{"id":12380,"date":"2022-12-05T06:46:01","date_gmt":"2022-12-05T06:46:01","guid":{"rendered":"https:\/\/www.euegeajans.com\/?p=12380"},"modified":"2022-12-05T06:46:02","modified_gmt":"2022-12-05T06:46:02","slug":"rett-sendromu-tedavisi-icin-yeni-ilac-denemelerinin-yapilabilecegi-bir-test-modeline-yonelik-onemli-proje","status":"publish","type":"post","link":"https:\/\/www.euegeajans.com\/index.php\/2022\/12\/05\/rett-sendromu-tedavisi-icin-yeni-ilac-denemelerinin-yapilabilecegi-bir-test-modeline-yonelik-onemli-proje\/","title":{"rendered":"Rett sendromu tedavisi i\u00e7in yeni ila\u00e7 denemelerinin yap\u0131labilece\u011fi bir test modeline y\u00f6nelik \u00f6nemli proje…<\/strong>"},"content":{"rendered":"

Ege \u00dcniversitesinin bir projesi daha T\u00dcB\u0130TAK taraf\u0131ndan desteklendi<\/p>\n

Rett sendromu tedavisi i\u00e7in yeni ila\u00e7 denemelerinin yap\u0131labilece\u011fi bir test modeline y\u00f6nelik \u00f6nemli proje…<\/b><\/p>\n

Ege \u00dcniversitesi (E\u00dc), ulusal ve uluslararas\u0131 arenada ba\u015far\u0131lar\u0131yla ad\u0131n\u0131 duyuran akademisyenlerince y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fmalarla T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu (T\u00dcB\u0130TAK) taraf\u0131ndan desteklenen projelerinin birini daha ba\u015far\u0131yla tamaml\u0131yor. E\u00dc M\u00fchendislik Fak\u00fcltesi Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc \u00f6\u011fretim \u00fcyesi Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f\u2019\u0131n y\u00fcr\u00fctt\u00fc\u011f\u00fc \u201cIn Vitro \u00dc\u00e7 Boyutlu Serebral Organoid K\u00fclt\u00fcr Temelli \u00c7ip \u00dcst\u00fc Rett Sendromu (RTT) Modelinin Geli\u015ftirilmesi\u201d projesi T\u00dcB\u0130TAK \u201c1001 – Bilimsel ve Teknolojik Ara\u015ft\u0131rma Projelerini Destekleme Program\u0131\u201d kapsam\u0131nda desteklendi. Projede nadir hastal\u0131k olan Rett Sendromunun tedavisine y\u00f6nelik hastal\u0131\u011f\u0131n \u00e7ip \u00fcst\u00fc modeli geli\u015ftirildi.<\/p>\n

\"\"Egeli akademisyenlerin projelerinin ald\u0131\u011f\u0131 desteklerin motivasyonlar\u0131n\u0131 art\u0131rd\u0131\u011f\u0131n\u0131 ifade eden E\u00dc Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak, \u201cBilim \u00fcretme ekosistemimiz neticesinde ger\u00e7ekle\u015ftirdi\u011fimiz ara\u015ft\u0131rma projelerimizle T\u00dcB\u0130TAK nezdindeki ba\u015far\u0131m\u0131z\u0131 her ge\u00e7en g\u00fcn katlayarak art\u0131r\u0131yoruz. Ege \u00dcniversitesi olarak, en \u00e7ok proje \u00fcreten ve projesi T\u00dcB\u0130TAK taraf\u0131ndan en \u00e7ok kabul edilen \u00fcniversiteler aras\u0131nda zirvede yer al\u0131yoruz. \u00dcretken akademisyenlerimizin y\u00fcr\u00fctt\u00fc\u011f\u00fc projeleri i\u00e7in ald\u0131\u011f\u0131 destekler, bizlerin de motivasyonunu art\u0131r\u0131yor. Biyom\u00fchendislik B\u00f6l\u00fcm\u00fc Hocam\u0131z Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 Rett Sendromunun tedavisine y\u00f6nelik \u00e7ip \u00fcst\u00fc modeli geli\u015ftirilmesini ama\u00e7layan ve T\u00dcB\u0130TAK taraf\u0131ndan desteklenen proje tamamlanmak \u00fczere. Olduk\u00e7a verimli kazan\u0131mlar elde edilen bu proje dolay\u0131s\u0131yla Prof. Dr. Ye\u015fil \u00c7elikta\u015f hocam\u0131z\u0131 ve ekibini tebrik ediyorum\u201d dedi.<\/p>\n

\u201c\u00c7ip \u00fcst\u00fc Rett Sendromu hastal\u0131\u011f\u0131 modeli geli\u015ftirece\u011fiz\u201d<\/b><\/p>\n

