \u201cAllojenik hematopoietik k\u00f6k h\u00fccre nakli kemik ili\u011fi yetmezli\u011fi, hemoglobin kaynakl\u0131 kan hastal\u0131klar\u0131 ve talasemi gibi hastal\u0131klar i\u00e7in \u00f6nemli bir tedavi se\u00e7ene\u011fidir.\u00a0 Bunun i\u00e7in aile \u00fcyeleri, aileden olmayan ki\u015filer veya kordon kan\u0131 \u00fcnitelerinden elde edilen h\u00fccreler kullan\u0131lmaktad\u0131r. Bu tedavinin en \u00f6nemli komplikasyonu nakil sonras\u0131nda ortaya \u00e7\u0131kabilen graft versus host (GVHD) hastal\u0131\u011f\u0131d\u0131r. GVHD hastal\u0131\u011f\u0131n\u0131n nedeni, ba\u011f\u0131\u015f\u00e7\u0131n\u0131n beyaz kan h\u00fccrelerinin al\u0131c\u0131 h\u00fccreleri yabanc\u0131 olarak alg\u0131lamas\u0131d\u0131r\u201d diye konu\u015ftu.<\/p>\n

Do\u00e7. Dr. Serap Evran, \u201cGVHD, akut veya kronik formda ortaya \u00e7\u0131kmaktad\u0131r. Akut GVHD\u2019nin \u00f6nlenmesi ve tedavisi ile ilgili geli\u015fmeler olmas\u0131na ra\u011fmen, kronik GVHD pek \u00e7ok hastay\u0131 olumsuz etkilemekte ve \u00f6l\u00fcmlere yol a\u00e7maktad\u0131r. Kronik GVHD tedavisinde ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lay\u0131c\u0131 ila\u00e7lar kullan\u0131lmaktad\u0131r. Ancak, baz\u0131 hastalar\u0131n tedaviye cevap vermemesi ve uzun s\u00fcreli ila\u00e7 kullan\u0131m\u0131n\u0131n neden oldu\u011fu yan etkiler nedeni ile yeni tedavi y\u00f6ntemlerine ihtiya\u00e7 vard\u0131r. Kronik GVHD tedavisinde d\u00fczenleyici T h\u00fccreleri ad\u0131 verilen ve ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini bask\u0131layan h\u00fccrelerin kullan\u0131m\u0131 umut vericidir. Bu h\u00fccrelerin GVHD tedavisinde kullan\u0131labilmesi i\u00e7in, Foxp3 ad\u0131 verilen bir protein gereklidir. Foxp3 proteinin \u00fcretimi i\u00e7in de histon deasetilaz 10 (HDAC10) ad\u0131 verilen enzimin aktivitesini durdurucu yeni ila\u00e7lar gereklidir\u201d dedi.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ege \u00dcniversitesi (E\u00dc) Fen Fak\u00fcltesi Biyokimya B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Serap Evran\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc \u00fcstlendi\u011fi,…<\/p>\n","protected":false},"author":2,"featured_media":13593,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70],"tags":[],"class_list":["post-13592","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Doc.-Dr.-Serap-Evran-Prof.-Dr.-Necdet-Budak-1-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a>","tag_info":"Kamp\u00fcs","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=13592"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13592\/revisions"}],"predecessor-version":[{"id":13594,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13592\/revisions\/13594"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/13593"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=13592"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=13592"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=13592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}