Klozapin\u2019in kardiyotoksik etki mekanizmas\u0131n\u0131 ayd\u0131nlatmaya d\u00f6n\u00fck ilk \u00e7al\u0131\u015fma<\/p>\n
Egeli akademisyenin makalesine uluslararas\u0131 ilgi<\/b><\/p>\n
D\u00fcnyaca bilinen Taylor&Francis yay\u0131nevi taraf\u0131ndan yay\u0131mlanan \u201cDrug Metabolism Reviews\u201d dergisinin A\u011fustos 2022 say\u0131s\u0131nda, \u0130ngiltere ve ABD \u00fcniversite ve ila\u00e7 firmalar\u0131n\u0131n Ar-Ge b\u00f6l\u00fcmlerinden toplam 14 bilim insan\u0131, 2021 y\u0131l\u0131nda t\u00fcm d\u00fcnyada yay\u0131nlanm\u0131\u015f biyoaktivasyon ve reaktivite \u00e7al\u0131\u015fmalar\u0131n\u0131n incelendi\u011fi bir de\u011ferlendirme makalesi yay\u0131nlad\u0131. De\u011ferlendirmeye al\u0131nan 14 uluslararas\u0131 \u00e7al\u0131\u015fmadan birisi de Ege \u00dcniversitesi Eczac\u0131l\u0131k Fak\u00fcltesi Farmas\u00f6tik Toksikoloji Anabilim Dal\u0131 \u00f6\u011fretim \u00fcyesi Prof. Dr. Hilmi Orhan ve ekibinin 2021 tarihli klozapin\u2019in kalp toksisitesinin nas\u0131l ortaya \u00e7\u0131kt\u0131\u011f\u0131na dair bir mekanizma \u00f6neren makalesi oldu. Egeli bilim insanlar\u0131n\u0131n \u00e7al\u0131\u015fmas\u0131, klozapin taraf\u0131ndan ind\u00fcklenen kardiyotoksisite alt\u0131nda yatan mekanizmay\u0131 ayd\u0131nlatma konusunda yap\u0131lan ilk \u00f6nemli \u00e7al\u0131\u015fma olarak de\u011ferlendirildi.<\/p>\n
Ger\u00e7ekle\u015ftirilen ara\u015ft\u0131rma ile ilgili bilgi veren Prof. Dr. Hilmi Orhan, \u201c\u00d6zellikle di\u011fer ila\u00e7larla yan\u0131t al\u0131namayan \u015fizofrenide kullan\u0131lan etkili bir ila\u00e7 olan klozapin, intihara yatk\u0131nl\u0131\u011f\u0131 da \u00f6nemli derecede azaltmas\u0131na kar\u015f\u0131n, hastalar\u0131n y\u00fczde birinde kan tablosunu ciddi bi\u00e7imde bozmaktad\u0131r. Bu durumda ila\u00e7 mecburen kesilmekte ve tedavi yar\u0131m kalmaktad\u0131r, aksi halde ila\u00e7tan dolay\u0131 \u00f6l\u00fcm riski vard\u0131r. Kan h\u00fccrelerinin yap\u0131m\u0131 \u00fczerindeki bu ciddi toksik etkinin (agran\u00fclositoz) kemik ili\u011finde miyeloperoksidaz enzimi taraf\u0131ndan ilac\u0131n reaktif metabolitine d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesinden kaynakland\u0131\u011f\u0131 daha \u00f6nceki \u00e7al\u0131\u015fmalarda ortaya konmu\u015ftur. Klozapin agran\u00fclositoz yan\u0131nda ayr\u0131ca hastalar\u0131n y\u00fczde 1 ila 3\u2019\u00fcnde kalp toksisitesine de neden olmakta (kardiyomiyopati ve miyokardit) ve bu hastalar\u0131n yar\u0131s\u0131 ne yaz\u0131k ki hayat\u0131n\u0131 kaybetmektedir. Ancak bu toksik etkinin neden ve nas\u0131l geli\u015fti\u011fi g\u00fcn\u00fcm\u00fcze kadar anla\u015f\u0131lamam\u0131\u015ft\u0131r\u201d dedi.<\/p>\n
\u201cH\u00fccrelerin oksijen kullan\u0131m\u0131 bask\u0131lan\u0131yor\u201d<\/b><\/p>\n
S\u00f6z konusu toksik etkiyi a\u00e7\u0131klamaya y\u00f6nelik \u00e7al\u0131\u015fmalar ger\u00e7ekle\u015ftirdiklerini belirten Prof. Dr. Orhan, \u201cAra\u015ft\u0131rmam\u0131z sonucu haz\u0131rlad\u0131\u011f\u0131m\u0131z makalemizde s\u00f6z konusu kalp toksisitesinin mekanizmas\u0131n\u0131 a\u00e7\u0131klamak \u00fczere ilac\u0131n sistemik olarak kalp dokusuna \u00f6nemli oranda da\u011f\u0131ld\u0131\u011f\u0131n\u0131, kalp h\u00fccrelerinin mitokondrilerinde reaktif metabolitine d\u00f6n\u00fc\u015ft\u00fc\u011f\u00fcn\u00fc ve lokal olu\u015fan bu metabolitin hi\u00e7 durmaks\u0131z\u0131n \u00e7al\u0131\u015fmas\u0131 ve oksijen kullanarak enerji \u00fcretmesi gereken kalp kas\u0131 h\u00fccrelerinin oksijen kullan\u0131m\u0131n\u0131 bask\u0131lad\u0131\u011f\u0131n\u0131 g\u00f6sterdik. Bu olaylar silsilesinin ise klozapine ba\u011fl\u0131 kalp toksisitesine yol a\u00e7t\u0131\u011f\u0131n\u0131 belirttik\u201d diye konu\u015ftu.<\/p>\n