\"\"Proje kapsam\u0131nda Rett Sendromunun \u00e7ip \u00fcst\u00fc organ sistemleri ile modellenmesini hedeflediklerini belirten Prof. Dr. \u00d6zlem Ye\u015fil \u00c7elikta\u015f, \u201cCRISPR\/Cas9 genom d\u00fczenleme teknolojisi kullan\u0131larak ind\u00fcklenmi\u015f pluripotent k\u00f6k h\u00fccrelerde mutasyon olu\u015fturularak 3 boyutlu serebral organoid k\u00fclt\u00fcr temelli \u00e7ip \u00fcst\u00fc Rett Sendromu hastal\u0131\u011f\u0131 modeli geli\u015ftirdik. RTT, genetik nadir hastal\u0131klar kapsam\u0131nda de\u011ferlendirilen ve \u00e7o\u011funlukla k\u0131z \u00e7ocuklar\u0131n\u0131 etkileyen bir n\u00f6rogeli\u015fimsel bozukluk. Bu nadir hastal\u0131\u011f\u0131n tedavisine y\u00f6nelik bir\u00e7ok terap\u00f6tik strateji geli\u015ftirilmesine ra\u011fmen, hen\u00fcz etkin bir tedavisi bulunmuyor. Bu kapsamda geli\u015ftirilen potansiyel yeni ila\u00e7lar\u0131n g\u00fcvenli\u011fini ve etkinli\u011fini ara\u015ft\u0131rmak i\u00e7in kullan\u0131lan deney hayvan modellerinde insan patofizyoanatomisinin \u00e7ok iyi taklit edilememesi, geli\u015ftirilen ila\u00e7lar\u0131n klinik \u00e7al\u0131\u015fmalarda ba\u015far\u0131s\u0131zl\u0131kla sonu\u00e7lanmas\u0131na neden oluyor. Ayn\u0131 zamanda hayvan modellerinin kullan\u0131m\u0131 beraberinde etik kayg\u0131lar\u0131 da getiriyor\u201d dedi.<\/p>\n

Projenin i\u015fleyi\u015fini anlatan Prof. Dr. Ye\u015fil \u00c7elikta\u015f, \u201c2021 y\u0131l\u0131nda \u00e7\u0131kar\u0131lan yasa ile alternatif test y\u00f6ntemlerinden klinik olmayan ve test \u00e7al\u0131\u015fmalar\u0131 kapsam\u0131nda h\u00fccre bazl\u0131 testlerinin yan\u0131 s\u0131ra organ \u00e7ipleri ve mikrofizyolojik sistemlerinde ilac\u0131n g\u00fcvenirli\u011finin ve etkinli\u011finin ara\u015ft\u0131r\u0131lmas\u0131nda kullan\u0131labilirli\u011fi sa\u011fland\u0131. Bu bak\u0131mdan bizim projede kulland\u0131\u011f\u0131m\u0131z y\u00f6ntem de bu yasal d\u00fczenlemeyle uyumlu. Projemiz kapsam\u0131nda, insan kaynakl\u0131 h\u00fccrelerin kullan\u0131m\u0131na izin vererek, ind\u00fcklenmi\u015f pluripotent k\u00f6k h\u00fccrelerden geli\u015ftirilen 3 boyutlu serebral organoidleri i\u00e7eren ve b\u00f6ylece Rett Sendromunu yak\u0131ndan taklit edebilen bir \u2018\u00c7ip \u00dcst\u00fc Rett Sendromu Modeli\u2019 geli\u015ftirdik. Nadir hastal\u0131k kapsam\u0131nda de\u011ferlendirilen ve hen\u00fcz tedavisi olmay\u0131p \u00e7al\u0131\u015fmalara devam edilen Rett sendromu kapsam\u0131nda yeni ila\u00e7 denemelerinin ger\u00e7ekle\u015ftirilebilece\u011fi bir alternatif test modeli olarak klinik \u00f6ncesi \u00e7al\u0131\u015fmalarda geli\u015ftirilen platformun kullan\u0131labilirli\u011fi de yasayla destekleniyor\u201d diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ege \u00dcniversitesinin bir projesi daha T\u00dcB\u0130TAK taraf\u0131ndan desteklendi Rett sendromu tedavisi i\u00e7in yeni ila\u00e7 denemelerinin…<\/p>\n","protected":false},"author":2,"featured_media":12381,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-12380","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1.jpg",1500,1000,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1-768x512.jpg",640,427,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1-1024x683.jpg",640,427,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1.jpg",1500,1000,false],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1.jpg",1500,1000,false],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1-1024x683.jpg",1024,683,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/12\/EGE-NECDET-BUDAK-OZLEM-YESIL-CELIKTAS-1-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/12380","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=12380"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/12380\/revisions"}],"predecessor-version":[{"id":12384,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/12380\/revisions\/12384"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/12381"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=12380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=12380"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=12380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}