{"id":13551,"date":"2023-01-17T05:10:00","date_gmt":"2023-01-17T05:10:00","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=13551"},"modified":"2023-01-17T07:14:35","modified_gmt":"2023-01-17T07:14:35","slug":"egeli-akademisyenlerden-parkinson-hastaligina-isik-tutacak-proje","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2023\/01\/17\/egeli-akademisyenlerden-parkinson-hastaligina-isik-tutacak-proje\/","title":{"rendered":"Egeli akademisyenlerden Parkinson hastal\u0131\u011f\u0131na \u0131\u015f\u0131k tutacak proje<\/strong>"},"content":{"rendered":"

Gen Susturma (Nakavt) y\u00f6ntemi Parkinson hastal\u0131\u011f\u0131n\u0131n tedavisinde yeni yakla\u015f\u0131mlara katk\u0131 sa\u011flayabilir mi?<\/p>\n

Egeli akademisyenlerden Parkinson hastal\u0131\u011f\u0131na \u0131\u015f\u0131k tutacak proje<\/b><\/p>\n

Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi Histoloji ve Embriyoloji Anabilim Dal\u0131 \u00d6\u011fretim \u00fcyesi Prof. Dr. Altu\u011f Yava\u015fo\u011flu ve ekibinin\u00a0 \u201cDeneysel Parkinson Hastal\u0131\u011f\u0131 Modelinde PCAF Gen Nakavt\u0131n\u0131n N\u00f6rodejenerasyonla \u0130li\u015fkili S\u00fcre\u00e7ler \u00dczerine Etkileri\u201d ba\u015fl\u0131kl\u0131 projesi T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) taraf\u0131ndan Ar-Ge proje \u00e7a\u011fr\u0131s\u0131 kapsam\u0131nda kabul edildi. Proje, Parkinson hastal\u0131\u011f\u0131n\u0131n ortaya \u00e7\u0131k\u0131\u015f\u0131nda etkili molek\u00fcler mekanizmalar\u0131n anla\u015f\u0131lmas\u0131na katk\u0131 sa\u011flayacak.<\/p>\n

Proje ekibini tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201c\u00dcniversitemiz akademisyenleri geli\u015ftirdikleri projelerle topluma fayda sa\u011flamaya devam ediyor.\u00a0 Prof. Dr. Yava\u015fo\u011flu ve ekibinin Parkinson hastal\u0131\u011f\u0131na y\u00f6nelik yapt\u0131klar\u0131 \u00e7al\u0131\u015fmalar bu hastal\u0131\u011f\u0131n nedenlerine \u0131\u015f\u0131k tutacak. Prof. Dr. Yava\u015fo\u011flu ve ekibini tebrik ediyor, \u00e7al\u0131\u015fmalar\u0131nda ba\u015far\u0131lar diliyorum\u201d dedi.<\/p>\n

D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fcn\u00fcn 2022 verilerine g\u00f6re d\u00fcnya genelinde yakla\u015f\u0131k 8,5 milyon ki\u015finin Parkinson hastal\u0131\u011f\u0131ndan etkilendi\u011fini ifade eden Prof. Dr. Yava\u015fo\u011flu, \u201cParkinson hastal\u0131\u011f\u0131, hareketlerde yava\u015flama, el ve ayaklarda istemsiz titreme, v\u00fccudun hafif\u00e7e \u00f6ne do\u011fru e\u011filmesi gibi semptomlarla kendini belli eden n\u00f6rodejeneratif bir hastal\u0131kt\u0131r. Beynin substantia nigra (siyah \u00e7ekirdek) olarak isimlendirilen b\u00f6lgesindeki dopamin \u00fcretiminden sorumlu h\u00fccrelerin kayb\u0131na ba\u011fl\u0131 olarak ortaya \u00e7\u0131kan bu hastal\u0131k \u00fczerine yap\u0131lan \u00e7al\u0131\u015fmalar, ya\u015f ve genetik fakt\u00f6rlerin yan\u0131 s\u0131ra tar\u0131m ila\u00e7lar\u0131 gibi \u00e7evresel etmenlerin Parkinson hastal\u0131\u011f\u0131 ile yak\u0131ndan ili\u015fkili oldu\u011funa dikkat \u00e7ekmektedir. \u00d6te yandan Parkinson Hastal\u0131\u011f\u0131nda g\u00f6r\u00fclen bu h\u00fccresel kay\u0131plar\u0131n molek\u00fcler mekanizmalar\u0131 g\u00fcn\u00fcm\u00fczde dahi hala tam anlam\u0131yla ayd\u0131nlat\u0131lamam\u0131\u015ft\u0131r\u201d dedi.<\/p>\n

\u201cKlinik ve klinik \u00f6ncesi ara\u015ft\u0131rmalara katk\u0131 sa\u011flayacak\u201d<\/b><\/p>\n

