{"id":13305,"date":"2023-01-05T06:55:40","date_gmt":"2023-01-05T06:55:40","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=13305"},"modified":"2023-01-05T06:55:41","modified_gmt":"2023-01-05T06:55:41","slug":"egeli-bilim-ekibinden-akciger-kanserinin-tedavisine-yonelik-proje","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2023\/01\/05\/egeli-bilim-ekibinden-akciger-kanserinin-tedavisine-yonelik-proje\/","title":{"rendered":"Egeli bilim ekibinden akci\u011fer kanserinin tedavisine y\u00f6nelik proje<\/strong>"},"content":{"rendered":"

Ege \u00dcniversitesi M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131, \u201cK\u00fc\u00e7\u00fck h\u00fccreli d\u0131\u015f\u0131 akci\u011fer kanserine kar\u015f\u0131 CAR T h\u00fccre tedavisi i\u00e7in alternatif hedef antijen havuzunun tek h\u00fccre genomik verileri ile zenginle\u015ftirilmesi\u201d konu proje, T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu (T\u00dcB\u0130TAK) Ara\u015ft\u0131rma Destek Birimi (ARDEB) Kariyer Geli\u015ftirme Program\u0131 kapsam\u0131nda desteklenmeye uygun bulundu.<\/p>\n

Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, ba\u015far\u0131s\u0131ndan \u00f6t\u00fcr\u00fc Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz\u2019\u0131 tebrik etti. Prof. Dr. Budak, \u201cEge \u00dcniversitesi olarak T\u00dcB\u0130TAK\u2019a en \u00e7ok proje veren ve projesi en \u00e7ok kabul g\u00f6ren \u00fcniversitelerin ba\u015f\u0131nda geliyoruz. \u00dcniversitemizde hayata ge\u00e7irdi\u011fimiz Ar-Ge, inovasyon ve ara\u015ft\u0131rma iklimi ile birlikte projelerimiz hem nitelik hem de nicelik olarak art\u0131\u015f g\u00f6sterdi. Hocam\u0131z\u0131 ve proje ekibini tebrik ediyor, ba\u015far\u0131lar\u0131n\u0131n devam\u0131n\u0131 diliyorum\u201d diye konu\u015ftu<\/p>\n

Proje ile ilgili bilgi veren Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz, \u201cK\u00fc\u00e7\u00fck h\u00fccreli d\u0131\u015f\u0131 akci\u011fer kanseri (KHDAK) i\u00e7in FDA onayl\u0131 CAR T h\u00fccre tedavisi hen\u00fcz mevcut de\u011fildir. Bunun en \u00f6nemli nedenlerinden birisi mevcut t\u00fcm\u00f6r antijenlerinin d\u00fc\u015f\u00fck \u00f6zg\u00fcnl\u00fckleri ve ortaya \u00e7\u0131kan y\u00fcksek yan etkileridir. Bu nedenle yeni hedef antijenlerin belirlenmesi ve aday havuzunun geni\u015fletilmesine y\u00f6nelik \u00e7abalar\u0131n art\u0131r\u0131lmas\u0131 KHDAK i\u00e7in de imm\u00fcno-terapi kap\u0131lar\u0131n\u0131 aralayacakt\u0131r\u201d diye konu\u015ftu.<\/p>\n

Projenin benzeri \u00e7al\u0131\u015fmalardan ay\u0131ran yanlar\u0131n\u0131 anlatan Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz, \u201cProjemiz, mevcut tek h\u00fccre transkriptom verilerini yeniden i\u015fleyerek, CAR T h\u00fccre tedavisi i\u00e7in aday antijen se\u00e7iminde bir paradigma de\u011fi\u015fikli\u011fine katk\u0131da bulunacak. Biyoinformatik analizlerle adayl\u0131k potansiyeli belirlenen yeni KHDAK antijenlerin \u00f6zg\u00fcnl\u00fc\u011f\u00fc kanser hastalar\u0131n\u0131n akci\u011fer t\u00fcm\u00f6r ve sa\u011fl\u0131kl\u0131 doku \u00f6rneklerinde ortaya koyulacak ve muhtemel klinik \u00e7al\u0131\u015fmalara kap\u0131 aralayacak. CAR T h\u00fccre tedavisi i\u00e7in saptanmas\u0131 hedeflenen t\u00fcm\u00f6r antijenleri y\u00fczey proteinleri olaca\u011f\u0131 i\u00e7in invaziv olmayan te\u015fhis y\u00f6ntemlerinden kanda likit biyopsi gibi uygulamalara bilimsel temel olu\u015fturacak. \u00a0Tek h\u00fccre sekanslama ve meta verilerini kullanan benzersiz bilgi madencili\u011fi yakla\u015f\u0131m\u0131m\u0131z mevcut tedavilerin kapsam\u0131n\u0131 di\u011fer maligniteler i\u00e7in de geni\u015fletmeye yard\u0131mc\u0131 olacak\u201d dedi.<\/p>\n

