{"id":12777,"date":"2022-12-15T06:05:00","date_gmt":"2022-12-15T06:05:00","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=12777"},"modified":"2022-12-15T08:23:48","modified_gmt":"2022-12-15T08:23:48","slug":"egeli-bilim-insani-dr-ogretim-uyesi-yasin-kaymazin-ar-ge-projesine-tusebden-destek","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2022\/12\/15\/egeli-bilim-insani-dr-ogretim-uyesi-yasin-kaymazin-ar-ge-projesine-tusebden-destek\/","title":{"rendered":"Egeli bilim insan\u0131 Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz\u2019\u0131n Ar-ge projesine T\u00dcSEB\u2019den destek<\/strong>"},"content":{"rendered":"

Ege \u00dcniversitesi M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131, Hacettepe \u00dcniversitesi \u00f6\u011fretim \u00fcyesi Prof. Dr. G\u00fcne\u015f Esenda\u011fl\u0131, Ege \u00dcniversitesi \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Ay\u015fe Caner, Antalya Bilim \u00dcniversitesi \u00f6\u011fretim \u00fcyesi Do\u00e7. Dr. Hilal Kazan\u2019\u0131n ara\u015ft\u0131rmac\u0131 olarak yer ald\u0131\u011f\u0131 \u201cTu\u0308mo\u0308rle ilis\u0327kili makrofajlar\u0131n plastisitelerinde alternatif transkript izoformlar\u0131n\u0131n biyobelirtec\u0327 o\u0308zelliklerinin tek hu\u0308cre RNA sekanslama yaklas\u0327\u0131m\u0131 ile aras\u0327t\u0131r\u0131lmas\u0131\u2019 ba\u015fl\u0131kl\u0131 proje,\u00a0 T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (TU\u0308SEB) Ara\u015ft\u0131rma ve Geli\u015ftirme Projelerini\u0307 Destekleme Program\u0131 kapsam\u0131nda destek ald\u0131.<\/p>\n

Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u00fcretken bilim insan\u0131 Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz\u2019\u0131 tebrik ederek ba\u015far\u0131lar diledi.<\/p>\n

Proje ile ilgili bilgi veren Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz, \u201cDokular\u0131n homeostaz\u0131n\u0131 sag\u0306lama, patojenlere kars\u0327\u0131 savunma ve doku zedelenmesi sonras\u0131 iyiles\u0327mede rol almalar\u0131yla bilinen makrofajlar polarize alt gruplar\u0131 t\u00fcm\u00f6r dokusu i\u00e7ine infiltre olarak da t\u00fcm\u00f6r\u00fc destekleyici ya da \u00f6nleyici roller alabilmektedirler. Bu farkl\u0131las\u0327m\u0131s\u0327 rolleri tetikleyen veya fonksiyonlar aras\u0131 ge\u00e7is\u0327genlig\u0306i sa\u011flayan temel molek\u00fcler mekanizmalar hen\u00fcz tamamen a\u00e7\u0131kl\u0131k kazanmam\u0131\u015ft\u0131r. Makrofajlar\u0131n fonksiyonel olarak \u00f6zelles\u0327meleri ile micro RNAlar\u0131n ilis\u0327kili bulunmas\u0131 3\u2019-UTR \u00fczerinden reg\u00fclasyonlar\u0131n varl\u0131g\u0306\u0131n\u0131 is\u0327aret etmekte ve alternatif poliadenilasyon ile olus\u0327an transkript izoformlar\u0131n\u0131n tespit edilmesinin \u00f6nemi vurgulamaktad\u0131r. Tek h\u00fccre RNA sekanslama teknolojilerinin ilerlemesi ile birlikle bu ili\u015fkilerin molek\u00fcler nedenleri doku g\u00fcr\u00fclt\u00fcs\u00fcnden uzakla\u015fm\u0131\u015f\u0327, benzer genetik programa sahip h\u00fccre t\u00fcrleri \u00fczerinde ara\u015ft\u0131r\u0131lma imk\u00e2n\u0131 bulmaktad\u0131r. Bu proje makrofaj polarizasyonu ile ba\u015fkala\u015fan fonksiyonel alt h\u00fccre gruplar\u0131na \u00f6zg\u00fc alternatif poliadenilasyon profillerinin tespit edilmesi ve bu \u00f6zelle\u015fmi\u015f\u0327 gruplar\u0131n t\u00fcm\u00f6r mikro \u00e7evresindeki da\u011f\u0131l\u0131m\u0131n\u0131n belirlenmesini ama\u00e7lamaktad\u0131r\u201d diye konu\u015ftu.<\/p>\n

Ara\u015ft\u0131rman\u0131n hedeflerinden bahseden Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz, \u201cTek h\u00fccre sekanslama verilerinden alternatif poliadenilasyon verileri a\u00e7\u0131s\u0131ndan ele alabilen biyoinformatik analiz algoritmalar\u0131 geli\u015ftirmektir.\u00a0 Geli\u015ftirilecek modellerde referans verisi olarak kullan\u0131lmak \u00fczere makrofaj polarizasyonu deneyleri ger\u00e7ekle\u015ftirmektir.\u00a0 K\u00fc\u00e7\u00fck h\u00fccreli d\u0131\u015f\u0131 akci\u011fer kanseri t\u00fcm\u00f6r mikro \u00e7evresinde t\u00fcm\u00f6rle ili\u015fkili makrofajlar\u0131n \u00f6zelle\u015fmi\u015f\u0327 alt gruplar\u0131nda biyobelirte\u00e7 olma potansiyelindeki transkript farkl\u0131la\u015fmalar\u0131n\u0131 incelemektir \u201ddedi.<\/p>\n

Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz, \u201cBu \u00e7al\u0131\u015fmada planlanan tek h\u00fccre sekanslama verilerini \u00f6zelle\u015fmi\u015f\u0327 alt makrofaj gruplar\u0131n\u0131n karakterizasyonu amac\u0131yla farkl\u0131 bir bak\u0131s\u0327 a\u00e7\u0131s\u0131 ile biyoinformatik a\u00e7\u0131dan is\u0327leme projenin \u00f6zg\u00fcn yakla\u015f\u0131m\u0131d\u0131r. Global transkriptom \u00f6l\u00e7ekte \u00f6zelles\u0327mis\u0327 makrofaj alt gruplar\u0131n\u0131n UTR uzunlu\u011fu de\u011fi\u015fimleri ile potansiyel mikro RNA temelli reg\u00fclasyonlar aras\u0131nda ili\u015fki kurulmas\u0131 a\u00e7\u0131s\u0131 \u00e7al\u0131\u015fman\u0131n bir di\u011fer \u00f6zg\u00fcn de\u011feridir. Ayr\u0131ca makrofaj polarizasyonu akabinde \u00fcretilecek tek h\u00fccre RNA sekans verileri TAM\u2019lar\u0131n ayd\u0131nlat\u0131lmas\u0131nda bir referans modeli olarak kullan\u0131lacak olmas\u0131 projenin \u00f6nemli bir \u00f6zg\u00fcn yakla\u015f\u0131m\u0131d\u0131r. Bu proje ile t\u00fcm\u00f6rle ili\u015fkili makrofajlar\u0131n alt gruplar\u0131n\u0131n biyomark\u00f6rleri olma potansiyelinde transkriptomik farkl\u0131l\u0131klar\u0131n tek h\u00fccre sekanslama verileri ile elde edilme imk\u00e2n\u0131 sag\u0306lanmaktad\u0131r. Biyoinformatik algoritma geli\u015ftirme s\u00fcreci, kontroll\u00fc deney ile referans verisi \u00fcretimi, h\u00fccre alt gruplar\u0131n\u0131 belirleyen model geli\u015ftirilmesi ve geli\u015ftirilen modelin t\u00fcm\u00f6r biyopsi \u00f6rne\u011finde test edilmesi seklinde 4 ana safhadan olu\u015fan proje 9 is\u0327 paketi i\u00e7ermektedir. 24 ay i\u00e7inde tamamlanmas\u0131 planlanan bu proje \u00e7e\u015fitli a\u015famalar\u0131nda Ege \u00dcniversitesi, Hacettepe \u00dcniversitesi ve Antalya Bilim \u00dcniversitesi is\u0327 birlig\u0306i sayesinde ger\u00e7ekle\u015ftirilecek olup olduk\u00e7a interdisipliner alanlar\u0131n (biyoinformatik, bilgisayar m\u00fchendislig\u0306i, imm\u00fcnoloji, molek\u00fcler onkoloji) etkile\u015fimi ve akademik \u00fcretkenlig\u0306ini art\u0131racakt\u0131r. Son teknoloji molek\u00fcler tekniklerden tek h\u00fccre RNA sekanslama y\u00f6ntemlerinin en d\u00fcs\u0327\u00fck maliyetli ve y\u00fcksek verimlilikte bir metodunu \u00fclkemizde ilk defa uygulama f\u0131rsat\u0131 verecek bu proje bu y\u00f6n\u00fcyle de teknoloji transferi imk\u00e2n\u0131 sunma potansiyeliyle ve \u00fclkemize hem ekonomik hem de akademik a\u00e7\u0131dan b\u00fcy\u00fck katk\u0131lar sa\u011flayacakt\u0131r. Ayr\u0131ca projenin biyoinformatik geli\u015ftirme ve laboratuvar deneyimlerinde aktif rol alacak lisans\u00fcst\u00fc ve doktora \u00f6\u011frencilerini yeti\u015ftirme y\u00f6n\u00fcyle de akademiye katk\u0131s\u0131 olacakt\u0131r\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ege \u00dcniversitesi M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc Dr. \u00d6\u011fretim \u00dcyesi Yasin Kaymaz\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131, Hacettepe \u00dcniversitesi…<\/p>\n","protected":false},"author":2,"featured_media":12779,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70],"tags":[],"class_list":["post-12777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-scaled.jpg",2136,2560,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-250x300.jpg",250,300,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-768x920.jpg",640,767,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-855x1024.jpg",640,767,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-1282x1536.jpg",1282,1536,true],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-1709x2048.jpg",1709,2048,true],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-1024x1227.jpg",1024,1227,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/Duzenlenmis_Prof.-Dr.-Necdet-Budak-Dr.-Ogretim-Uyesi-Yasin-Kaymaz-7-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a>","tag_info":"Kamp\u00fcs","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/12777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=12777"}],"version-history":[{"count":2,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/12777\/revisions"}],"predecessor-version":[{"id":12780,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/12777\/revisions\/12780"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/12779"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=12777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=12777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=12777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}