Hastal\u0131k \u00fczerinde yap\u0131lacak klinik ve klinik \u00f6ncesi ara\u015ft\u0131rmalardan elde edilecek yeni verilerin \u00f6nemli oldu\u011funu vurgulayan Prof. Dr. Yava\u015fo\u011flu, \u201cParkinson hastal\u0131\u011f\u0131n\u0131n ortaya \u00e7\u0131k\u0131\u015f\u0131nda etkili mekanizmalar\u0131n daha iyi anla\u015f\u0131lmas\u0131 ve tedavisinde yeni yakla\u015f\u0131mlar\u0131n tan\u0131mlanmas\u0131 olduk\u00e7a \u00f6nem ta\u015f\u0131maktad\u0131r. Bu ba\u011flamda tasarlam\u0131\u015f oldu\u011fumuz ve Ege \u00dcniversitesi Bilimsel Ara\u015ft\u0131rma Projeleri Koordinat\u00f6rl\u00fc\u011f\u00fc taraf\u0131ndan desteklenen \u00d6NAP projemiz kapsam\u0131nda, h\u00fccre i\u00e7erisinde i\u015flevini yitirmi\u015f proteinlerin y\u0131k\u0131m\u0131ndan sorumlu molek\u00fcler mekanizmalar\u0131n d\u00fczenlenmesinde g\u00f6rev alan BRCC3 ve mitokondrial homeostazdan sorumlu GCN5 genlerinin nakavt\u0131n\u0131n Parkinson Hastal\u0131\u011f\u0131 \u00fczerine etkilerini ara\u015ft\u0131rmay\u0131 ama\u00e7lad\u0131k. \u015eu an daha ba\u015flang\u0131\u00e7 a\u015famas\u0131nda olan projemizin ilerleyen a\u015famalar\u0131nda elde edece\u011fimiz veriler ve bu verilerin payla\u015f\u0131laca\u011f\u0131 bilimsel makaleler ile Parkinson hastal\u0131\u011f\u0131n\u0131n ortaya \u00e7\u0131k\u0131\u015f\u0131nda etkili molek\u00fcler mekanizmalar\u0131n anla\u015f\u0131lmas\u0131na katk\u0131 sa\u011flamay\u0131 hedefliyoruz. Buna ek olarak, \u00e7al\u0131\u015fmam\u0131z\u0131n ilerleyen d\u00f6nemlerde preklinik ve klinik faz \u00e7al\u0131\u015fma a\u015famalar\u0131na ge\u00e7mesi ve bu a\u015famalarda olumlu sonu\u00e7lar elde edilmesi ile\u00a0hastal\u0131\u011f\u0131n tedavisinde yeni yakla\u015f\u0131mlara katk\u0131 sa\u011flayabilmek\u00a0ise bir di\u011fer hedefimizdir\u201d diye konu\u015ftu.<\/p>\n

Prof. Dr. Yava\u015fo\u011flu, \u201cBu \u00e7er\u00e7evede \u00e7al\u0131\u015fmalar\u0131m\u0131za devam ederken, ba\u015fvurusunu yapm\u0131\u015f oldu\u011fumuz benzer bir projemiz de T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 taraf\u0131ndan B Grubu Ar-Ge proje \u00e7a\u011fr\u0131s\u0131 kapsam\u0131nda kabul edildi. Bu \u00e7al\u0131\u015fmam\u0131zda ise n\u00f6ronlarda inflamasyon ve programlanm\u0131\u015f h\u00fccre \u00f6l\u00fcm\u00fc gibi biyolojik s\u00fcre\u00e7lerin reg\u00fclasyonunda rol oynad\u0131\u011f\u0131 bilinen PCAF gen nakavt\u0131n\u0131n Parkinson hastal\u0131\u011f\u0131n\u0131n ortaya \u00e7\u0131k\u0131\u015f\u0131na neden olan molek\u00fcler mekanizmalar \u00fczerine etkilerinin incelenmesini ama\u00e7lad\u0131k. Parkinson hastal\u0131\u011f\u0131n\u0131n etiyolojisi ve tedavisinde yeni terap\u00f6tik hedeflerin tan\u0131mlanmas\u0131n\u0131 ama\u00e7lad\u0131\u011f\u0131m\u0131z bu \u00e7al\u0131\u015fmalar\u0131m\u0131zda bizden desteklerini esirgemeyen Ege \u00dcniversitesi Bilimsel Ara\u015ft\u0131rma Projeleri Koordinat\u00f6rl\u00fc\u011f\u00fc\u2019ne ve T\u00dcSEB\u2019e \u015f\u00fckranlar\u0131m\u0131z\u0131 sunuyoruz\u201d dedi.<\/p>\n

Proje ekibinde Prof. Dr. Nefise \u00dclk\u00fc Karabay Yava\u015fo\u011flu, Do\u00e7. Dr. Fatih Oltulu, Do\u00e7. Dr. \u00c7\u0131\u011f\u0131r Biray Avc\u0131, Do\u00e7. Dr. Nur Selvi G\u00fcnel, Ara\u015f. G\u00f6r. \u00c7evik G\u00fcrel, doktora \u00f6\u011frencileri Aylin Buhur, G\u00f6k\u00e7e Ceren Ku\u015f\u00e7u ve Ebru \u015eanc\u0131 yer al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"

Gen Susturma (Nakavt) y\u00f6ntemi Parkinson hastal\u0131\u011f\u0131n\u0131n tedavisinde yeni yakla\u015f\u0131mlara katk\u0131 sa\u011flayabilir mi? Egeli akademisyenlerden Parkinson…<\/p>\n","protected":false},"author":2,"featured_media":13552,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1],"tags":[],"class_list":["post-13551","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Altug-Yavasoglu-ve-ekibi-2-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a>","tag_info":"G\u00fcncel","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=13551"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13551\/revisions"}],"predecessor-version":[{"id":13553,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13551\/revisions\/13553"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/13552"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=13551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=13551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=13551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}