\u201cT\u00fcm\u00f6re \u00f6zg\u00fcn antijenler ke\u015ffedilecek\u201d<\/b><\/p>\n

\"\"\u0130lerleyen analitik ve molek\u00fcler tekniklerin \u00fcr\u00fcn\u00fc tek h\u00fccre sekanslama verileri do\u011fru biyoinformatik yakla\u015f\u0131mlarla yeniden i\u015flenerek daha \u00f6nce belirlenmeyen t\u00fcm\u00f6re \u00f6zg\u00fc antijenlerin ke\u015ffedilmesine ve yeni terap\u00f6tik uygulamalara olanak sa\u011flayabilece\u011fini vurgulayan Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz, \u201cProjenin amac\u0131, KHDAK\u2019\u0131n CAR T h\u00fccreleri ile hedeflenebilmesi i\u00e7in yeni t\u00fcm\u00f6r antijenlerinin ke\u015ffine olanak sa\u011flayan bir bilgi \u00fcretim hatt\u0131 olu\u015fturmakt\u0131r. Amaca ula\u015fmak i\u00e7in hedef antijen havuzunun tek h\u00fccre sekanslama verileri ile geni\u015fletilmesi ve aday antijenlerin etkinliklerinin deneysel validasyonlar\u0131n\u0131n ger\u00e7ekle\u015ftirilmesi hedeflenmektedir. Bu proje y\u00f6ntemleri \u00a0biyoinformatik tekniklerle veri zenginle\u015ftirme ve aday antijenlerin tespiti, \u00a0se\u00e7ilen antijenlerin akci\u011fer kanseri klinik t\u00fcm\u00f6r \u00f6rnekleri ve normal dokular \u00fczerinde imm\u00fcnohistokimya ile etkinliklerinin belirlenmesinden olu\u015fmaktad\u0131r\u201d diye konu\u015ftu.<\/p>\n

Y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz\u2019\u0131n yapt\u0131\u011f\u0131, multidispliner i\u015f birli\u011fi ile s\u00fcrd\u00fcr\u00fclen projede; ara\u015ft\u0131rmac\u0131 olarak Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi \u00f6\u011fretim \u00fcyeleri Do\u00e7. Dr. Ay\u015fe Caner ve Do\u00e7. Dr. \u0130lker Ak\u00e7am, proje dan\u0131\u015fman\u0131 olarak T\u0131p Fak\u00fcltesi \u00f6\u011fretim \u00fcyeleri Prof. Dr. Ali Veral ve \u00a0Prof. Dr. Kutsal Turhan ile\u00a0 M\u00fchendislik Fak\u00fcltesi Bilgisayar M\u00fchendisli\u011fi B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi \u00a0Do\u00e7. Dr. Hasan Bulut g\u00f6rev al\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ege \u00dcniversitesi M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131, \u201cK\u00fc\u00e7\u00fck h\u00fccreli…<\/p>\n","protected":false},"author":2,"featured_media":13306,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-13305","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7.jpg",1329,1593,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-250x300.jpg",250,300,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-768x921.jpg",640,768,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-854x1024.jpg",640,767,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-1281x1536.jpg",1281,1536,true],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7.jpg",1329,1593,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-1024x1227.jpg",1024,1227,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2023\/01\/Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=13305"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13305\/revisions"}],"predecessor-version":[{"id":13308,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/13305\/revisions\/13308"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/13306"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=13305"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=13305"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=13305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}