\u00d6nde gelen firmalarca de\u011ferlendirilen 14 makale i\u00e7inde yer ald\u0131<\/b><\/p>\n
Prof. Dr. Hilmi Orhan ve grubunun yay\u0131nlad\u0131klar\u0131 makale; NC Eshelman School of Pharmacy, Bill & Melinda Gates Medical Research Institute, Genentech, Lipscomb University College of Pharmacy and Health Sciences, Bristol Myers Squibb, Pfizer Worldwide Research, UCB Biopharma\u202fUK, Boehringer Ingelheim Pharmaceuticals, University of Arkansas for Medical Sciences, Johns Hopkins University School of Medicine ve Biogen gibi d\u00fcnyan\u0131n ila\u00e7 ara\u015ft\u0131rmalar\u0131nda \u00f6nde gelen \u00fcniversite ve ila\u00e7 firmalar\u0131 taraf\u0131ndan yap\u0131lan de\u011ferlendirmede at\u0131fta bulunulan 14 uluslararas\u0131 makale i\u00e7inde yer ald\u0131.<\/p>\n","protected":false},"excerpt":{"rendered":"
Klozapin\u2019in kardiyotoksik etki mekanizmas\u0131n\u0131 ayd\u0131nlatmaya d\u00f6n\u00fck ilk \u00e7al\u0131\u015fma Egeli akademisyenin makalesine uluslararas\u0131 ilgi D\u00fcnyaca bilinen…<\/p>\n","protected":false},"author":2,"featured_media":10229,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,99,1,70,68],"tags":[],"class_list":["post-10228","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-egitim","category-gncl","category-kampus","category-saglik"],"featured_image_urls":{"full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi.jpg",2013,2077,false],"thumbnail":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi-150x150.jpg",150,150,true],"medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi-291x300.jpg",291,300,true],"medium_large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi-768x792.jpg",640,660,true],"large":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi-992x1024.jpg",640,661,true],"1536x1536":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi-1489x1536.jpg",1489,1536,true],"2048x2048":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi-1985x2048.jpg",1985,2048,true],"newsphere-slider-full":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi-1280x720.jpg",1280,720,true],"newsphere-featured":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi-1024x1057.jpg",1024,1057,true],"newsphere-medium":["https:\/\/www.euegeajans.com\/wp-content\/uploads\/2022\/08\/EGE-Prof-Dr-Hilmi-Orhan-ve-ekibi-720x380.jpg",720,380,true]},"author_info":{"display_name":"Editor","author_link":"https:\/\/www.euegeajans.com\/index.php\/author\/editor\/"},"category_info":"Bilim<\/a> E\u011fitim<\/a> G\u00fcncel<\/a> Kamp\u00fcs<\/a> Sa\u011fl\u0131k<\/a>","tag_info":"Sa\u011fl\u0131k","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/10228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/comments?post=10228"}],"version-history":[{"count":1,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/10228\/revisions"}],"predecessor-version":[{"id":10230,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/posts\/10228\/revisions\/10230"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media\/10229"}],"wp:attachment":[{"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/media?parent=10228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/categories?post=10228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.euegeajans.com\/index.php\/wp-json\/wp\/v2\/tags?post=10228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}